Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 diabetes

Zhang, Xiao; Liu, Jing; Sum, Chee Fang; Ying, Yeoh Lee; Tavintharan, Subramaniam; Ng, Xiao Wei; Low, Sui Pheng; Lee, Simon B.M.; Tang, Wern Ee; Lim, Su Chi

doi:10.1016/j.atherosclerosis.2015.06.019

Cited by 19 publications

(26 citation statements)

References 54 publications

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“…12 Hs-CRP was assayed on a Roche/Integra 400 Analyser (Roche Diagnostics, Rotkreuz, Switzerland) by a particle-enhanced immunoturbidimetric method. Carotid-femoral PWV and AI were measured as described previously.…”

Section: Clinical Biochemical and Cas Measurementmentioning

confidence: 99%

Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes

Zhang

Liu

Sum

et al. 2016

Diabetes and Vascular Disease Research

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Section: Clinical Biochemical and Cas Measurementmentioning

confidence: 99%

Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes

Zhang

Liu

Sum

et al. 2016

Diabetes and Vascular Disease Research

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“…Thus, the final cohort examined in this study comprised 1014 individuals. Information on participants' demographic characteristics, medical history, smoking status, and medication use were collected using a data collection form …”

Section: Methodsmentioning

confidence: 99%

“…Information on participants' demographic characteristics, medical history, smoking status, and medication use were collected using a data collection form. [9][10][11] This study was performed in accordance with the Declaration of Helsinki (2013 version) and was approved by the National Healthcare Group domain specific ethics review board. Written informed consent was obtained from all participants.…”

Section: Participantsmentioning

confidence: 99%

Gain in adiposity over 3 years is associated with progressive renal decline in multi‐ethnic South‐east Asians with type 2 diabetes

Moh

Sum

Tavintharan

et al. 2018

Journal of Diabetes

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Background This study evaluated the association between gain in adiposity and renal decline in a large prospective multiethnic South‐east Asian cohort with type 2 diabetes mellitus (T2DM). Methods Three years after the baseline visit, 2057 T2DM subjects were recalled for reassessment. The final cohort comprised 1014 subjects and was categorized into tertiles based on changes in body weight (ΔWt), body mass index (ΔBMI), visceral fat area (ΔVFA), and BMI‐adjusted VFA (ΔVFABMI). Outcomes included annual and rapid (≥3 mL/min per 1.73 m2 per year) decline in estimated glomerular filtration rate (eGFR) and progression of albuminuria. Results Participants (mean [±SD] age 57 ± 11 years, 48.8% women, BMI 27.7 ± 5.4 kg/m2) exhibited a median annual decline in eGFR of 1.0 mL/min per 1.73 m2. Compared with the lower tertiles, Tertile 3 of ΔWt, ΔBMI, ΔVFA, and ΔVFABMI had the highest anthropometric increase, albeit of modest magnitude, and this was accompanied by the worst renal outcomes (all P < 0.05). The relationship between annual eGFR decline and Tertile 3 of ΔWt, ΔBMI, and ΔVFABMI persisted after multivariate adjustment in men but not in women. In addition, Tertile 3 of ΔWt, ΔBMI, ΔVFA, and ΔVFABMI predicted rapid eGFR decline. Anthropometric gains were also associated with progression of albuminuria. Conclusions Modest longitudinal gain in adiposity was associated with progressive renal decline in T2DM patients, suggesting that increased adiposity over time adversely affects renal outcomes. Therefore, a carefully designed weight‐neutral or ‐loss antidiabetic treatment regimen is important when managing T2DM in the clinic.

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“…[7] In large population-based studies, arterial pulse waveforms have also demonstrated variation with ethnicity. [8][9][10] A Singapore study showed that Malay and Indian diabetic patients have higher central arterial stiffness, in the form of carotidfemoral pulse wave velocity and AIx, compared to Chinese patients. [8] These differences remained even after adjusting for glycated hemoglobin, proteinuria, and demographics.…”

Section: Variables That Affect Central Arterial Pulse Waveformsmentioning

confidence: 99%

Central Aortic Blood Pressure as an Indica tor of Prognosis: An Asian Perspective

Ngoh¹,

Wong²,

Ling³

2018

johtn

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Brachial cuff sphygmomanometer remains the major method by which blood pressure (BP) is assessed clinically. However, this is a poor surrogate for central aortic BP. There is increasing evidence that central aortic BP can act as a marker of cardiovascular (CV) and peripheral vascular disease burden and that central pressures may be able to predict CV events and mortality. This, in turn, could have implications for the development and application of future pharmacological therapies. This review article examines the evidence surrounding the above and its controversies. It concludes that while central BP is an exciting new frontier, more research is required for central BP to become commonplace in clinical medicine.

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Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 diabetes

Cited by 19 publications

References 54 publications

Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes

Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes

Gain in adiposity over 3 years is associated with progressive renal decline in multi‐ethnic South‐east Asians with type 2 diabetes

Central Aortic Blood Pressure as an Indica tor of Prognosis: An Asian Perspective

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