High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders

Hesapçıoğlu, Selma Tural; Kaşak, Meryem; Kurt, Ayşegül Neşe Çıtak; Ceylan, Mehmet Fatih

doi:10.1080/20473869.2017.1371369

Cited by 22 publications

(28 citation statements)

References 50 publications

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“…Along with our result these finding may suggest that degree of immune activation varies with severity of ASD. 23 We think that the distinct immune profile found in this study is related to the majority of the children with atypical autism. Heterogeneity is a hallmark of ASD.…”

Section: Discussionmentioning

confidence: 97%

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Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Kutlu¹,

Binici²

2018

Anadolu Psikiyatri Derg

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Section: Discussionmentioning

confidence: 97%

“…In literature there is only one study focused on NLR in ASD. 23 In this study we aimed to investigate the immune dysregulation in the etiology of ASD by assessing NLR and PLR in children with ASD compared to healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Kutlu¹,

Binici²

2018

Anadolu Psikiyatri Derg

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“…To our knowledge, only two previous studies have explored NLR in ASD. They reported no association with ASD but without considering the heterogeneity of individuals regarding MIA (15,16). The authors however showed a trend for a signi cant correlation between NLR and autistic symptom severity.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, there is a growing interest in NLR in psychiatric disorders suspected to be related to an immune deregulation such as schizophrenia, bipolar disorders or depression (14). To our knowledge, only two studies examined NLR in ASD, but with inconclusive results (15,16). None of these reports however assessed the impact of MIA in the NLR variability.…”

Section: Introductionmentioning

confidence: 99%

Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation Running: Maternal immune activation in ASD

Ellul

Maruani

Peyre

et al. 2022

Preprint

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Background: Maternal immune activation (MIA) during the two first trimesters of pregnancy could be a risk factor for autism spectrum disorders (ASD) in offspring. In mice, MIA has a long-term impact on offspring’s immune equilibrium resulting in a pro-inflammatory phenotype. Methods: We therefore hypothesized that children with ASD and a history of MIA could display a similar phenotype such as a higher neutrophil to lymphocyte ratio (NLR). In this study, we used a retrospective sample of 231 dyads involving children with ASD and their mothers.Results: Among ASD patients, 12% had a history of MIA. We observed an abnormal NLR (over 3) in 7.4% of children with ASD MIA+ compared to 1.9% for MIA. The multivariate analysis revealed a significant association between NLR in children with ASD and maternal history of MIA (F=2.27, p=0.03). Limitations: Data collection on events during pregnancy was retrospective and our sample size was small for the MIA+ group. These limitations are offset by the use of strict criteria on the definition of MIA in pregnancy.Results: Our study reinforced preliminary evidence suggesting an impact of MIA on the risk of autism. Further studies could contribute to the development of biomarkers in MIA+ ASD and enable the development of targeted immunomodulatory therapies.

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“…In recent years, there is a growing interest in NLR in psychiatric disorders suspected to be related to an immune deregulation such as schizophrenia, bipolar disorders or depression [14]. To our knowledge, only two studies examined NLR in ASD, but with inconclusive results [15,16]. None of these reports however assessed the impact of MIA in the NLR variability.…”

Section: Introductionmentioning

confidence: 99%

Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation

Ellul

Maruani

Peyre

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Maternal immune activation (MIA), related to autoimmune/inflammatory diseases or acute infections, during the two first trimesters of pregnancy is a risk factor for autism spectrum disorders (ASD) in offspring. In mice, MIA has a long-term impact on offspring’s immune equilibrium resulting in a pro-inflammatory phenotype. Methods: We therefore hypothesized that children with ASD and a history of MIA could display a similar phenotype such as a higher neutrophil to lymphocyte ratio (NLR). In this study, we used a retrospective sample of 231 dyads involving children with ASD and their mothers. Results: Among ASD patients, 12% had a history of MIA. The multivariate analysis revealed a significant association between NLR in children with ASD and maternal history of MIA (F=2.27, p=0.03). Using a categorical approach, we observed an abnormal NLR (over 3) in 7.4% of children with ASD MIA+ compared to 1.9% for MIA-. Conclusion: Our study reinforced preliminary evidence suggesting an impact of MIA on the risk of ASD. Further studies could contribute to the development of biomarkers in MIA+ ASD and enable the development of targeted immunomodulatory therapies.

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High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders

Cited by 22 publications

References 50 publications

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation Running: Maternal immune activation in ASD

Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation

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