High mannose N-glycan binding lectin from Remusatia vivipara (RVL) limits cell growth, motility and invasiveness of human breast cancer cells

Sindhura, B R; Hegde, Prajna; Chachadi, Vishwanath B.; Inamdar, Shashikala R.; Swamy, Bale M.

doi:10.1016/j.biopha.2017.06.081

Cited by 25 publications

(13 citation statements)

References 53 publications

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“…However, 33% of the unigenes remain unannotated, probably because more unigenes were generated with the sequencing depth of 10 G and because the publicly available plant transcriptome and genome data are insufficient. These predicted CDSs, accounting for 60.0% of the total unigenes, provide information for studying crucial genes, including genes encoding lectins 28 and ribosome-inactivating proteins 29 , which are potential anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

De novo assembly and analysis of the Artemisia argyi transcriptome and identification of genes involved in terpenoid biosynthesis

Liu

Zhu

et al. 2018

Sci Rep

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Artemisia argyi Lev. et Vant. (A. argyi) is widely utilized for moxibustion in Chinese medicine, and the mechanism underlying terpenoid biosynthesis in its leaves is suggested to play an important role in its medicinal use. However, the A. argyi transcriptome has not been sequenced. Herein, we performed RNA sequencing for A. argyi leaf, root and stem tissues to identify as many as possible of the transcribed genes. In total, 99,807 unigenes were assembled by analysing the expression profiles generated from the three tissue types, and 67,446 of those unigenes were annotated in public databases. We further performed differential gene expression analysis to compare leaf tissue with the other two tissue types and identified numerous genes that were specifically expressed or up-regulated in leaf tissue. Specifically, we identified multiple genes encoding significant enzymes or transcription factors related to terpenoid synthesis. This study serves as a valuable resource for transcriptome information, as many transcribed genes related to terpenoid biosynthesis were identified in the A. argyi transcriptome, providing a functional genomic basis for additional studies on molecular mechanisms underlying the medicinal use of A. argyi.

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Section: Discussionmentioning

confidence: 99%

De novo assembly and analysis of the Artemisia argyi transcriptome and identification of genes involved in terpenoid biosynthesis

Liu

Zhu

et al. 2018

Sci Rep

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“…Shivamadu et al (2017) observou em seus estudos que a lectina isolada de frutos de Praecitrullus fistulosus também reduziu a angiogênese in vivo quando aplicada em camundongos com ascite de Ehrlich (EAC), através da inibição do fator de crescimento endotelial vascular (VEGF), que é um fator essencial para o desenvolvimento de novos vasos sanguíneos, e consequentemente para o desenvolviemento e crescimento de tumores. A lectina isolada do tuérculo da Remusatia vivipara, foi capaz de inibir a angiogênese e vasulogênese da Membrana Corioalantóide (MCA) de ovos de galinha, como efeito sinérgico também promoveu a diminuião da densidade dos novos vasos formados (SINDHURA at al., 2017).…”

Section: Resultsunclassified

“…Na MSV também se formam células tronco muitipotentes e o próprio hemangioblasto, precursor comum para estas células, que se formam durante a vasculogênese. Os hemangioblastos migram em direção ao espaço entre o epiblasto e o hipolasto, chegando ao mesoderma lateral do saco vitelínico (SV), onde irão se agrupar formando ilhotas sanguíneas (KENNEDY et al, 2007;WENG & SHENG, 2014;LI et al, 2014). A formação das ilhotas sanguíneas e posteriormente dos plexos vasculares primários, se dá a partir dos hemangioblastos, em um processo chamado de vasculogênese, que é a formação de novos vasos sanguíneos (CZIROK & LITTLE, 2012;LIU et al, 2014).…”

Section: Introductionunclassified

“…Apresentando funções imunológicas, hematopoiética, secretora, nutricional, e metabólica. Diferente dos mamíferos a membrana do saco vitelínico (MSV) de aves permanece durante toda sua embriológica (SPEAKE et al, 1998;HYTTEL, et al, 2010). A geometria fractal ou geometria da natureza é utilizada corriqueiramente para descrição de formas irregulares enconradas na natureza, como a rede vascular sanguínea, por exemplo (MANDELBROT, 1991).…”

Section: Introductionunclassified

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AVALIAÇÃO DOS FEITOS DA LECTINA DE FOLHAS DE Schinus terebinthifollia Raddi SORE A FORMAÇÃO DE NOVOS VASOS SANGUÍNEOS

Santos¹,

Araújo²,

França³

et al. 2019

Blucher Biophysics Proceedings

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“…Limits growth, motility and invasiveness of human breast cancer cells Sindhura et al, 2017 worked on the binding of lectin to a speci ic site, apoptosis, growth inhibition and induction of reactive oxygen species for cell death by the use of different cell lines like MDA-MB-468, MCF-7 and MCF-10A. The results and indings suggested that Remusatia Vivipara Lectin (RVL) showed very high cell surface binding to cell lines, different dose of RVl on different time intervals showed a decrease in cell viability, after treatment with RVL from 0-24 hours microscopic studies showed cell changes, RVL also reported for inducing the apoptosis in both MDA-MB-468 and MCF-7 through oxidative stress or DNA damage.…”

Section: Depressant Activitymentioning

confidence: 99%

A Rare Medicinal Herb Remusatia Vivipara

Bhurat¹,

Sharma²,

Budhrani³

et al. 2021

ijrps

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In this current era, the demand for herbal medicines and products is increasing globally, and herbal medicines are being used traditionally as well as for the modern systems for treatment of various diseases and ailments. There are so many plants that are under research for their potential therapeutic and pharmaceutical applications, and Remusatia Vivipara is one of that rare plants belonging to the family Araceae. There are 105 Genera; more than 3300 species persist locally in tropical and sub-tropical areas and world widely. Remusatia Vivipara is commonly known as “Hitchhiker Elephant ear”. Tribal people also named it as Lalkand. The root juice of Remusatia Vivipara used on the wound to dispel any germ and worms. Remusatia Vivipara has many folkloric applications like for Inflammation and arthritis treatment, analgesic, for disinfecting the Genitourinary tract, and treatment of reddish boils. Upon hydrolysis arabinose, galactose, glucose, mannose, xylose, and various uronic acids are the most commonly observed components. This review is an attempt to compile all the aspects and details of plant Remusatia vivipara.

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High mannose N-glycan binding lectin from Remusatia vivipara (RVL) limits cell growth, motility and invasiveness of human breast cancer cells

Cited by 25 publications

References 53 publications

De novo assembly and analysis of the Artemisia argyi transcriptome and identification of genes involved in terpenoid biosynthesis

De novo assembly and analysis of the Artemisia argyi transcriptome and identification of genes involved in terpenoid biosynthesis

AVALIAÇÃO DOS FEITOS DA LECTINA DE FOLHAS DE Schinus terebinthifollia Raddi SORE A FORMAÇÃO DE NOVOS VASOS SANGUÍNEOS

A Rare Medicinal Herb Remusatia Vivipara

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