High magnification and fluorescence advanced videodermoscopy for hypomelanotic melanoma

Cinotti, Élisa; Cortonesi, Giulio; Rubegni, Pietro

doi:10.1111/srt.12855

Cited by 8 publications

(18 citation statements)

References 10 publications

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“…Morphology and distribution of vessels represent the main features to assess in such lesions, together with some additional clinical criteria: EFG (Elevated, Firm, rapidly Growing) criteria 4,32,37 . Regarding the importance of vascular structures in the diagnosis of “pink tumors”, high magnification and fluorescence advanced digital dermoscopy represent valid options together with classical dermoscopy in defining the vascular pattern of such lesions 33,34 …”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study

et al. 2020

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Background Amelanotic and hypomelanotic melanoma (AHM) has a higher risk of delayed diagnosis and a significant lower 5-year melanoma-specific survival compared to pigmented melanoma. Our aim was the evaluation of the clinicopathological/dermoscopic features of amelanotic melanoma (AM) and hypomelanotic melanoma (HM). Methods All participants had a personal history of AHM. We defined HM as showing clinical/dermoscopic pigmentation in < 25% of the lesion's surface and histopathological focal pigmentation, while AM as melanomas with clinical/dermoscopic and histopathological absence of pigmentation. Results The most common phenotypic traits among the 145 AHM patients were as follows: phototype II, blue-grey eyes, and dark brown hair. Red hair was present in 23.8% AHM cases (AM = 22.60%; HM = 25.80%). The most affected area was the back (29.5%). A total of 67.1% were classified as AM and 32.9% as HM. The most represented hair colors in AM and HM were, respectively, blonde and dark brown hair. Median Breslow thickness was 1.7 mm, superficial spreading melanoma (SSM) and nodular melanoma (NM) were the most represented histotypes, and mitotic rate > 1 9 mm 2 was reported in 73.3% cases, and regression was significantly more present in HM. Dermoscopy showed high prevalence of white structureless zones (63.4%), linear looped vessels (58.8%), linear irregular vessels (50.0%), and arborizing vessels (47.2%). Multivariate logistic regression confirmed the association between the presence of pigmentation and the following: histological regression, dermoscopic globules, and arborizing vessels. Conclusions Predominance of red hair in AHM patients was not confirmed. AHM affects mostly intermittent sun-exposed body areas. The deeper median Breslow thickness (versus pigmented melanoma), the association of AM with the nodular histotype, and the high mitotic rate highlight the AHM's aggressiveness. HM's higher levels of regression can be explained by the presence of pigmentation, driving the underlying immune response. AHM showed a polymorphous vascular pattern and significant presence of arborizing vessels (especially HM).

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Section: Discussionmentioning

confidence: 99%

Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study

et al. 2020

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“…The fluorescence-advanced videodermatoscopy (FAV) is an emerging non-invasive imaging method to assess melanocytic skin lesions in vivo, in addition to clinical and dermatoscopic analysis. 2,3 FAV integrates videodermatoscopy with the fluorescence of a hand-held probe. This latter consists of a monochromatic light source with a wavelength (λ) of 405 nm (±5 nm) and a fixed angle of incidence.…”

Section: Videodermoscopic Folliculotropism As a Sign Of Lentigo Maligna In The Fluorescence-advanced Videodermatoscopy (Fav)mentioning

confidence: 99%

Videodermoscopic folliculotropism as a sign of lentigo maligna in the fluorescence‐advanced videodermatoscopy (FAV)

Scarfì

Trane

Maio

et al. 2021

Skin Research and Technology

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“…Notably, melanin and hemoglobin are dark in FAV but bright in RCM. 25 One study proposed FAV as a promising technique for the in vivo evaluation of vitiligo. FAV displays a complete disappearance of epidermal pigmentation and a lack of melanocytes at the stratum basale in well-established vitiliginous lesions, and the erythrocytes within…”

Section: Fluore Scen Ce-advan Ced Videodermatoscopymentioning

confidence: 99%

Recent developments in dermoscopy for dermatology

Chen

et al. 2020

J of Cosmetic Dermatology

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Background: Dermoscopy is considered to be a bridge between clinical observation and histopathological examination, allowing the in vivo examination of skin microstructures that are not visible to the naked eye, from the epidermis to the superficial dermis. Dermoscopy has undergone rapid development, witnessing the history from natural light to polarized light, from handheld dermoscopy to videodermoscopy, and from classic dermoscopy to digital dermoscopy. Its application extends from the initial differential diagnosis of pigmented skin diseases (melanocytic and nonmelanocytic) to general dermatology, including appendage (nail and hair) abnormalities and diseases related to infection and inflammation. Aims:We aimed to provide the latest developments in dermoscopy from the perspective of handheld dermoscopy, videodermoscopy, fluorescence-advanced videodermatoscopy, polarized transilluminating dermoscopy, and digital dermoscopy. Methods:In this review, we searched the PubMed, Embase, Web of Science, and Cochrane Library databases for reviews, case reports, and observational studies on dermoscopy. Results:We provided an updated review of dermoscopy based on published literature. Conclusion:Dermoscopy is an indispensable diagnostic tool in dermatology, and it is expected to be further developed in the future.

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High magnification and fluorescence advanced videodermoscopy for hypomelanotic melanoma

Cited by 8 publications

References 10 publications

Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study

Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study

Videodermoscopic folliculotropism as a sign of lentigo maligna in the fluorescence‐advanced videodermatoscopy (FAV)

Recent developments in dermoscopy for dermatology

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