High Long-Term Cortisol Levels, Measured in Scalp Hair, Are Associated With a History of Cardiovascular Disease

Manenschijn, Laura; Schaap, Laura A.; Schoor, Natasja M. van; Pas, Suzan van der; Peeters, Geeske; Lips, Paul; Koper, Jan W.; Rossum, Elisabeth F.C. van

doi:10.1210/jc.2012-3663

Cited by 178 publications

(172 citation statements)

References 37 publications

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“…For example, HCC has been validated in conditions known to be associated with altered corstiol secretion, such as Cushing Syndrome (Manenschijn et al, 2012;Thomson et al, 2010) and pregnancy (Kirschbaum et al, 2009;Steptoe et al, 2003); HCC appears higher in chronically stressed dementia caregivers who report depressive symptoms , and has been linked with cardiovascular disease (Manenschijn et al, 2013). In the general population, in the absence of such manifest (or developing) conditions, HCC could still provide a useful biomarker of stress, but its association with perceived stress is perhaps not a useful means of validation.…”

Section: Discussionmentioning

confidence: 99%

“…First, our sample size compares favourably with many others in the field, but challenges in recruitment prevented a larger sample that would have provided greater statistical power and, perhaps, greater range in stress levels. Sample size has often been a limited in HCC studies, but some larger studies have been published (Dettenborn et al, 2012a;Manenschijn et al, 2013;Wells et al, 2014), and more are needed. Second, PSS data were collected at baseline as a marker of general stress, with EMA providing the more novel measure of perceived stress for the time period corresponding with the 12-week HCC period.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence is accumulating for the potential application of HCC in clinical and epidemiological studies (Wester and van Rossum, 2015;Wosu et al, 2013) and various relationships have been demonstrated between HCC and, for example, Cushing's Syndrome (Manenschijn et al, 2012), cardiovascular disease (Manenschijn et al, 2013), depression and mood disorders (Dettenborn et al, 2012b), and anxiety (Steudte et al, 2011). However, the association between HCC and subjectively measured stress remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Hair cortisol and self-reported stress in healthy, working adults

Gidlow

Randall²,

Gillman

et al. 2016

Psychoneuroendocrinology

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Chronic stress can be important in the pathology of chronic disease. Hair cortisol concentrations (HCC) are proposed to reflect long term cortisol secretion from exposure to stress. To date, inconsistencies in the relationship between HCC and self-reported stress have been attributed to variation and limitations of perceived stress measurement. We report data from employees of two large public sector worksites (n=132). Socio-demographic, health, lifestyle, Perceived Stress Scale (PSS), and work-related Effort Reward Imbalance (ERI) were collected at baseline. Participants were asked to respond to mobile text messages every two days, asking them to report current stress levels (Ecological Momentary Assessment, EMA), and mean stress was determined overall, during work hours, and out of work hours. At 12 weeks, the Appraisal of Stressful Life Events Scale (ALES) was completed and 3cm scalp hair samples were taken, from which HCC was determined (to reflect cortisol secretion over the past 12 weeks). Mean response rate to EMA was 81.9±14.9%. Associations between HCC and the various self-reported stress measures (adjusted for use of hair dye) were weak (all <.3). We observed significant associations with HCC for EMA measured stress responses received out of work hours (ρ=.196, p=.013) and ALES Loss subscale (ρ=.241, p=.003), and two individual items from ERI (relating to future work situation). In regression analysis adjusting for other possible confounders, only the HCC-ALES Loss association remained significant (p=.011). Overall, our study confirms that EMA provides a useful measurement tool that can gather perceived stress measures in real-time. But, there was no relationship between self-reported stress collected in this way, and HCC. The modest association between HCC and stress appraisal does however, provide some evidence for the role of cognitive processes in chronic stress.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hair cortisol and self-reported stress in healthy, working adults

Gidlow

Randall²,

Gillman

et al. 2016

Psychoneuroendocrinology

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“…Se encontraron diferencias significativas en los pares (b, c); (d, e); (f, g) y (h, i). Sauve et al 2007;(b, c) Thomson et al 2009;(d, e) Van Uum et al 2008;(f, g) Pereg et al 2011;(h, i) Manenschijn et al 2011;(j) Manenschijn et al 2013;(k) Webb et al 2009;(l, m) …”

Section: Discussionunclassified

“…El nivel de cortisol se determinó mediante un método ELISA utilizado en investigaciones anteriores (Manenschijn et al 2013;Pereg et al 2011;Sauvé et al 2007;Thomson et al 2010;Van Uum et al 2008). El cabello se cortó finamente (trozos < 2 mm de longitud) y 10 mg de cada muestra fueron pulverizadas usando 20 esferas de acero de 1,5 mm de diámetro en viales de acero de 1,8 ml durante 10 minutos en un homogeneizador Mini-Beadbeater-96 (Biospec Inc., Bartlesville, OK, USA).…”

Section: Determinación Y Análisis De Niveles De Cortisolunclassified

Niveles De Cortisol en Cabellos De Poblaciones Prehispánicas De San Pedro De Atacama, Norte De Chile

López-Barrales¹,

Hübbe

Aspillaga

et al. 2015

Chungará (Arica)

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La presente investigación explora el grado de estrés sistémico al que estaban sometidas las poblaciones de San Pedro de Atacama durante los períodos Medio e Intermedio Tardío mediante el análisis de cortisol en el cabello de restos humanos de estos períodos. Los niveles similares de cortisol encontrados en los individuos de San Pedro de Atacama y en individuos actuales sugieren que, si bien las condiciones ambientales y sociales de las poblaciones prehispánicas fueron muy distintas a las actuales, la población prehispánica en San Pedro de Atacama no estaba sometida a niveles de estrés sistémico mayores que la actual, posiblemente debido a la larga historia de ocupación en la región que permitió que dichas poblaciones se adaptaran a sus condiciones particulares. Los niveles de cortisol de los individuos analizados del período Medio mostraron una tendencia a ser menores que los del Intermedio Tardío, congruente con las diferencias en la calidad de vida sugeridos por marcadores osteológicos y con los cambios culturales y ambientales asociados a ambos períodos. Aunque diversos factores pueden afectar los niveles de cortisol encontrados en muestras arqueológicas, este marcador muestra el potencial para complementar los resultados obtenidos sobre las poblaciones de San Pedro de Atacama utilizando otros enfoques.Palabras claves: bioarqueología, estrés sistémico, cortisol, cabello. Systemic stress in prehispanic populations of San Pedro de Atacama (SPA) during the Middle and Late Intermediate periods was explored through cortisol analysis of hair samples of mummies from these periods. The cortisol levels in the

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The potential of using hair cortisol to measure chronic stress in occupational healthcare; a scoping review

Schaafsma

Hulsegge

Jong

et al. 2021

Journal of Occupational Health

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Objectives: Workplace-based selective prevention of mental health problems currently relies on subjective evaluation of stress complaints. Hair cortisol captures chronic stress responses and could be a promising biomarker for the early identification of mental health problems. The objective was to provide an overview of the state-of-the-art knowledge on the practical value of hair cortisol in the occupational setting. Methods: We performed a scoping review of cross-sectional and longitudinal studies in PubMed, Embase, and PsycINFO up to November 2019 assessing the relations of hair cortisol with work-related stressors, perceived stress, and mental health outcomes in healthy workers. Results: We found five longitudinal studies, of which two observed an increase in work-related stressors to be associated with higher hair cortisol, one found a relation with lower hair cortisol and one did not find a relationship. Findings of crosssectional studies were also mixed. The one available longitudinal study regarding mental health showed that hair cortisol was not related to depressive symptoms. Conclusions: Hair cortisol measurement within occupational health research is still in its early stage and more longitudinal studies are urgently needed to clarify its relationship with work-related stressors and perceived stress before hair cortisol can be used to identify workers at risk for mental health problems.

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High Long-Term Cortisol Levels, Measured in Scalp Hair, Are Associated With a History of Cardiovascular Disease

Cited by 178 publications

References 37 publications

Hair cortisol and self-reported stress in healthy, working adults

Hair cortisol and self-reported stress in healthy, working adults

Niveles De Cortisol en Cabellos De Poblaciones Prehispánicas De San Pedro De Atacama, Norte De Chile

The potential of using hair cortisol to measure chronic stress in occupational healthcare; a scoping review

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