High levels of Trypanosoma cruzi DNA determined by qPCR and infectiousness to Triatoma infestans support dogs and cats are major sources of parasites for domestic transmission

Enriquez, Gustavo Fabián; Búa, Jacqueline; Orozco, Marcela; Wirth, Sonia; Schijman, Alejandro G.; Gürtler, Ricardo E.; Cardinal, Marta Victoria

doi:10.1016/j.meegid.2014.04.002

Cited by 59 publications

(72 citation statements)

References 44 publications

(82 reference statements)

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“…The prevalence of xenodiagnosis-positive dogs and their infectiousness either were ageindependent or declined marginally or significantly with age ( Figure 1B) (Enriquez et al, 2014;Gürtler et al, 2007a;Gürtler et al, 1998bGürtler et al, , 1996aGürtler et al, , 1992aGürtler et al, , 1986bLauricella et al, 1989). The potential contribution of pups to bug infection (P a ) was approximately 50% greater than that of the older age groups combined (Gürtler et al, 1996a).…”

Section: Host Infectiousnessmentioning

confidence: 97%

“…Xenodiagnosis-positive dogs were also successfully identified by quantitative real-time PCR (qPCR), and the concentration of T. cruzi DNA correlated closely with dog infectiousness (Enriquez et al, 2014). In systematic surveys of well-defined populations, the prevalence of xenodiagnosis-positive individuals among domestic dogs (28.6%) and cats (19.7%) exceeded that in humans (5.7%) in southeast Brazil (Freitas, 1950), and a similar ranking was often recorded in areas infested by R. prolixus, T. dimidiata and T. infestans (Gürtler et al, 1996a;Pifano, 1973;Zeledon et al, 1975).…”

Section: Host Infectiousnessmentioning

confidence: 99%

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Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

2015

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Section: Host Infectiousnessmentioning

confidence: 97%

Section: Host Infectiousnessmentioning

confidence: 99%

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

2015

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“…(1) (2) (3) (4) . These animals are of particular interest with regard to the transmission cycle of Leishmania chagasi and Trypanosoma cruzi, because they are considered reservoirs for both agents and enhancers of transmission in the peridomicile, and consequently a risk factor for the human population (3) (4) .…”

Section: Domestic Dogs Are Naturally Infected With Different Species mentioning

confidence: 99%

“…These animals are of particular interest with regard to the transmission cycle of Leishmania chagasi and Trypanosoma cruzi, because they are considered reservoirs for both agents and enhancers of transmission in the peridomicile, and consequently a risk factor for the human population (3) (4) . Trypanosoma caninum is the most recently described species of the Trypanosoma genus affecting dogs (5) , with 53 cases confirmed in different regions of Brazil (6) prior to this present study.…”

Section: Domestic Dogs Are Naturally Infected With Different Species mentioning

confidence: 99%

Report of new cases of Trypanosoma caninum in Brazil

Oliveira

Barros

Perez

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction: Trypanosoma caninum is a protozoan species recently described in dogs, whose occurrence has been reported in areas of overlap with visceral leishmaniasis. Methods: Trypanosoma sp. were isolated from nine dogs and characterized by molecular methods. Results: PCR and sequencing confi rmed the presence of T. caninum in all dogs, revealing two new areas of transmission: Barra Mansa and São João do Piauí. Conclusions: The nine new cases described, when added to those already published, account for 62 cases of natural infection by T. caninum and show the geographical spread of this species to new areas, where other trypanosomatids circulate.

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“…La prevalencia de la enfermedad en estos países no endémicos es proporcional al número de inmigrantes procedentes de áreas endémicas y la prevalencia de portadores está determinada, a su vez, por la prevalencia en el país de origen (10). Estados Unidos no debe clasificarse como un país no endémico de la enfermedad, ya que se han reportado 11 especies de triatominos dentro de su territorio y reservorios selváticos como mapaches, zarigüeyas (tlacuaches) y animales domésticos, además de que existen casos autóctonos de la enfermedad reportados en el país (11,12) y casi 300 mil habitantes infectados con T. cruzi (13).…”

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Anti-Trypanosoma cruzi antibodies in Latin American migrants in transit through the México- USA border

2018

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Introducción. En los últimos años, la tripanosomiasis americana se ha convertido en un problema de salud pública emergente en países receptores de poblaciones migrantes, como México, Estados Unidos, Canadá y los países europeos.Objetivo. Analizar la prevalencia de anticuerpos anti-Trypanosoma cruzi mediante técnicas serológicas, en los migrantes latinos en su paso hacia Estados Unidos y Canadá.Materiales y métodos. Se hicieron análisis serológicos mediante ELISA y la prueba de hemaglutinación indirecta (HAI) para detectar anticuerpos anti-T. cruzi, y encuestas socioeconómicas para determinar los factores asociados a los casos seropositivos que favorecieron la transmisión en el país de origen de los migrantes.Resultados. La seroprevalencia total en la población estudiada fue del 20 % (24/120). La prevalencia más alta se encontró en migrantes de Guatemala, con 37,5 % (6/16), seguidos de los de Honduras (22,6 %; 12/53), El Salvador (16 %; 4/25) y México (8,7 %; 3/23). De los 120 migrantes encuestados, 105 (87,5 %) reconocieron el vector y 62 (59 %) afirmaron haber sido picados por este. La asociación de la infección con los materiales de construcción de las paredes de las viviendas, así como con la presencia de mascotas (perros) en los hogares, fue muy significativa (p≤0,01). La asociación con el material de construcción del patio, los servicios básicos precarios, así como la cría de animales dentro de corrales en la periferia de los hogares, también fue significativa (p≤0,05).Conclusión. Los países no endémicos que reciben migrantes de zonas endémicas deben mejorar o desarrollar políticas de salud para prevenir la transmisión del parásito por transfusión o por vía congénita.

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High levels of Trypanosoma cruzi DNA determined by qPCR and infectiousness to Triatoma infestans support dogs and cats are major sources of parasites for domestic transmission

Cited by 59 publications

References 44 publications

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

Report of new cases of Trypanosoma caninum in Brazil

Anti-Trypanosoma cruzi antibodies in Latin American migrants in transit through the México- USA border

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