High levels of proinflammatory cytokines IL-6, IL-8, TNF-Α, IL-23, and IFN- in Tunisian patients with type 1 autoimmune hepatitis

Chaouali, Maroua; Azaiez, Mouna Ben; Tezeghdenti, A.; Yacoubi-Oueslati, Besma; Ghazouani, Ezzedine; Kochkar, Radhia

doi:10.1684/ecn.2020.0450

Cited by 14 publications

(5 citation statements)

References 33 publications

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“…The balance and coordination of these Th cell subsets are crucial for a well-regulated immune system, and their dysregulation can lead to various immunological disorders and diseases [ 68 ]. The majority of VS patients exhibited AIH-like signatures, characterized by a more prominent inflammatory cytokine signature with the highest levels of IFN-γ, TNF-α, IL-9, and IL-17, aligning with AIH data from others [ 70 , 71 ]. Additionally, our results identified IL-4 as a significant predictor of biochemical response to treatment in multivariate analysis.…”

Section: Discussionsupporting

confidence: 77%

Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

Yang,

Zhou,

Shen

et al. 2024

J Transl Med

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Background Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC, leading to poorer prognoses than those with PBC or AIH alone. The biomarkers associated with drug response and potential molecular mechanisms in this syndrome have not been fully elucidated. Methods Whole-transcriptome sequencing was employed to discern differentially expressed (DE) RNAs within good responders (GR) and poor responders (PR) among patients with PBC/AIH VS. Subsequent gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted for the identified DE RNAs. Plasma metabolomics was employed to delineate the metabolic profiles distinguishing PR and GR groups. The quantification of immune cell profiles and associated cytokines was achieved through flow cytometry and immunoassay technology. Uni- and multivariable logistic regression analyses were conducted to construct a predictive model for insufficient biochemical response. The performance of the model was assessed by computing the area under the receiver operating characteristic (AUC) curve, sensitivity, and specificity. Findings The analysis identified 224 differentially expressed (DE) mRNAs, 189 DE long non-coding RNAs, 39 DE circular RNAs, and 63 DE microRNAs. Functional pathway analysis revealed enrichment in lipid metabolic pathways and immune response. Metabolomics disclosed dysregulated lipid metabolism and identified PC (18:2/18:2) and PC (16:0/20:3) as predictors. CD4+ T helper (Th) cells, including Th2 cells and regulatory T cells (Tregs), were upregulated in the GR group. Pro-inflammatory cytokines (IFN-γ, TNF-α, IL-9, and IL-17) were downregulated in the GR group, while anti-inflammatory cytokines (IL-10, IL-4, IL-5, and IL-22) were elevated. Regulatory networks were constructed, identifying CACNA1H and ACAA1 as target genes. A predictive model based on these indicators demonstrated an AUC of 0.986 in the primary cohort and an AUC of 0.940 in the validation cohort for predicting complete biochemical response. Conclusion A combined model integrating genomic, metabolic, and cytokinomic features demonstrated high accuracy in predicting insufficient biochemical response in patients with PBC/AIH VS. Early recognition of individuals at elevated risk for insufficient response allows for the prompt initiation of additional treatments.

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Section: Discussionsupporting

confidence: 77%

Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

Yang,

Zhou,

Shen

et al. 2024

J Transl Med

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“…Estrogen modulates the production of cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), TNF-alpha and IFN-γ, among others [262][263][264][265][266][267]. These cytokines are important in regulating immune responses and play a role in inflammatory and autoimmune diseases [268][269][270][271]. Estrogen stimulates cytokine release by binding to the Estrogen receptors (ERs), ER-alpha (ERα) and ER-beta (ERβ), which are expressed on the surface of immune cells [272].…”

Section: Influence Of Sex On Hiv Transmission and Immune Responsesmentioning

confidence: 99%

HIV–Host Cell Interactions

Masenga,

Mweene,

Luwaya

et al. 2023

Cells

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The development of antiretroviral drugs (ARVs) was a great milestone in the management of HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells and prolonging life. However, an effective treatment has remained elusive for four decades due to the successful immune evasion mechanisms of the virus. A thorough understanding of the molecular interaction of HIV with the host cell is essential in the development of both preventive and curative therapies for HIV infection. This review highlights several inherent mechanisms of HIV that promote its survival and propagation, such as the targeting of CD4+ lymphocytes, the downregulation of MHC class I and II, antigenic variation and an envelope complex that minimizes antibody access, and how they collaboratively render the immune system unable to mount an effective response.

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“…IL-6, IL-8 and tumor necrosis factor (TNF)-α may be biomarkers of AIH activity. HLA gene expression may play a role in the production of cytokines, and enable earlier diagnosis and better treatment[ 12 ]. Recent studies have reported that AIH I in Dutch adults is associated with mutations in the MHC region, and identified sh2b3 and card10 mutations as possible risk factors.…”

Section: Genetic Predispositionmentioning

confidence: 99%

Pathogenesis of autoimmune hepatitis

Fan¹,

Liu²,

Lv³

et al. 2021

WJH

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Autoimmune hepatitis (AIH) is a chronic progressive liver disease whose etiology and pathogenesis are not yet clear. It is currently believed that the occurrence of AIH is closely related to genetic susceptibility and immune abnormalities, and other factors such as environment, viral infection and drugs that may cause immune dysfunction. This article reviews the pathogenesis of AIH and describes the latest research results in the past 5 years.

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High levels of proinflammatory cytokines IL-6, IL-8, TNF-Α, IL-23, and IFN- in Tunisian patients with type 1 autoimmune hepatitis

Cited by 14 publications

References 33 publications

Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

HIV–Host Cell Interactions

Pathogenesis of autoimmune hepatitis

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