HIV–Host Cell Interactions

Masenga, Sepiso K.; Mweene, Bislom C.; Luwaya, Emmanuel; Muchaili, Lweendo; Chona, Makondo; Kirabo, Annet

doi:10.3390/cells12101351

Cited by 10 publications

(2 citation statements)

References 290 publications

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“…The expression of CXCR4 in cardiomyocytes, endothelial cells, and smooth muscle cells could be detected on the surface of stem cells [ 29 ]. The initial function of CXCR4 discovered is in HIV infection [ 30 ] and cancer cell metastasis [ 31 ]; its role in development is also very important [ 29 ]. During embryogenesis, CXCR4 expressed highly as a chemokine receptor and controls directional migration in many cases.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence

Zheng

Zhao

Wang

et al. 2023

IJMS

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Many processes take place during embryogenesis, and the development of the palate mainly involves proliferation, migration, osteogenesis, and epithelial–mesenchymal transition. Abnormalities in any of these processes can be the cause of cleft palate (CP). There have been few reports on whether C-X-C motif chemokine receptor 4 (CXCR4), which is involved in embryonic development, participates in these processes. In our study, the knockdown of Cxcr4 inhibited the migration of mouse embryonic palatal mesenchymal (MEPM) cells similarly to the use of its inhibitor plerixafor, and the inhibition of cell migration in the Cxcr4 knockdown group was partially reversed by supplementation with C-X-C motif chemokine ligand 12 (CXCL12). In combination with low-dose retinoic acid (RA), plerixafor increased the incidence of cleft palates in mice by decreasing the expression of Cxcr4 and its downstream migration-regulating gene Rac family small GTPase 1 (RAC1) mediating actin cytoskeleton to affect lamellipodia formation and focal complex assembly and ras homolog family member A (RHOA) regulating the actin cytoskeleton to affect stress fiber formation and focal complex maturation into focal adhesions. Our results indicate that the disruption of cell migration and impaired normal palatal development by inhibition of Cxcr4 expression might be mediated through Rac1 with RhoA. The combination of retinoic acid and plerixafor might increase the incidence of cleft palate, which also provided a rationale to guide the use of the drug during conception.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence

Zheng

Zhao

Wang

et al. 2023

IJMS

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“…HIV destroys the human antiviral defense system and promotes the development of cancer. The virus may carry oncogenes that can then be integrated into the DNA of host cells, causing the cells to undergo cancerous transformation, especially when the immune system is suppressed and immune surveillance is lost ( 49 ). Anti-HIV management is an important topic in the field of clinical treatment and medical research.…”

Section: Antiviral Properties Of Melittinmentioning

confidence: 99%

The current landscape of the antimicrobial peptide melittin and its therapeutic potential

Zhang,

Sun,

et al. 2024

Front. Immunol.

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Melittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-helix structure. It has been reported that melittin can exert pharmacological effects, such as antitumor, antiviral and anti-inflammatory effects in vitro and in vivo. In particular, melittin may be beneficial for the treatment of diseases for which no specific clinical therapeutic agents exist. Melittin can effectively enhance the therapeutic properties of some first-line drugs. Elucidating the mechanism underlying melittin-mediated biological function can provide valuable insights for the application of melittin in disease intervention. However, in melittin, the positively charged amino acids enables it to directly punching holes in cell membranes. The hemolysis in red cells and the cytotoxicity triggered by melittin limit its applications. Melittin-based nanomodification, immuno-conjugation, structural regulation and gene technology strategies have been demonstrated to enhance the specificity, reduce the cytotoxicity and limit the off-target cytolysis of melittin, which suggests the potential of melittin to be used clinically. This article summarizes research progress on antiviral, antitumor and anti-inflammatory properties of melittin, and discusses the strategies of melittin-modification for its future potential clinical applications in preventing drug resistance, enhancing the selectivity to target cells and alleviating cytotoxic effects to normal cells.

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Power-series solutions of fractional-order compartmental models

Jornet

2024

Comp. Appl. Math.

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Compartmental models based on coupled differential equations of fractional order have been widely employed in the literature for modeling. An abstraction of these models is given by a system with polynomial vector field. We investigate the use of power series for solving generic polynomial differential equations in any dimension, with Caputo fractional derivative. As is well known, power series convert a continuous formulation into a discrete system of difference equations, which are easily solved by recursion. The novelty of this paper is that we rigorously prove that the series converge on a neighborhood of the initial instant, which is an analogue of the Cauchy–Kovalevskaya theorem. Besides, these series are proved to be continuous with respect to the fractional index. For applications, a general-purpose symbolic implementation of truncated power series is developed, and its execution is illustrated for the fractional SIR epidemiological model.

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HIV–Host Cell Interactions

Cited by 10 publications

References 290 publications

Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence

Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence

The current landscape of the antimicrobial peptide melittin and its therapeutic potential

Power-series solutions of fractional-order compartmental models

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