High levels of organochlorine pesticides in drinking water as a risk factor for type 2 diabetes: A study in north India

Tyagi, S.; Siddarth, Manushi; Mishra, B.K.; Banerjee, Basu Dev; Urfi, Abdul Jamil; Madhu, Sri Venkata

doi:10.1016/j.envpol.2020.116287

Cited by 30 publications

(12 citation statements)

References 63 publications

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“…Thus, OCPs were considered as one of the original 12 persistent organic pollutants according to the Stockholm Convention [ 8 ], and the United States (U.S.) Environmental Protection Agency restricted and banned the use of most OCPs during the 1970s and 1980s [ 9 ]. Although these chemicals are rarely used in the U.S. nowadays, OCPs remain ubiquitously exposed and can also be detected in the environment and human tissues; they are known to be lipophilic, bio-accumulative and resistant to environmental degradation [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016

Wang

et al. 2022

IJERPH

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The current study aimed to investigate temporal trends of serum organochlorine pesticide (OCP) concentrations in the general United States population, approximately 30 years after the prohibition of OCP usage, by using National Health and Nutrition Examination Survey data. The least square geometric means and percent change in OCP concentrations were calculated by a survey weighted multiple linear regression model. Over 2005–2016, OCP concentrations showed significant downward temporal trends. Females had substantially higher concentrations of β-Hexachlorocyclohexane (β-HCH), p,p′-DDE and p,p′-DDT, but lower concentrations of Hexachlorobenzene (HCB) and trans-nonachlor. In addition, females had a more rapid decrease in p,p′-DDT levels over time than males. The overall OCP concentrations increased with age, and the two oldest age groups (aged 40–59 and 60+ years) had substantially lower rates of decrease than the younger age groups (aged 12–39 years). Concentrations and declines in OCPs (except for trans-nonachlor) were higher in Mexican Americans than both non-Hispanic Whites and non-Hispanic Blacks. There is a particular need for the ongoing monitoring of these banned chemicals, and measures should be taken to mitigate the exposure of vulnerable populations, including adults aged over 60, Mexican Americans, females for β-HCH, p,p′-DDE and p,p′-DDT, and males for HCB and trans-nonachlor.

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Section: Introductionmentioning

confidence: 99%

Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016

Wang

et al. 2022

IJERPH

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“…Pada tabel 1 (Chudchawal, Yuwayong, Juntarawijit1, & Juntarawijit1, 2018;Hansen et al, 2020). Pada negara India ditemukan hubungan yang signifikan antara kadar organoklorin dalam air dan kadar organoklorin darah (Tyagi et al, 2021). Sumber pajanan pestisida juga ditemukan pada makanan seperti pada ikan dan buah-buahan di Ontario (Marushka et al, 2018).…”

Section: Study Terpilihunclassified

“…Sebanyak 7 dari 10 penelitian melakukan deteksi organoklorin melalui serum yang kemudian dianalisis menggunakan chromatography gas, namun ada pula yang menggunakan kuesioner untuk menentukan pajanan pestisida terhadap diabetes (Son et al, 2010) (Chudchawal et al, 2018) Pada penelitian yang dilakukan di India Timur menemukan kadar organoklorin yang tinggi di air tanah dengan konsentrasi rata-rata (0.0061 mg/l ± 0.024 mg/l) dan median 0.070 mg/l.. Kadar o, p'-DDT berkisar antara 0,520 ppb hingga 1,44 ppb dalam air keran, 0,648 ppb hingga 1,79 ppb dalam air tanah, dan 0,486 ppb hingga 1,07 ppb dalam sampel air filter. Kadar p, p'-DDE dan o, p'-DDT juga ditemukan lebih tinggi pada pra-diabetes dan penderita diabetes melitus tipe-2 (DMT2) (Tyagi et al, 2021). Pada sebuah penelitian case control yang melibatkan 180 orang partisipan mendeteksi kadar pestisida seperti oxychlordane, trans-Nonachlor, β-Hexachlorocyclohexane, p,p´-DDE dan Mirex menunjukan hasil yang lebih tinggi pada usia 20-36 tahun beberapa pestisida menunjukan dampak yang positif terhadap risiko diabetes tipe-2 seperti transnonachlor dengan nilai (OR= 3.3 CI 95%), oxychlordane (OR= 1.7 CI 95%) (Son et al, 2010) (Lee, Song, et al, 2006) (Lee et al, 2007).…”

Section: Study Terpilihunclassified

“…dimana kelompok yang mengkonsumsi air tanah memiliki kadar glukosa lebih tinggi dibandingkan dengan kelompok yang mengkonsumsi air saring. penggunaan air tanah yang tercemar organoklorin dalam jangka panjang untuk minum selama lebih dari sepuluh tahun dapat meningkatkan risiko pengembangan intoleransi glukosa dan resistensi insulin, yang meningkatkan risiko pengembangan DMT2 (Tyagi et al, 2021). Pada sebuah penelitian case control yang melibatkan 180 orang partisipan mendeteksi serum organoklorin pada subyeknya menunjukan hasil yang lebih tinggi pada usia 20-36 tahun beberapa pestisida menunjukan dampak yang positif terhadap risiko DMT2 seperti Oxychlordane dan trans-nonachlor yang menunjukkan hubungan yang kuat dengan risiko diabetes di masa depan, beberapa jenis pestisida juga dapat mengganggu metabolisme lipid selama periode pengamatan yang lama (Lee et al, 2010).…”

Section: Pembahasanunclassified

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Pajanan Pestisida Organoklorin Terhadap Diabetes Melitus Tipe-2 Pada Usia Muda: Tinjauan Literatur

Husna

Hartono

2021

PREPOTIF

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DMT2 is the most common type of diabetes in the world. In developed countries, dia¬betes affects people over 65 years old. However, in Asia, the younger generation is also affected and the age onset of diabetes has declined. Several factors that may lead to early diabetes is changes in consumption and activity patterns. However, that should be noted that pestisides expusure by food and environmental pollutants can even be the reason behind the increasing incidence of type-2 diabetes mellitus. This study aims to provide a systematic review of the impact of pesticide exposure on the incidence of type-2 diabetes, especially at a young age. We performed articles search using Science Direct, Spinger Link, ProQuest, Pubmed and Scopus databases published since 2010 until 2020. In total, 10 scientific articles included in this study. Pesticide exposure is determined by the nature of the sources. Most studies showed a strong association between organochlorine pesticides and also the incidence of diabetes. The average age of the entire study was 43 years this has proven that there is a decrease in the onset of age of people with DMT2 in Asia. The results show that organochlorine pesticides had an impact on the incidence of DMT2 at a younger age. Someone with high levels of organochlorines serum will had a high blood glucose levels. Race may also effect the incidence of diabetes, it need to be assessed experimentally.

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“…Exposure to environmental toxicants such as organochlorine pesticides (OCPs) has been strongly associated with type 2 diabetes mellitus (T2DM) ( 1 – 6 ). Their property of persistence and bioaccumulation in the environment has generated a surge of global interest ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Organochlorine Pesticides With Genetic Markers of Endoplasmic Reticulum Stress in Type 2 Diabetes Mellitus: A Case–Control Study Among the North-Indian Population

et al. 2022

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BackgroundOrganochlorine pesticides (OCPs) have been long linked to type 2 diabetes mellitus (T2DM); however, this relation at the molecular level has not been explored yet. Endoplasmic reticulum (ER) stress and pro-inflammatory pathways are considered vital ones in the pathogenesis of T2DM. We aimed to investigate the existence of any association between OCPs, ER stress, and pro-inflammatory pathways in subjects with known T2DM.MethodsSeventy subjects each with T2DM and normal glucose tolerance were recruited from the surgery department. Their visceral adipose tissue was collected intraoperatively. OCP concentration, ER stress, and pro-inflammatory markers were analyzed and compared between two study groups.ResultsWe found 18 OCPs and their metabolites in visceral adipose tissue samples of study participants. The levels of δ-HCH, heptachlor, endrin, and p,p′DDT were significantly higher in the T2DM group and were also positively correlated with fasting and postprandial plasma glucose levels (p < 0.01). We observed a positive association of δ-HCH (p < 0.01), heptachlor (p < 0.05), and endrin (p < 0.05) with central adiposity and ER stress markers. However, we failed to establish the correlation of OCPs with any of the pro-inflammatory markers.ConclusionThe existence and simultaneous complex correlation of OCPs with ER stress may explain their role in the pathogenesis of T2DM, revealing the persistence of the gene–environment interaction in the etiology of T2DM.

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High levels of organochlorine pesticides in drinking water as a risk factor for type 2 diabetes: A study in north India

Cited by 30 publications

References 63 publications

Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016

Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016

Pajanan Pestisida Organoklorin Terhadap Diabetes Melitus Tipe-2 Pada Usia Muda: Tinjauan Literatur

Association of Organochlorine Pesticides With Genetic Markers of Endoplasmic Reticulum Stress in Type 2 Diabetes Mellitus: A Case–Control Study Among the North-Indian Population

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