High Levels of Nitric Oxide Synthase Activity are Associated with Nasal Polyp Tissue from Aspirin-sensitive Asthmatics

Parikh, Abhi; Scadding, Guy; Gray, P A; Belvisi, Maria G.; Mitchell, Jane A.

doi:10.1080/000164802753648204

Cited by 23 publications

(16 citation statements)

References 14 publications

(9 reference statements)

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“…This is supported by the finding of raised nNO following medical and surgical [65] treatment of rhinosinusitis with or without polyps.…”

Section: Nasal Nitric Oxidementioning

confidence: 74%

“…nNO has a potential role in the diagnosis and assessment of CRS, especially when associated with NP. Interestingly, despite the increased expression of iNOS in polyp epithelium [65], low nNO levels have been found in two large studies [66]. Moreover, nNO inversely correlated with endoscopic NP size, CT scores and clinical severity of disease [67].…”

Section: Nasal Nitric Oxidementioning

confidence: 99%

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Diagnostic tools in Rhinology EAACI position paper

Scadding

Hellings²,

Alobid³

et al. 2011

Clinical & Translational All

187

173

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This EAACI Task Force document aims at providing the readers with a comprehensive and complete overview of the currently available tools for diagnosis of nasal and sino-nasal disease. We have tried to logically order the different important issues related to history taking, clinical examination and additional investigative tools for evaluation of the severity of sinonasal disease into a consensus document. A panel of European experts in the field of Rhinology has contributed to this consensus document on Diagnostic Tools in Rhinology.

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“…This is supported by the finding of raised nNO following medical and surgical [65] treatment of rhinosinusitis with or without polyps.…”

Section: Nasal Nitric Oxidementioning

confidence: 74%

Section: Nasal Nitric Oxidementioning

confidence: 99%

Diagnostic tools in Rhinology EAACI position paper

Scadding

Hellings²,

Alobid³

et al. 2011

Clinical & Translational All

187

173

View full text Add to dashboard Cite

show abstract

“…Parikh et al [66] found that NOS activity was also enhanced in nasal polyps from aspirin-sensitive asthmatics. Therefore, they formulated the hypothesis that the overproduction of cytokines occurring in aspirin-sensitive patients stimulates NOS-2 expression, thus promoting an elevated synthesis of NO.…”

Section: Nasal Polyposismentioning

confidence: 99%

Nitric oxide in upper airways inflammatory diseases

2007

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In the human respiratory tract, the main production sites of exhaled nitric oxide (NO) are the nose and paranasal sinuses. In the upper airways, NO has been suggested to be involved at different levels with regulatory, protective, defensive or deleterious effects. Therefore, we review some aspects of the origin, metabolism, and functions of NO in the upper airways, together with the role of NO in some upper airways inflammatory diseases. Furthermore, we discuss the recent improvements in nasal NO measurements, which may be useful to better characterize the involvement of the NO produced by nose and paranasal sinuses in upper airways inflammatory diseases such as allergic rhinitis, nasal polyposis, sinusitis, primary ciliary dyskinesia, and cystic fibrosis.

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“…Elevated levels of oral and nasal FeNO (fractional concentration of exhaled nitric oxide) were shown to be associated with overexpression of NOS-2, and are specific for eosinophilic chronic rhinosinusitis [32]. Parikh et al [33] observed that the activity of NOS-2 in eosinophilic polyps of patients with asthma and aspirin sensitivity was significantly higher than in nasal polyps of persons without asthma or with asthma without aspirin sensitivity. We observed an overexpression of NOS-2 in tissues of both eosinophilic and neutrophilic polyps.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of tumor necrosis factor α, interleukin 1β, nuclear factor κB in nasal mucosa among chronic rhinosinusitis patients with and without polyps

Plewka¹,

Grzanka²,

Drzewiecka³

et al. 2017

pdia

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Differential expression of tumor necrosis factor α, interleukin 1β, nuclear factor κB in nasal mucosa among chronic rhinosinusitis patients with and without polyps A b s t r a c t Introduction: The pathogenesis of nasal polyps is still not fully understood. Aim: To analyze the topography and intensity of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), cyclooxygenase 2 (COX-2), nitric oxide synthase 2 (NOS-2), and nuclear factor-κB (NF-κB) expressions in eosinophilic and neutrophilic polyps and in normal nasal mucosa. Material and methods: The study included specimens from 20 patients with eosinophilic polyps (more than 10% of eosinophils in inflammatory infiltrate), 20 individuals with neutrophilic polyps (predominance of neutrophils and less than 10% of eosinophils), and samples of normal nasal mucosa from 10 controls. The expressions of studied proteins in vascular endothelial cells, epithelial, stromal and glandular cells were determined immunohistochemically with specific monoclonal antibodies. Results: Irrespective of the cellular type, the intensity of expressions in eosinophilic and neutrophilic polyps was significantly higher than in the normal mucosa. Eosinophilic polyps were characterized by stronger expressions of TNF-α (in all cellular types), IL-1β (in endothelial, glandular and epithelial cells), NF-κB (in stromal and epithelial cells), COX-2 (in glandular and stromal cells), and NOS-2 (in endothelial and stromal cells). In contrast, neutrophilic polyps showed significantly stronger expressions of COX-2 (in epithelial and endothelial cells) and NOS-2 (in glandular and epithelial cells). In both phenotypes, the strongest expressions of all studied markers were documented in vascular endothelial cells. Conclusions: Inflammatory markers are involved in pathogenesis of both eosinophilic and neutrophilic polyps. Endothelial defects can play an important role in the development of nasal polyps.

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High Levels of Nitric Oxide Synthase Activity are Associated with Nasal Polyp Tissue from Aspirin-sensitive Asthmatics

Cited by 23 publications

References 14 publications

Diagnostic tools in Rhinology EAACI position paper

Diagnostic tools in Rhinology EAACI position paper

Nitric oxide in upper airways inflammatory diseases

Differential expression of tumor necrosis factor α, interleukin 1β, nuclear factor κB in nasal mucosa among chronic rhinosinusitis patients with and without polyps

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