High Levels of Low-Density Lipoproteins Correlate with Improved Survival in Patients with Squamous Cell Carcinoma of the Head and Neck

Wilms, Torben; Boldrup, Linda; Gu, Xiaolian; Coates, Philip J.; Sgaramella, Nicola; Nylander, Karin

doi:10.3390/biomedicines9050506

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…The results of this study show that a high level of LDL‐C benefits the prognosis of patients with HNSCC. This is consistent with previous research findings (Wilms et al, 2021). And a low level of Apo A‐I, an important component of HDL‐C, was found to indicate a better prognosis for HNSCC patients.…”

Section: Discussionsupporting

confidence: 94%

“…But their relationship with HNSCC is not yet clear. High levels of Apo A‐I are associated with a poor prognosis in HNSCC (Li et al, 2016), while the functions of cholesterol, HDL‐C, and LDL‐C in HNSCC are inconsistent (Dickinson et al, 2020; Li et al, 2016; Liu et al, 2021; Wilms et al, 2021). Therefore, a comprehensive understanding of the correlation between serum lipid profile and the prognosis of HNSCC is required.…”

Section: Introductionmentioning

confidence: 99%

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Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma

Wang

et al. 2022

Oral Diseases

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PurposeThis study aims to clarify whether blood lipid profiles are indicators of prognosis in patients with head and neck squamous cell carcinoma (HNSCC).MethodsThis retrospective study included 512 T1/2N0M0 HNSCC patients. The correlation between blood lipid profiles and progression‐free survival (PFS) and disease‐specific survival (DSS) was analyzed by multivariate analysis. The data from TCGA was also analyzed to investigate the expression levels and prognostic values of different lipoprotein receptors essential for specific lipid uptake.ResultsA high level of low‐density lipoprotein cholesterol (LDL‐C) indicated better PFS and DSS, and a low level of apolipoprotein A‐I (Apo A‐I) indicated better PFS, while a high level of apolipoprotein B (Apo B) indicated poorer PFS and DSS. The Apo A‐I receptor gene SCARB1 was upregulated and associated with poor survival in HNSCC patients. Activation of SCARB1 was implicated in a series of tumor‐promoting pathways. There was no significant correlation between the expression of LDL‐C and Apo B‐related receptors and prognosis.ConclusionA high level of LDL‐C and a low level of Apo A‐I are protective factors for HNSCC, while a high level of Apo B is a risk factor. The upregulation of SCARB1 may participate in the progression of HNSCC.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma

Wang

et al. 2022

Oral Diseases

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“…In this way, a conclusion that high serum LDL-C levels may exist as a favorable predictor for CSS in patients with CCRCC was made. In some other studies, the conclusions were consistent with that of this current study in which a high serum LDL-C may function as a favorable predictor in the corresponding cancers, such as non-esophageal squamous cell carcinoma ( 31 ), squamous cell carcinoma of the head and neck ( 32 ) and peripheral T-cell lymphoma ( 33 ).…”

Section: Discussionsupporting

confidence: 92%

Preoperative low-density lipoprotein cholesterol as a predictor of favorable prognosis in patients with clear cell renal cell carcinoma

Mei¹,

Chen²,

Wang³

et al. 2023

Transl Cancer Res

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Background Studies have shown that dyslipidemia is closely tied to a variety of cancers, and the level of low-density-lipoprotein-cholesterol (LDL-C) is related to the prognosis of cancer patients. However, what remains unclear is the predictive meaning of LDL-C among patients who suffer from renal cell carcinoma, especially clear cell renal cell carcinoma (CCRCC). The aim of this study was to investigate the correlation between the preoperative levels of serum LDL-C and the prognosis of surgical patients who suffer from clear cell renal cell carcinoma. Methods A total of 308 CCRCC patients that received radical or partial nephrectomy were retrospectively included in this study. The clinical data of each included patient were collected. Overall survival (OS) and cancer-specific survival (CSS) were calculated using Kaplan-Meier method and Cox proportional hazards regression model. Results Univariate analysis showed that a higher LDL-C level indicated a better OS and CSS in CCRCC patients (P=0.002 and P=0.001, respectively). The same was shown in the Multivariate analysis that a higher LDL-C level indicated a better OS and CSS in CCRCC patients (P<0.001 and P<0.001, respectively). Following propensity score matching (PSM) analysis, a higher LDL-C level still existed as an ideal indicator for both OS and CSS. Conclusions The study indicated that a higher serum level of LDL-C showed clinical significance for predicting better OS and CSS in patients with CCRCC.

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“…28 There was a negative correlation between high-density lipoprotein or low-density lipoprotein cholesterol and increased risk of cancers, including nasopharyngeal cancer, 29,30 but some studies have different results. 31 Total lymphocyte count is an indicator of immunological status. 32,33 Low peripheral lymphocyte count leads to insufficient host immune response to cancer cells and intolerance to chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Preoperative Controlling Nutritional Status in Hypopharyngeal Cancer Patients Undergoing Surgery-Oriented Comprehensive Treatment

Ding

Liu

et al. 2023

Ear Nose Throat J

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Objectives The preoperative controlling nutritional status (pCONUT) score has been shown correlated with the prognosis of some cancerous diseases; however, little is known about the effect of pCONUT score on hypopharyngeal cancer (HPC). Therefore, the objective of our study was to demonstrate the relationship between the pCONUT score and the clinical outcome of patients with HPC. Patients and Methods Ninety-four patients with HPC who underwent surgery between May 2012 and Dec 2020 were enrolled in this study. We evaluated retrospectively their pCONUT scores and calculated the cutoff value regarding the patients’ overall survival using the X-tile software. Kaplan–Meier and Cox proportional hazard regression model were used to determine how the pCONUT score affected overall survival. Results A cutoff level of 4 was determined to be optimal for the pCONUT score, by which the patients were grouped into high pCONUT score (≥4, n = 22, 23.4%) or low pCONUT score (<4, n = 72, 76.6%) groups. The univariate analysis showed that high pCONUT scores correlated with reduced overall survival (hazard ratio: 2.925, 95% confidence interval: 1.526-5.607, P = .001). Furthermore, the multivariate analysis also showed that high pCONUT scores increased the risk of overall death (hazard ratio: 2.639, 95% confidence interval: 1.365-5.101, P = .004). Conclusions The pCONUT score is considered a useful prognostic factor in patients with HPC.

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High Levels of Low-Density Lipoproteins Correlate with Improved Survival in Patients with Squamous Cell Carcinoma of the Head and Neck

Cited by 6 publications

References 35 publications

Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma

Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma

Preoperative low-density lipoprotein cholesterol as a predictor of favorable prognosis in patients with clear cell renal cell carcinoma

Prognostic Value of Preoperative Controlling Nutritional Status in Hypopharyngeal Cancer Patients Undergoing Surgery-Oriented Comprehensive Treatment

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