High levels of exposure of Zika and Dengue infections detected using plaque reduction neutralization assay in Brazil

Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR. Our study confirmed ZIKV infection in 4.9% of patients with clinical dengue symptoms and in 8.6% of persons who were asymptomatic. This is the first report on ZIKV infection in Myanmar and it suggests the occurrence of ZIKV infection in two geographically distinct sites in this country since at least 2006.

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“…In our recent study 8 and in other published studies, 18,19 both PRNT50 and FRNT50 were used for DENV, JEV, and ZIKV neutralization tests.…”

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confidence: 99%

Detection of Zika Virus Infection in Myanmar

Tun

Kyaw

Hmone

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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High levels of exposure of Zika and Dengue infections detected using plaque reduction neutralization assay in Brazil

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Detection of Zika Virus Infection in Myanmar

Detection of Zika Virus Infection in Myanmar

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