High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women

Sveen, Kari Anne; Smith, Gustav; Björkbacka, Harry; Orho‐Melander, Marju; Engström, Gunnar; Gonçalves, Isabel; Melander, Olle; Nilsson, Jan; Bengtsson, Eva

doi:10.1111/joim.13393

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…On the other hand, Sjögren et al found that the presence of anti-IgG antibodies against the native peptide 210 of ApoB100 is associated with a reduced risk of CHD [62]. Intriguingly, high levels of p210 ApoB100 antibodies have been linked to a lower incidence of atrial fibrillation in female subjects [63]. These antibodies seem to enhance cholesterol efflux by macrophages.…”

Section: Autoantibodies Against Apob100: a Novel Biomarker Of The Vul...mentioning

confidence: 99%

ApoB100 and Atherosclerosis: What’s New in the 21st Century?

Kounatidis,

Vallianou,

Poulaki

et al. 2024

Metabolites

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ApoB is the main protein of triglyceride-rich lipoproteins and is further divided into ApoB48 in the intestine and ApoB100 in the liver. Very low-density lipoprotein (VLDL) is produced by the liver, contains ApoB100, and is metabolized into its remnants, intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL). ApoB100 has been suggested to play a crucial role in the formation of the atherogenic plaque. Apart from being a biomarker of atherosclerosis, ApoB100 seems to be implicated in the inflammatory process of atherosclerosis per se. In this review, we will focus on the structure, the metabolism, and the function of ApoB100, as well as its role as a predictor biomarker of cardiovascular risk. Moreover, we will elaborate upon the molecular mechanisms regarding the pathophysiology of atherosclerosis, and we will discuss the disorders associated with the APOB gene mutations, and the potential role of various drugs as therapeutic targets.

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Section: Autoantibodies Against Apob100: a Novel Biomarker Of The Vul...mentioning

confidence: 99%

ApoB100 and Atherosclerosis: What’s New in the 21st Century?

Kounatidis,

Vallianou,

Poulaki

et al. 2024

Metabolites

View full text Add to dashboard Cite

show abstract

“…It was shown that increased levels of IgM against apoB100 p210 were independently associated with a decreased risk of AF development but only in women. Moreover, the association between IgM and AF was significantly different between sexes even after adjusting risk factors and comorbidities [57]. All studies discussed in this section have been summarized in Table 5.…”

Section: Research Investigating Other Types Of Autoantibodiesmentioning

confidence: 99%

Autoantibodies in Atrial Fibrillation—State of the Art

Zygadło

Procyk

Balsam

et al. 2023

IJMS

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Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. To date, a lot of research has been conducted to investigate the underlying mechanisms of this disease at both molecular and cellular levels. There is increasing evidence suggesting that autoimmunity is an important factor in the initiation and perpetuation of AF. Autoantibodies are thought to play a pivotal role in the regulation of heart rhythm and the conduction system and, therefore, are associated with AF development. In this review, we have summarized current knowledge concerning the role of autoantibodies in AF development as well as their prognostic and predictive value in this disease. The establishment of the autoantibody profile of separate AF patient groups may appear to be crucial in terms of developing novel treatment approaches for those patients; however, the exact role of various autoantibodies in AF is still a matter of ongoing debate.

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“…As the native or malonaldehyde-modified peptide, apoB100 peptide 210 (p210) is known as extremely immune recognized epitopes. In the Malmö Diet and Cancer cohort study, compared with the first quartile of IgM against p210, females with the fourth quartile of IgM against native p210 had a lower risk of the development of AF (adjusted HR 0.67, 95% CI 0.49–0.91, p = 0.01) [ 40 ].…”

Section: Lipid Subtypes Disorders and Afmentioning

confidence: 99%

Lipid Profile and Atrial Fibrillation: Is There Any Link?

Jiang¹,

Yang²,

Chen³

et al. 2022

Rev. Cardiovasc. Med.

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Atrial fibrillation (AF) is the most common type of symptomatic arrhythmias, which was induced by multiple causes and dyslipidemia is a well-known causal factor for the atherosclerotic cardiovascular disease (ASCVD). Interestingly, emerging data has suggested that lipid disorder may be also associated with AF. Several previous studies have shown a link of the prevalence of AF with decreased concentration of low-density lipoproteins (LDL)-cholesterol, total cholesterol (TC), high-density lipoproteins (HDL)-cholesterol, and elevated lipoprotein(a) [Lp(a)]. In this manuscript, we try to summarize the current evidence regarding the relation of dyslipidemia to the incident AF, present the potential lipid-related mechanisms of AF development, which is involved in cell membrane properties, LDL-receptors reduction, reverse cholesterol transport, adiposity-induced inflammation, apoptosis, and autophagy. Such information may boost our understandings concerning the lipid disorder and AF, which may help future exploration in the link of dyslipidemia and AF.

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High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women

Abstract: High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women.

Cited by 4 publications

References 33 publications

ApoB100 and Atherosclerosis: What’s New in the 21st Century?

ApoB100 and Atherosclerosis: What’s New in the 21st Century?

Autoantibodies in Atrial Fibrillation—State of the Art

Lipid Profile and Atrial Fibrillation: Is There Any Link?

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