High-level and novel mechanisms of carbapenem resistance in Gram-negative bacteria from tertiary hospitals in Nigeria

Ogbolu, David Olusoga; Webber, Mark A.

doi:10.1016/j.ijantimicag.2014.01.014

Cited by 51 publications

(50 citation statements)

References 19 publications

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“…These drugs are the last-line drugs in therapy of infections; resistance to carbapenems is an emerging concern in human medicine. In a study by Ogbolu et al [55], carbapenem resistance with novel mechanisms of resistance was detected among Gram-negative bacterial isolates from hospital infections. No data exists on community isolates exhibiting resistance to carbapenems in Nigeria; however, studies have documented resistance to carbapenems in Enterobacteriaceae in other parts of the world among community isolates [56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and multidrug resistance of Escherichia coli from community-acquired infections in Lagos, Nigeria

Adenipekun

Jackson

Ramadan

et al. 2016

J Infect Dev Ctries

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Introduction: The emergence of multidrug resistance (MDR; resistance to ≥ 2 more antimicrobials) in Escherichia coli is of concern due to complications encountered in treatment. Methodology: In this study, prevalence, antimicrobial resistance, and genetic characteristics of MDR community isolates of E. coli from Lagos, Nigeria were determined. Urine and stool samples were obtained from outpatients attending Lagos State hospitals and from animal handlers in abattoirs, poultries, and open markets, from December 2012 to July 2013.Results: Approximately 50% of urine (200/394) and 88% of stool samples (120/136) were positive for E. coli. Based upon β-lactamase production, a subset of those isolates was selected for further study. Of the 22 antimicrobials tested, E. coli exhibited resistance to all antimicrobials except amikacin and piperacillin/tazobactam. The highest levels of resistance were to tetracycline (182/247; 73.7%), trimethoprim/sulfamethoxazole (152/247; 61.5%), and ampicillin (147/247; 59.1%). Resistance to the cephalosporins ranged from 1.6%-15% including the third-and fourth-generation cephalosporins, cefpodoxime (20/247; 8.1%) and cefepime (4/247; 1.6%), respectively. MDR was observed in 69.6% (172/247) of the isolates. Forty-eight E. coli resistant to at least five antimicrobials were selected for further analysis using pulsed-field gel electrophoresis; seven distinct clusters were observed among the diverse patterns. Of the 48 MDR E. coli, 30 different sequence types (ST) were detected using multilocus sequence typing, including four ST131. Conclusions: This study demonstrated circulating MDR E. coli in the Nigerian community. Monitoring of antimicrobial resistance in developing countries is necessary to optimize empiric treatment and the prudent use of antimicrobials.

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Section: Discussionmentioning

confidence: 99%

Prevalence and multidrug resistance of Escherichia coli from community-acquired infections in Lagos, Nigeria

Adenipekun

Jackson

Ramadan

et al. 2016

J Infect Dev Ctries

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“…In the case of patients at risk, this can involve the extension of the disease or even death [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

et al. 2015

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New series of hydrazones 5-18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (−) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14-16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules.

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“…Recent studies have shown the dissemination of both of these genes from India to other countries (Castanheira et al, 2011). In Nigeria, not much work has been done on the molecular identification and characterization of carbapenemase genes, however their existence in the country has been established in some studies (Olaitan et al, 2013;Ogbolu and Webber, 2014).…”

mentioning

confidence: 99%

“…The presence of carbapenemase genes had been established previously in Nigeria (Olaitan et al, 2013;Ogbolu and Webber, 2014).…”

mentioning

confidence: 99%

First report of OXA-181 and NDM-1 from a clinical Klebsiella pneumoniae isolate from Nigeria

Uwaezuoke

Kieffer

Iregbu

et al. 2017

International Journal of Infectious Diseases

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High-level and novel mechanisms of carbapenem resistance in Gram-negative bacteria from tertiary hospitals in Nigeria

Cited by 51 publications

References 19 publications

Prevalence and multidrug resistance of Escherichia coli from community-acquired infections in Lagos, Nigeria

Prevalence and multidrug resistance of Escherichia coli from community-acquired infections in Lagos, Nigeria

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

First report of OXA-181 and NDM-1 from a clinical Klebsiella pneumoniae isolate from Nigeria

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