High-ionic-strength pre-concentration via ion concentration polarization for blood-based biofluids

Han, Sung Il; Yoo, Yong Kyoung; Lee, Junwoo; Kim, Cheonjung; Lee, Kyung-Jae; Lee, Tae Hoon; Kim, Hyungsuk; Yoon, Dae Sung; Hwang, Kyo Seon; Kwak, Rhokyun; Lee, Jeong Hoon

doi:10.1016/j.snb.2018.04.144

Cited by 35 publications

(26 citation statements)

References 46 publications

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“…Han et al . demonstrated the use of a paper‐based preconcentrator to achieve ICP preconcentration of blood biological fluid (serum) and an approximately five‐fold increase in the effective preconcentration factor for all prepared human serum samples . Marczak et al .…”

Section: Applications Of Ion Transport Based On Icpmentioning

confidence: 99%

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Han

Chen

2019

J of Chemical Tech & Biotech

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Lab-on-a-chip has been used widely in rapid, high-throughput and low-consumption analysis of samples in biochemistry. The ion concentration polarization (ICP) produced by ion-selective transport of nanochannels provides a novel solution for problems in ultra-low concentration sample detection, systems biology and desalination. This paper reviews the applications of ion transport based on the principle of ICP in micro-nanofluidic systems. First, the fundamental governing equations of ICP are described. Then, the applications of nano-electrokinetic ion enrichment and ion current rectification (ICR) are introduced. Nano-electrokinetic ion enrichment is used mainly in the fields of molecular enrichment, ultra-low concentration sample detection and seawater desalination. ICR is applied mainly to the sensitive detection of analytical substances such as proteins, nucleic acids and small molecules. The application of ion transport based on ICP principle is summarized and the possible directions worthy of further research are proposed.

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Section: Applications Of Ion Transport Based On Icpmentioning

confidence: 99%

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Han

Chen

2019

J of Chemical Tech & Biotech

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“…Another approach is to separate/preconcentrate the exosome using a microfluidic platform. We have shown that the use of a microfluidic paper-based analytical device chip with preconcentrating function, yields a 5-fold increase in preconcentrating factors under blood-based biofluids (serum) [104,105]. Based on this technique, our group is now trying to separate and concentrate exosomes simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Toward Exosome-Based Neuronal Diagnostic Devices

et al. 2018

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Targeting exosome for liquid biopsy has gained significant attention for its diagnostic and therapeutic potential. For detecting neuronal disease diagnosis such as Alzheimer’s disease (AD), the main technique for identifying AD still relies on positron-emission tomography (PET) imaging to detect the presence of amyloid-β (Aβ). While the detection of Aβ in cerebrospinal fluid has also been suggested as a marker for AD, the lack of quantitative measurements has compromised existing assays. In cerebrospinal fluid, in addition to Aβ, T-Tau, and P-Tau, alpha-synuclein has been considered a biomarker of neurodegeneration. This review suggests that and explains how the exosome can be used as a neuronal diagnostic component. To this end, we summarize current progress in exosome preparation/isolation and quantification techniques and comment on the outlooks for neuronal exosome-based diagnostic techniques.

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“…[19] Other research employed paperbased fluidic devices containing Nafion plugs or membranes. [20][21][22] Devices with a channel containing a Nafion patch resemble those with bipolar electrodes. The high counter ion concentration in the patch leads to a high conductivity, so the patch may carry a significant fraction of the total current in this region.…”

Section: Figurementioning

confidence: 99%

“…Following the simple single‐channel preconcentration with bipolar electrodes, Han and coworkers demonstrated trace analyte accumulation in a single channel containing an ion‐exchange patch (Figure ) . Other research employed paper‐based fluidic devices containing Nafion plugs or membranes . Devices with a channel containing a Nafion patch resemble those with bipolar electrodes.…”

Section: Introductionmentioning

confidence: 99%

Current‐Induced Ion Concentration Polarization at a Perfect Ion‐Exchange Patch in an Infinite Insulating Wall

2020

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This research examines, theoretically, the ion concentration polarization, ion fluxes, and electrostatic fields near an ion‐exchange patch in the wall of an electrified fluidic channel. These phenomena are important in related microfluidic ion‐preconcentration systems. Under an electric field, counter ions enter the ion‐exchange patch at one side and leave at the other, with salt depletion occurring near the entrance and accumulation near the exit. The high patch conductivity and the concentration profiles lead to local electric field perturbations that may facilitate preconcentration. This study includes analytical expressions of ion concentrations and electrochemical potentials at small to moderate electric fields, as well as numerical simulations. Additionally, a simple matrix of polynomial coefficients (obtained via fitting of numerical data) enables analytical calculation of the two‐dimensional concentration profiles at all electric fields within the range investigated in the numerical simulations. This is possible because a single dimensionless parameter controls this problem.

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High-ionic-strength pre-concentration via ion concentration polarization for blood-based biofluids

Cited by 35 publications

References 46 publications

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Toward Exosome-Based Neuronal Diagnostic Devices

Current‐Induced Ion Concentration Polarization at a Perfect Ion‐Exchange Patch in an Infinite Insulating Wall

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