High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics

Heropoulos, Georgios A.; Georgakopoulos, Spyros; Steele, Barry R.

doi:10.1016/j.tetlet.2005.02.038

Cited by 23 publications

(8 citation statements)

References 36 publications

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“…Under such conditions, the most standout influence produced by sonication is possibly the erosion effect that occurs in reaction systems containing solid metals [1,5]. For example, the reduction of 1,2,4,5-tetra(1-ethylpropyl)-3-nitrobenzene Eqn (7.14) takes place almost quantitatively in 15 min under sonication, whereas mechanical stirring gives at a lower yield in 20 h [16]. The elimination of the intermediates generated on the surface of metal also causes the effects.…”

Section: Solideliquid Phase Reactionsmentioning

confidence: 99%

Application of Ultrasound to Organic Synthesis

Kimura

2015

Sonochemistry and the Acoustic Bubble

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Section: Solideliquid Phase Reactionsmentioning

confidence: 99%

Application of Ultrasound to Organic Synthesis

Kimura

2015

Sonochemistry and the Acoustic Bubble

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“…A chemoselective reduction of the nitro group was effected using Fe-AcOH in an ethanol/water mixture which gave 156 in 82 % isolated yield [51][52][53]. Diazonium-ion formation was achieved under typical conditions [48], obtaining salt 140, after precipitation from cold ether/acetone, as a brown fluffy solid in 93 % yield.…”

Section: Regioselectivity In the Intramolecular Heck Reaction Of Sulfmentioning

confidence: 99%

Selectivity in the Synthesis of Cyclic Sulfonamides

Geoghegan¹

2014

Springer Theses

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The series "Springer Theses" brings together a selection of the very best Ph.D. theses from around the world and across the physical sciences. Nominated and endorsed by two recognized specialists, each published volume has been selected for its scientific excellence and the high impact of its contents for the pertinent field of research. For greater accessibility to non-specialists, the published versions include an extended introduction, as well as a foreword by the student's supervisor explaining the special relevance of the work for the field. As a whole, the series will provide a valuable resource both for newcomers to the research fields described, and for other scientists seeking detailed background information on special questions. Finally, it provides an accredited documentation of the valuable contributions made by today's younger generation of scientists.Theses are accepted into the series by invited nomination only and must fulfill all of the following criteria • They must be written in good English.• The topic should fall within the confines of Chemistry, Physics, Earth Sciences, Engineering and related interdisciplinary fields such as Materials, Nanoscience, Chemical Engineering, Complex Systems and Biophysics.

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“…Sono-chemistry is the application of ultrasound technique has undergone very intensive research and development in the last 15-20 years to carry out chemical transformation. Ultrasound offers potential for cleaner reactions called green protocol keeping in mind to protect environment clean and green through improved product yields and selectivity towards desired product, reduce the time of completion of reaction [11][12][13] and enhanced ease of product recovery.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound assisted synthesis of 2, 4-substituted 1, 5- benzothiazepine derivatives

Ghodke

Wagh²,

Nikalje³

et al. 2019

Proceedings of the 23rd International Electronic Conference on Synthetic Organic Chemistry

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A series of 15 novel derivatives of Synthesis of 2, 4-substituted 1, 5-benzothiazepine 5(a-l)were synthesized in good yield from the key compound 1, 3-substituted-prop-2-en-1-one 3(a-l), called chalcone, with 2-aminothiophenol (0.01mol) and pinch of zirconium oxychloride and solvent dimethyl formamide (DMF), by using ultra-sonication as one of the green chemistry tools. The 1,5benzothiazepine scaffold has several biological activity such as vasodilator, antiarrythmic antagonists of several G-protein coupled receptors such as cholecystokinin (CCK) receptor, antiulcer activity, anticonvulsant activity.

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High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics

Cited by 23 publications

References 36 publications

Application of Ultrasound to Organic Synthesis

Application of Ultrasound to Organic Synthesis

Selectivity in the Synthesis of Cyclic Sulfonamides

Ultrasound assisted synthesis of 2, 4-substituted 1, 5- benzothiazepine derivatives

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