Ultrasound assisted synthesis of 2, 4-substituted 1, 5- benzothiazepine derivatives

Abstract

A series of 15 novel derivatives of Synthesis of 2, 4-substituted 1, 5-benzothiazepine 5(a-l)were synthesized in good yield from the key compound 1, 3-substituted-prop-2-en-1-one 3(a-l), called chalcone, with 2-aminothiophenol (0.01mol) and pinch of zirconium oxychloride and solvent dimethyl formamide (DMF), by using ultra-sonication as one of the green chemistry tools. The 1,5benzothiazepine scaffold has several biological activity such as vasodilator, antiarrythmic antagonists of several G-protein coupled receptors such as cholecystokinin (CCK) receptor, antiulcer activity, anticonvulsant activity.