High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes

Maillard, Florie; Rousset, Sylvie; Pereira, Bruno; Traoré, Amidou; Amaze, P. de Pradel del; Boirie‌, Yves; Duclos, Martine; Boisseau, Nathalie

doi:10.1016/j.diabet.2016.07.031

Cited by 116 publications

(130 citation statements)

References 39 publications

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“…This finding is akin to seven of the eight prior HIIT and MICT comparison studies that reported similar improvements in HbA1c for both their intervention groups [(25, 27, 56–60)]. The remaining comparison study Støa et al (61) reported a greater significant change in HbA1c for HIIT, however, the authors did report that the greater effect may have been due to the significantly higher HbA1c level in their HIIT group ( P = 0.02) at baseline.…”

Section: Discussionsupporting

confidence: 66%

High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

et al. 2018

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We sought to determine the efficacy of 12 weeks high-intensity interval training (HIIT), compared to moderate-intensity continuous training (MICT) on glucose control, cardiometabolic risk and microvascular complication markers in men living with type 2 diabetes (T2D). Both modalities were combined with resistance training (RT). Additionally, the study aimed to determine the medium-term durability of effects. After a 12-week, thrice weekly, training intervention incorporating either MICT+RT (n = 11) or HIIT+RT (n = 12), the study concluded with a 6-month follow-up analysis. The middle-aged study participants were obese, had moderate duration T2D and were taking multiple medications including insulin, statins and beta-blockers. Participants, randomized via the method of minimization, performed MICT (progressing to 26-min at 55% maximum estimated workload [eWLmax]) or HIIT (progressing to two variations in which twelve 1-min bouts at 95% eWLmax interspersed with 1-min recovery bouts, alternated with eight 30-s bouts at 120% eWLmax interspersed with 2:15 min recovery bouts) under supervision at an exercise physiology facility. To account for fixed and random effects within the study sample, mixed-effect models were used to determine the significance of change following the intervention and follow-up phases and to evaluate group*time interactions. Beyond improvements in aerobic capacity (P < 0.001) for both groups, both training modalities elicited similar group*time interactions (P > 0.05) while experiencing benefits for glycated hemoglobin (HbA1c; P = 0.01), subcutaneous adiposity (P < 0.001), and heart rate variability (P = 0.02) during the 12-week intervention. Adiposity (P < 0.001) and aerobic capacity (P < 0.001) were significantly maintained in both groups at the 6-month follow-up. In addition, during the intervention, participants in both MICT+RT and HIIT+RT experienced favorable reductions in their medication usage. The study reported the inter-individual variability of change within both groups, the exaggerated acute physiological responses (using exercise termination indicators) that occurred during the interventions as well as the incidence of precautionary respite afforded in such a study sample. To reduce hyperglycaemia, and prevent further deterioration of cardiometabolic risk and microvascular complication markers (in both the short- and medium-term), future strategies that integrate the adoption and maintenance of physical activity as a cornerstone in the treatment of T2M for men should (cognisant of appropriate supervision) include either structured MICT+RT, or HIIT+RT.Clinical Trials Registration Number: ACTRN12617000582358 http://www.anzctr.org.au/default.aspx

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Section: Discussionsupporting

confidence: 66%

High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

et al. 2018

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“…Two studies used the same sample,61 62 and one performed a double-blind, randomised, crossover investigation with seven athletes (five males and two females) 68. The mean age of study participants ranged from 10.464 to 70.1 years 87. The training status of the participants ranged from sedentary73 to high-level athletes 68.…”

Section: Resultsmentioning

confidence: 99%

“…Others used bioelectrical impedance,57 64 65 78 89 91 hydrodensitometry,54 air displacement plethysmography60 83 or skinfold measurements 61 62 66 72 76 90. Three studies used two body composition assessments methods, such as DXA and CT,87 bioelectrical impedance and CT,82 and bioelectrical impedance and MRI 73supplementary table S3 shows additional information about body composition assessment methods used in the included studies.…”

Section: Resultsmentioning

confidence: 99%

Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT)

Viana¹,

Naves²,

Coswig³

et al. 2019

Br J Sports Med

108

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ObjectivesTo compare the effects of interval training and moderate-intensity continuous training (MOD) on body adiposity in humans, and to perform subgroup analyses that consider the type and duration of interval training in different groups.DesignSystematic review and meta-analysis.Data sourcesEnglish-language, Spanish-language and Portuguese-language searches of the electronic databases PubMed and Scopus were conducted from inception to 11 December 2017.Eligibility criteria for selecting studiesStudies that met the following criteria were included: (1) original articles, (2) human trials, (3) minimum exercise training duration of 4 weeks, and (4) directly or indirectly compared interval training with MOD as the primary or secondary aim.ResultsOf the 786 studies found, 41 and 36 were included in the qualitative analysis and meta-analysis, respectively. Within-group analyses showed significant reductions in total body fat percentage (%) (interval training: −1.50 [95% CI −2.14 to −0.86, p<0.00001] and MOD: −1.44 [95% CI −2.00 to −0.89, p<0.00001]) and in total absolute fat mass (kg) (interval training: −1.58 [95% CI −2.74 to −0.43, p=0.007] and MOD: −1.13 [95% CI −2.18 to −0.08, p=0.04]), with no significant differences between interval training and MOD for total body fat percentage reduction (−0.23 [95% CI −1.43 to 0.97], p=0.705). However, there was a significant difference between the groups in total absolute fat mass (kg) reduction (−2.28 [95% CI −4.00 to −0.56], p=0.0094). Subgroup analyses comparing sprint interval training (SIT) with MOD protocols favour SIT for loss of total absolute fat mass (kg) (−3.22 [95% CI −5.71 to −0.73], p=0.01). Supervised training, walking/running/jogging, age (<30 years), study quality and intervention duration (<12 weeks) favourably influence the decreases in total absolute fat mass (kg) observed from interval training programmes; however, no significant effect was found on total body fat percentage (%). No effect of sex or body mass index was observed on total absolute fat mass (kg) or total body fat percentage (%).ConclusionInterval training and MOD both reduce body fat percentage (%). Interval training provided 28.5% greater reductions in total absolute fat mass (kg) than MOD.Trial registration numberCRD42018089427.

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“…Interestingly, reductions in body mass and glycated hemoglobin (HbA1C) following bariatric surgery partially rescued MAIT cell abnormalities and attenuated inflammatory cytokine production (Magalhaes et al 2015). Aerobic exercise training can also reduce total body and fat mass and HbA1C and improve insulin sensitivity (Maillard et al 2016;Willis et al 2012), which may partially alleviate the decrease in MAIT cell numbers. However, body mass and fat changes with exercise training are modest (2-3%), even in overweight and obese adults (Ohkawara et al 2007;Willis et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Maximal exercise increases mucosal associated invariant T cell frequency and number in healthy young men

et al. 2017

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Methods Twenty healthy young males with moderate fitness levels performed an extended graded exercise test until volitional fatigue. Peripheral blood mononuclear cells were isolated from venous blood obtained prior and immediately after exercise and were labeled to identify specific T cell populations using flow cytometry. Results The percentage of MAIT cells relative to total T cells significantly increased from 3.0 to 3.8% and absolute MAIT cell counts increased by 2.2-fold following maximal exercise. MAIT cell subpopulation proportions were unchanged with exercise. Within cytotoxic T lymphocytes (CTL), MAIT cells consisted of 8% of these cells and this remained constant after exercise. MAIT cell counts and changes with exercise were not affected by body composition, VO 2peak , or exercise duration. Conclusions Maximal exercise doubled MAIT cell numbers and showed preferential mobilization within total T cells but the response was not influenced by fitness levels, exercise duration, or body composition. These results suggest that acute exercise could be used to offset MAIT cell deficiencies observed with certain pathologies. MAIT cells also make up a substantial proportion of CTLs, which may have implications for cytotoxicity assays using these cells. Keywords TCR Vα7.2 · Exercise immunology · MAIT cells

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High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes

Cited by 116 publications

References 39 publications

High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT)

Maximal exercise increases mucosal associated invariant T cell frequency and number in healthy young men

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