High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation

Abstract

Regular high-intensity interval exercise training was associated with a significant reduction in late luminal loss in the stented coronary segment. This effect was associated with increased aerobic capacity, improved endothelium function, and attenuated inflammation.

High-Intensity Intermittent Exercise Training for Cardiovascular Disease

“…Currier et al [50] observed similar training effect in relative VO 2peak with no differences between low-volume high-intensity interval exercises training versus endurance training. However, they highlight that the increase in VO 2peak (24%) observed after high-intensity exercise training was larger than the changes observed in previous HIIE investigations [28,49,51]. Also, Warburton et al [29] found similar increase in VO 2peak and time to exhaustion after 16 weeks of high-intensity interval training compared to moderate training in CAD patients.…”

“…Endothelial function with different exercise intensities training has been tested in CAD patients [49][50][51]55]. Increased brachial artery flowmediated dilation was observed after 6 months of supervised highintensity interval exercise training in coronary artery disease patients [51].…”

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

“…65,210 Some protocols also call for a functional or anatomic test (eg, treadmill test, rest scintigraphy, coronary CT angiography, stress imaging). Coronary CT angiography is associated with rapid assessment, high negative predictive value, decreased length of stay, and reduced costs [205][206][207] ; however, in the latter studies, it increased the rate of invasive coronary angiography and revascularization with uncertain long-term benefits in low-risk patients without ECG or troponin alterations. 211 Accelerated diagnostic protocols are also potentially applicable in intermediate-risk patients, whose presentation includes a history of cardiovascular disease, diabetes mellitus, chronic kidney disease (CKD), and/or advanced age.…”

Oral Rapamycin to Reduce Intimal Hyperplasia After Bare Metal Stent Implantation - A Prospective Randomized Intravascular Ultrasound Study

“…The oral approach has been so far reported in small size studies. The studies suggest that a course of 30 days of oral therapy is both safe an effective and that efficacy is tied to serum blood levels of the drug (Brara et al, 2003;Cernigliaro et al, 2010;Chaves et al, 2005;Fox et al, 2009;Gallo et al, 1999;Guarda et al, 2004;Hausleiter et al, 2004;Munk et al, 2009;Rodriguez et al, 2003;Rodriguez et al, 2005;Rodriguez et al, 2006;Rodriguez, 2009;Rodriguez et al, 2009;Jennings & Kalus 2010;Stojkovic et al, 2010;Waksman et al, 2004;Waksman et al, 2006). Future investigation into the efficacy of oral antiproliferative agents also during the periprocedural period of BMS or DES implantation is still needed.…”

“…Patients enrolled into the high-intesitive training group also demonstrated a significantly lower cardiac event rate. The hypothesis surrounding the potential benefit of a high intensity exercise training is that such activity may be beneficial in minimizing endothelial dysfunction after stent implantation (Munk et al, 2009). …”