High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial

Abstract

HIT represents a promising strategy to improve verbal memory and physical fitness in persons with MS. Further research is needed to determine the impact of exercise on biomarkers in MS.

Short-term aerobic training does not improve memory functioning in relapsing remitting multiple sclerosis – a randomized controlled trial

“…But is verbal learning and memory the neurocognitive domain most sensitive to exercise interventions? Consistent with our earlier study in progressive MS, a recent trial on high intensity training could show effects on different cognitive dimensions with strongest effects in the verbal memory dimension of the BICAMS (Zimmer et al 2017). However, in the few other MS exercise studies most effects were reported in information processing speed and executive functioning (Sandroff et al 2016).…”

“…Specifically, the study did not show effects on any cognitive measure and failed to produce significant changes in any of the obtained patient related or objective outcome measures for functioning in MS. These results thus cast doubt on the generalizability of recent trials that suggested the potential of exercise to improve cognitive function in progressive (Briken et al 2014) or relapsing-remitting MS (Zimmer et al 2017).…”

“…Studies in ageing healthy adults performed training in up to 52 weeks and meta-analytic data indicate a relevant effect of intervention length (Northey et al 2017). Intriguingly, the recent study by Zimmer indicated that high intensity training over just 3 weeks can have beneficial effects on cognition as well other functional domains (Zimmer et al 2017). Therefore, an optimal balance of intensity and duration needs to be achieved and weighted against other factors such as treatment adherence and attrition.…”

Plasma brain-derived neurotrophic factor (BDNF) and sphingosine-1-phosphat (S1P) are NOT the main mediators of neuroprotection induced by resistance training in persons with multiple sclerosis—A randomized controlled trial

“…In addition, sphingosine-1-phosphat (S1P) -a sphingolipid metabolite known to modulate the CNS directly (Hla and Brinkmann, 2011;Soliven et al, 2011) or indirectly by facilitating BDNF expression (Fukumoto et al, 2014;Smith et al, 2018) -may also be involved in mediating exercise-induced neuroprotective effects in pwMS. Indeed, AT alone (Bansi et al, 2013;Briken et al, 2016;Castellano and White, 2008;Gold et al, 2003) or combined with pilates (Ozkul et al, 2018) or RT (Wens et al, 2016) can lead to acute and chronic increases in circulating BDNF levels in pwMS, although negative findings also exist (Bansi et al, 2013;Briken et al, 2016;Schulz et al, 2004;Zimmer et al, 2017). While little is known about circulating S1P levels in pwMS, AT has been shown to increase acute (Baranowski et al, 2015;Baranowski et al, 2011) and chronic circulating S1P levels in healthy young individuals (Ksiazek et al, 2018).…”

The Effect of Three Different Strategies Based on Motor Task Performance on Neuromuscular Fatigue in Healthy Men and Men with Multiple Sclerosis

“…Exercise can be a helpful rehabilitation approach for individuals with MS to reestablish function, endorse wellness, and increase involvement in activities of daily living [11,12,13]. Moreover, accumulating evidence suggests that persons with MS are less physically active than are non-diseased populations [12].…”