Plasma brain-derived neurotrophic factor (BDNF) and sphingosine-1-phosphat (S1P) are NOT the main mediators of neuroprotection induced by resistance training in persons with multiple sclerosis—A randomized controlled trial

Jørgensen, M.L.K.; Kjølhede, Tue; Dalgas, Ulrik; Hvid, Lars G.

doi:10.1016/j.msard.2019.03.029

Cited by 16 publications

(50 citation statements)

References 52 publications

(107 reference statements)

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“…1. Eighteen studies (34.6%) involved only aerobic exercises [5,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45], 16 studies (30.8%) involved only resistance exercise [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61], and 18 studies (34.6%) involved a combination of aerobic and resistance exercise [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77]…”

Section: Resultsmentioning

confidence: 99%

“…1 . Eighteen studies (34.6%) involved only aerobic exercises [ 5 , 29 – 45 ], 16 studies (30.8%) involved only resistance exercise [ 46 – 61 ], and 18 studies (34.6%) involved a combination of aerobic and resistance exercise [ 62 – 79 ]. Of these, ten studies were multi-armed trials that evaluated different rates of aerobic and resistance exercise [ 75 ], various aerobic exercise protocols [ 5 , 79 ] or different community exercise interventions [ 67 ], or compared aerobic and/or resistance exercise to an ineligible intervention arm (such as yoga) [ 29 , 38 , 40 , 48 , 49 , 54 , 67 ].…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

et al. 2021

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Introduction: The objective of this systematic review is to explore the application and reporting of (i) the principles of exercise training in exercise trials, (ii) the components of exercise prescription, and (iii) the adherence towards the prescribed programmes in randomised controlled trials (RCTs) in persons with multiple sclerosis (pwMS). Methods:The MEDLINE, CINAHL, SPORTDiscus, PubMed and Embase electronic databases were searched from 1 January 2000 to 16 October 2020. RCTs comprising at least 3 weeks of aerobic and/or resistance exercise intervention in pwMS that reported at least one physiological outcome and were published in peerreviewed journals were eligible for inclusion. Results: Out of 52 RCTs included in this review, 58 intervention arms were examined. None applied more than four principles of exercise training. Specificity was addressed by 85%, progression by 33%, overload by 59%, initial values by 26%, reversibility by 0% and diminishing returns by 2% of trials. Fifty-two percent of trials reported all components of exercise prescription, and 3% of trials reported the level of adherence to the prescribed exercise. Marit L. Schlagheck and Niklas Joisten contributed equally and share first authorship. Annette Rademacher and Philipp Zimmer contributed equally and share last authorship.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

et al. 2021

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“…In particular, an increase in BDNF, which may improve dementia risk factors through enhanced functional fitness, is reported to reduce B-amyloid frequently found in the brain of Alzheimer's patients [47]. Jørgensen et al [48] reported no significant improvement in BDNF although it has shown an enhancement in muscle strength as a result of resistance exercise while Marinus et al [49] reported that combining muscle exercise and aerobic exercise is effective in increasing the effects of BDNF. Taekwondo training is believed to enhance muscle strengths as well as cognitive function thanks to the successive moves of both hands and feet at the same time by remembering the basic movements and aerobic/anaerobic poomsae [40].…”

Section: Discussionmentioning

confidence: 99%

Effects of Functional Fitness Enhancement through Taekwondo Training on Physical Characteristics and Risk Factors of Dementia in Elderly Women with Depression

Baek

Hong

Min

et al. 2021

IJERPH

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The purpose of this research is to identify the correlations between functional fitness enhancement through a long-term Taekwondo training program and the physical characteristics and risk factors of dementia among elderly women with depression. The study has found that conducting three 60-min Taekwondo training sessions a week for the duration of 12 weeks has enhanced a number of functional fitness indexes, including hand grip strength/weight (p < 0.01), 4-m gait speed (p < 0.001), 3-m timed up and go (p < 0.05), and figure-of-eight track (p < 0.05), and significantly improved general health condition indexes as well, including percent fat (p < 0.05), appendicular skeletal muscle mass index (p < 0.01), systolic blood pressure (p < 0.01), and diastolic blood pressure (p < 0.001). Furthermore, the arteriosclerosis index and cognitive function have been found to be improved with an increase of brain-derived neurotrophic factor (BDNF; which prevents dementia) and a significant decrease of β-amyloid—a risk factor of dementia—as a result of enhancements in serum lipids and adiponectin, confirming the positive effects of functional fitness enhancement on fighting depression, promoting physical characteristics, and reducing the risk factors of dementia.

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“…The effect of resistance training on plasma S1P concentration remains unclear. Jorgensen et al 44 found no change in S1P level in patients with multiple sclerosis subjected to 24 weeks of high‐intensity resistance training. On the other hand, plasma S1P concentration was markedly increased in rats following 8 weeks of training on a resistance ladder 41…”

Section: Effect Of Training On S1p Metabolismmentioning

confidence: 97%

Sphingosine‐1‐phosphate in acute exercise and training

Hodun

Chabowski

Baranowski

2021

Scandinavian Med Sci Sports

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Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid found in all eukaryotic cells. Although it may function as an intracellular second messenger, most of its effects are induced extracellularly via activation of a family of five specific membrane receptors. Sphingosine‐1‐phosphate is enriched in plasma, where it is transported by high‐density lipoprotein and albumin, as well as in erythrocytes and platelets which store and release large amounts of this sphingolipid. Sphingosine‐1‐phosphate regulates a host of cellular processes such as growth, proliferation, differentiation, migration, and apoptosis suppression. It was also shown to play an important role in skeletal muscle physiology and pathophysiology. In recent years, S1P metabolism in both muscle and blood was found to be modulated by exercise. In this review, we summarize the current knowledge on the effect of acute exercise and training on S1P metabolism, highlighting the role of this sphingolipid in skeletal muscle adaptation to physical effort.

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Plasma brain-derived neurotrophic factor (BDNF) and sphingosine-1-phosphat (S1P) are NOT the main mediators of neuroprotection induced by resistance training in persons with multiple sclerosis—A randomized controlled trial

Cited by 16 publications

References 52 publications

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

Effects of Functional Fitness Enhancement through Taekwondo Training on Physical Characteristics and Risk Factors of Dementia in Elderly Women with Depression

Sphingosine‐1‐phosphate in acute exercise and training

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