High intensity interval exercise decreases IL-8 and enhances the immunomodulatory cytokine interleukin-10 in lean and overweight–obese individuals

Dorneles, Gilson Pires; Haddad, Desirée O.; Fagundes, Viviane O.; Vargas, Bruna K.; Kloecker, Alana; Romão, Pedro R T; Peres, Alessandra

doi:10.1016/j.cyto.2015.10.003

Cited by 116 publications

(121 citation statements)

References 46 publications

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“…Furthermore, Wadley et al (2016) compared untrained males who undertook three exercise bouts: HIIE (10 × 1-min at 90% VO 2max ) and two energy-matched steady-state cycling bouts at a moderate (60% VO 2max , 27 min) and high (80% VO 2max , 20 min) intensity, and showed that IL-6 and IL-10 increased after 30 min in both HIIE and high intensity steady-state cycling, demonstrating similar inflammatory and oxidative stress responses. Taken together, these studies showed that the acute anti-inflammatory response in HIIE seems to be intensity-dependent (Cabral-Santos et al, 2015; Dorneles et al, 2016). However, our results contradict, at the least, this perspective showing that also the duration of an exercise bout may be an important variable.…”

Section: Discussionmentioning

confidence: 92%

“…Lira et al (2015) submitted athletes to 4 sessions of the Wingate test at 100% of VO 2peak and observed an increase in IL-10 levels, inducing beneficial alterations in the resting inflammatory profile. Dorneles et al (2016) demonstrated that 10 × 60 s at 85–90% of maximal aerobic power, separated by 75-s at 50% of maximal aerobic power (which gives a mean workload of 65.6–67.8% of P max ), was able to induce a progressive elevation of IL-6 and IL-10 levels immediately and 30-min post exercise in both lean and overweight-obese subjects. These results suggest an important implication of this exercise in the control of chronic low-grade inflammation in obesity.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Cabral-Santos¹,

Castrillón²,

Miranda³

et al. 2016

Front. Physiol.

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The purpose of this study was to compare the effects of two similar high-intensity intermittent exercises (HIIE) but different volume 1.25 km (HIIE1.25) and 2.5 km (HIIE2.5) on inflammatory and BDNF responses. Ten physically active male subjects (age 25.22 ± 1.74 years, body mass 78.98 ± 7.31 kg, height 1.78 ± 0.06 m, VO2peak 59.94 ± 9.38 ml·kg·min−1) performed an incremental treadmill exercise test and randomly completed two sessions of HIIE on a treadmill (1:1 min at vVO2max with passive recovery). Blood samples were collected at rest, immediately and 60-min after the exercise sessions. Serum was analyzed for glucose, lactate, IL-6, IL-10, and BDNF levels. Blood lactate concentrations was higher immediately post-exercise compared to rest (HIIE1.25: 1.69 ± 0.26–7.78 ± 2.09 mmol·L−1, and HIIE2.5: 1.89 ± 0.26–7.38 ± 2.57 mmol·L−1, p < 0.0001). Glucose concentrations did not present changes under the different conditions, however, levels were higher 60-min post-exercise than at rest only in the HIIE1.25 condition (rest: 76.80 ± 11.14–97.84 ± 24.87 mg·dL−1, p < 0.05). BDNF level increased immediately after exercise in both protocols (HIIE1.25: 9.71 ± 306–17.86 ± 8.59 ng.mL−1, and HIIE2.5: 11.83 ± 5.82–22.84 ± 10.30 ng.mL−1). Although both exercises increased IL-6, level percent between rest and immediately after exercise was higher in the HIIE2.5 than HIIE1.25 (30 and 10%; p = 0.014, respectively). Moreover, IL-10 levels percent increase between immediately and 60-min post-exercise was higher in HIIE2.5 than HIIE1.25 (37 and 10%; p = 0.012, respectively). In conclusion, both HIIE protocols with the same intensity were effective to increase BDNF and IL-6 levels immediately after exercise while only IL-10 response was related to the durantion of exercise indicanting the importance of this exercise prescription variable.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Cabral-Santos¹,

Castrillón²,

Miranda³

et al. 2016

Front. Physiol.

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“…However, it remains unclear what the inflammatory response is in the absence of weight loss and what the consequences of this might be [47]. Acute exercise is associated with both an immune cell redistribution and an inflammatory response which following exercise cessation returns to normal levels between 0.5 and 24 hours [48–50]. …”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Robinson and colleagues also found no significant effects of HIIT or MICT on systemic inflammation [20]. A number of recent studies have highlighted the acute inflammatory response to HIIT and its similarity to MICT; however, these snapshots do not inform of longitudinal responses [50, 52]. As inflammatory biomarkers are used more in prediction of disease outcomes, future research should aim to determine the discrete and analogous effects of intervention-specific weight and fitness responses on inflammation.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

Bartlett

Shepherd

Wilson

et al. 2017

Oxidative Medicine and Cellular Longevity

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Neutrophils and monocytes are key components of the innate immune system that undergo age-associated declines in function. This study compared the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on immune function in sedentary adults. Twenty-seven (43 ± 11 years) healthy sedentary adults were randomized into ten weeks of either a HIIT (>90% maximum heart rate) or MICT (70% maximum heart rate) group training program. Aerobic capacity (VO2peak), neutrophil and monocyte bacterial phagocytosis and oxidative burst, cell surface receptor expression, and systemic inflammation were measured before and after the training. Total exercise time commitment was 57% less for HIIT compared to that for MICT while both significantly improved VO2peak similarly. Neutrophil phagocytosis and oxidative burst and monocyte phagocytosis and percentage of monocytes producing an oxidative burst were improved by training similarly in both groups. Expression of monocyte but not neutrophil CD16, TLR2, and TLR4 was reduced by training similarly in both groups. No differences in systemic inflammation were observed for training; however, leptin was reduced in the MICT group only. With similar immune-enhancing effects for HIIT compared to those for MICT at 50% of the time commitment, our results support HIIT as a time efficient exercise option to improve neutrophil and monocyte function.

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“…In our study the levels of IL-17 increased, albeit not significantly, in the AS group. In healthy male subjects, physical activity such as high and mild-to-moderate training have not been shown to influence serum IL-17a [60], but another study in duathlon athletes suggests a potential role of the IL-17 axis in muscle damage after prolonged training [61]. On the other hand, women with multiple sclerosis were found to have lower levels of systemic IL-17 and a lower inflammatory status after an 8-week exercise programme [62].…”

Section: Discussionmentioning

confidence: 99%

Clinical improvement and reduction in serum calprotectin levels after an intensive exercise programme for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis

et al. 2016

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BackgroundThe efficacy of exercise therapy for ankylosing spondylitis (AS) is well-documented, but dearth of information is for non-radiographic axial spondyloarthritis (nr-axSpA).Biomarkers like serum calprotectin, interleukins IL-6, IL-17 and tumour necrosis factor (TNF)-α may reflect the disease activity of axial spondyloarthritis (axSpA). In this study, we investigated clinical and laboratory parameters of both axSpA subgroups in response to intensive physical exercise.MethodsAltogether, 46 patients with axSpA, characterised according to the Assessment of SpondyloArthritis International Society criteria as having nr-axSpA or AS underwent 6-month exercise programme. Clinical outcomes of disease activity, Bath AS Disease Activity Index (BASDAI), AS Disease Activity Index (ASDAS-CRP), mobility, Bath AS Metrology Index (BASMI) and function, Bath AS Functional Index (BASFI) were evaluated at baseline and at the end of the exercise programme. Serum IL-6 and IL-17, TNF-α and calprotectin were measured via ELISA. The clinical and laboratory data of 29 control axSpA patients were used for the evaluation of the results.ResultsIn all axSpA patients, the ASDAS-CRP (2.10 ± 0.12 to 1.84 ± 0.11, p <0.01) and BASMI (1.28 ± 0.14 to 0.66 ± 0.84, p <0.0001) improved after 6 months of exercise therapy. There was a significant improvement in the ASDAS-CRP in the nr-axSpA subgroup (2.01 ± 0.19 to 1.73 ± 0.16, p <0.05) and in the BASMI in both, the nr-axSpA and the AS subgroups (1.09 ± 0.12 to 0.47 ± 0.08, p <0.0001 and 1.43 ± 0.24 to 0.82 ± 0.23, p <0.0001, respectively). Both, ASDAS-CRP and BASDAI, were significantly improved in the exercise axSpA group compared to the control axSpA group (mean -0.26 vs. -0.13 and -0.49 vs. 0.12, respectively, all p <0.05). Only calprotectin was significantly reduced after the exercise programme in nr-axSpA and AS patients (from 2379.0 ± 243.20 to 1779.0 ± 138.30 μg/mL and from 2430.0 ± 269.70 to 1816.0 ± 148.20 μg/mL, respectively, all p <0.01). The change in calprotectin was more profound in the axSpA intervention group (mean -604.56) than in the control axSpA (mean -149.28, p <0.05).ConclusionThis study demonstrated similar efficacy for an intensive exercise programme in both nr-axSpA and AS patients. A significant decrease in serum calprotectin levels in both subgroups of axSpA patients after the exercise programme reflected an improvement in the disease activity and spinal mobility.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-016-1180-1) contains supplementary material, which is available to authorized users.

show abstract

High intensity interval exercise decreases IL-8 and enhances the immunomodulatory cytokine interleukin-10 in lean and overweight–obese individuals

Cited by 116 publications

References 46 publications

Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

Clinical improvement and reduction in serum calprotectin levels after an intensive exercise programme for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis

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