2016
DOI: 10.1186/s13075-016-1180-1
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Clinical improvement and reduction in serum calprotectin levels after an intensive exercise programme for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis

Abstract: BackgroundThe efficacy of exercise therapy for ankylosing spondylitis (AS) is well-documented, but dearth of information is for non-radiographic axial spondyloarthritis (nr-axSpA).Biomarkers like serum calprotectin, interleukins IL-6, IL-17 and tumour necrosis factor (TNF)-α may reflect the disease activity of axial spondyloarthritis (axSpA). In this study, we investigated clinical and laboratory parameters of both axSpA subgroups in response to intensive physical exercise.MethodsAltogether, 46 patients with a… Show more

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Cited by 41 publications
(29 citation statements)
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References 53 publications
(75 reference statements)
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“…This concept of "energetic concurrency" between physical activity and immunity is postulated to account for the reductions in inflammation that occur with exercise. Of note, CP levels will decrease after a six-month physical exercise program in adults with rheumatological conditions [22]. To our knowledge, it is not known whether physical activity levels will inversely correlate with CP levels in otherwise healthy people, especially healthy children.…”
Section: Discussionmentioning
confidence: 91%
“…This concept of "energetic concurrency" between physical activity and immunity is postulated to account for the reductions in inflammation that occur with exercise. Of note, CP levels will decrease after a six-month physical exercise program in adults with rheumatological conditions [22]. To our knowledge, it is not known whether physical activity levels will inversely correlate with CP levels in otherwise healthy people, especially healthy children.…”
Section: Discussionmentioning
confidence: 91%
“…In this study, that included a large cohort of patients with axSpA, we disclosed significantly lower CPT serum concentrations in our patients when compared to controls. In this regard, a recent study revealed that CPT levels decrease after the end of a 6-month intensive exercise programme in AS and nr-axSpA patients, accompanied by clinical improvement 45 . This may be particularly relevant, given that regular exercise and physical therapy is recommended to complement medical therapy in axSpA, aimed to ameliorate physical disability as well as cardiorespiratory complications of the disease 46 .…”
Section: Discussionmentioning
confidence: 99%
“…With supervised group exercise (SGE), greater improvements in quality of life, spinal mobility, and patient global assessment were achieved as compared to unsupervised, individual exercise programs . SGE appears similarly effective for patients with radiographic axial SpA (also known as ankylosing spondylitis) and those with nonradiographic axial SpA . Recently, results of a systematic review on the effectiveness of exercise either on land or in water in patients with radiographic axial SpA demonstrated the added value of hydrotherapy and education within SGE (including 35 trials) .
Recent scientific insight on supervised group exercise (SGE) for patients with axial spondyloarthritis (SpA) recommend appropriately dosed strengthening and cardiorespiratory exercise (in addition to mobility exercise), monitoring of intensity of cardiorespiratory exercise, periodic reassessments, patient education, and guidance by therapists who specialize in axial SpA, yet these aspects may currently be missing in practice. The majority of patients with axial SpA who participated in weekly SGE were satisfied with its current contents and mode of delivery. The majority of patients with axial SpA would agree with the introduction of program enhancements; however, given the high current satisfaction, a planned and tailored implementation strategy (including education) is warranted.
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Section: Introductionmentioning
confidence: 99%