High-intensity focused ultrasound in ovarian cancer xenografts

Wu, Rong; Hu, Bing; Jiang, Lixin; Hung, Ying Cho; Kuang, Sheng‐Li; Zhang, Bulin

doi:10.1007/s12325-008-0084-0

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…20 However, gene delivery with plasmid vectors is highly inefficient unless the plasmid DNA is administered with other molecules or physical methods. 21 Ultrasound is a familiar technique in the clinic and is well known to patients; 22 Sonoporation is now considered as the key mechanism of UMMD and has previously been used to efficiently deliver plasmid DNA to cells. 12 The aim of our study was to attempt to elu- Further studies are needed to evaluate the therapeutic value of this promising approach.…”

Section: Immunohistochemical Findingsmentioning

confidence: 99%

Induced apoptosis with ultrasound-mediated microbubble destruction and shRNA targeting survivin in transplanted tumors

et al. 2008

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Section: Immunohistochemical Findingsmentioning

confidence: 99%

Induced apoptosis with ultrasound-mediated microbubble destruction and shRNA targeting survivin in transplanted tumors

et al. 2008

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“…Tumour volume was measured by transcutaneous ultrasound, and the long and short dimensions of the tumour were measured transcutaneously using a vernier calliper. As nude mice have thin skin, no hair and little subcutaneous fat, no correction for skin thickness was made (10,11). Tumour volume was calculated based on the assumption that each tumour was a regular ellipsoid.…”

Section: Methodsmentioning

confidence: 99%

Treatment of pancreatic cancer in a nude mouse model using high-intensity focused ultrasound

Jiang¹,

Hu²,

Guo³

et al. 2012

Experimental and Therapeutic Medicine

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The purpose of this study was to determine whether high-intensity focused ultrasound (HIFU) is an effective treatment for pancreatic cancer in an athymic nude mouse model. Female athymic nude mice (n=44) were inoculated subcutaneously with 5–7×106 SW1990 human pancreatic cancer cells. Thirty-six animals developed tumours and were randomly divided into three groups: HIFU (n=18), sham treatment (n=9) and control (n=9). The sonographic appearance of the tumours during therapy was recorded. After therapy, the tumours were examined transcutaneously by ultrasound every 4 days for 4 weeks. Tissue samples were taken from the treatment sites and histopathologically examined by light or electron microscopy. Two weeks after HIFU treatment, a 100% reduction in tumour volume was observed in all animals in the HIFU group, whereas tumours in the sham-treated and control groups continued to grow. Pathological examination of HIFU-treated tumour tissue samples showed complete coagulation necrosis in the tumour. Our results indicate that HIFU appears to be an effective therapy for pancreatic tumours in an athymic nude mouse model. Thus, the treatment may hold promise for the clinical treatment of late-stage and recurrent pancreatic cancer.

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“…ume of gynecological cancers, such as uterine leiomyosarcoma [10] and ovarian carcinoma [11]. The animal models that have been used for the investigation of HIFU for the treatment of obstetric disease can be divided into those designed to study vascular occlusion and those suitable for tissue volume ablation, in pregnant or non-pregnant animals.…”

Section: Hifu In Pre-clinical Studies !mentioning

confidence: 99%

High-Intensity Focused Ultrasound in Obstetrics and Gynecology: The Birth of a New Era of Noninvasive Surgery?

et al. 2012

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Although ultrasound is an essential investigative modality in obstetrics and gynecology, the potential for therapeutic high-intensity focused ultrasound (HIFU) (also referred to as focused ultrasound surgery, FUS) to offer an alternative to invasive surgery is less well known. The ability of HIFU to create discrete regions of tissue necrosis only in precisely targeted positions by careful placement of the focus, without the need for any surgical intervention, has made HIFU of interest to those seeking noninvasive alternatives to conventional abdominal surgery. This article reviews the current experimental and clinical experience with HIFU in obstetrics and gynecology, and outlines potential future applications in fetal medicine and the challenges faced in their development.

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High-intensity focused ultrasound in ovarian cancer xenografts

Abstract: Our results indicate that HIFU appears to be an effective therapy for ovarian carcinoma tumours in the athymic nude mouse model. We suggest that it may hold promise for the clinical treatment of late-stage and recurrent ovarian cancer.

Cited by 5 publications

References 14 publications

Induced apoptosis with ultrasound-mediated microbubble destruction and shRNA targeting survivin in transplanted tumors

Induced apoptosis with ultrasound-mediated microbubble destruction and shRNA targeting survivin in transplanted tumors

Treatment of pancreatic cancer in a nude mouse model using high-intensity focused ultrasound

High-Intensity Focused Ultrasound in Obstetrics and Gynecology: The Birth of a New Era of Noninvasive Surgery?

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