High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy

Mitra, Devarati; Horick, Nora; Brackett, Diane; Mouw, Kent W.; Hornick, Jason L.; Ferrone, Soldano; Hong, Theodore S.; Mamon, Harvey J.; Clark, Jeffrey W.; Parikh, Aparna R.; Allen, Jill N.; Ryan, David P.; Ting, David T.; Wo, Jennifer Y.

doi:10.1634/theoncologist.2018-0794

Cited by 21 publications

(16 citation statements)

References 42 publications

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“…High IDO expression, like NOS2 and COX2, predicts poor outcome [90,[96][97][98]. Given that IDO is a heme protein, it is susceptible to redox regulation.…”

Section: Tryptophan and N-formylkynureninementioning

confidence: 99%

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

McGinity

Palmieri

Somasundaram

et al. 2021

IJMS

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The metabolic requirements and functions of cancer and normal tissues are vastly different. Due to the rapid growth of cancer cells in the tumor microenvironment, distorted vasculature is commonly observed, which creates harsh environments that require rigorous and constantly evolving cellular adaption. A common hallmark of aggressive and therapeutically resistant tumors is hypoxia and hypoxia-induced stress markers. However, recent studies have identified alterations in a wide spectrum of metabolic pathways that dictate tumor behavior and response to therapy. Accordingly, it is becoming clear that metabolic processes are not uniform throughout the tumor microenvironment. Metabolic processes differ and are cell type specific where various factors promote metabolic heterogeneity within the tumor microenvironment. Furthermore, within the tumor, these metabolically distinct cell types can organize to form cellular neighborhoods that serve to establish a pro-tumor milieu in which distant and spatially distinct cellular neighborhoods can communicate via signaling metabolites from stroma, immune and tumor cells. In this review, we will discuss how biochemical interactions of various metabolic pathways influence cancer and immune microenvironments, as well as associated mechanisms that lead to good or poor clinical outcomes.

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“…High IDO expression, like NOS2 and COX2, predicts poor outcome [90,[96][97][98]. Given that IDO is a heme protein, it is susceptible to redox regulation.…”

Section: Tryptophan and N-formylkynureninementioning

confidence: 99%

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

McGinity

Palmieri

Somasundaram

et al. 2021

IJMS

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“…IDO1 is interferon-induced and has been shown to mediate powerful immunosuppression in cancer. Growing evidence indicates that IDO1 is overexpressed in the vast majority of solid tumors and associated with clinical prognosis, such as anal ( 18 ), esophageal ( 19 ), as well as cervical cancer ( 20 ). More importantly, several molecular drugs targeting IDO1 have been evaluated in multiple clinical trials with encouraging results ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

Tumor-Infiltrating CD8+ T Cells Driven by the Immune Checkpoint-Associated Gene IDO1 Are Associated With Cervical Cancer Prognosis

et al. 2021

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Tumor-infiltrating immune cells, associated with tumor progression, are promising prognostic biomarkers. However, the relationship between levels of gene expression and that of immune cell infiltration in cervical cancer prognosis is unknown. In this study, three cervical cancer gene expression microarrays (GSE6791, GSE63678 and GSE55940) were obtained from the GEO database. The IDO1 gene was identified by differentially expressed gene screening. The gene expression profiles of TCGA and GTEx databases along with comprehensive bioinformatics analysis identified that the IDO1 gene was upregulated in cervical cancer with significant difference in expression at different N stages. In addition, it was also upregulated in HPV16 positive sample. The pan-cancer analysis identified that IDO1 was highly expressed in most cancers. TIMER analysis revealed that the expression of IDO1 in CESC shows positive correlation with CD8+ T cells, CD4+ T cells, neutrophils, dendritic cells. IDO1 expression showed remarkable positive correlation with all immune cell markers except M1 macrophages. CD8+ T cell infiltration GSEA results showed that IDO1 was mainly associated with tumor immune-related signaling pathways.

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“…A study in the United States revealed that advanced T stage and immune marker e.g. tumour indoleamine 2,3 dioxygenase 1 (IDO 1) could be used as predictor of recurrence [25].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and prognosis of anal squamous cell carcinoma: a retrospective audit of 144 patients from 11 cancer hospitals in southern China

Wang

Zhang

et al. 2020

BMC Cancer

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Background: The incidence of anal squamous cell carcinoma (SCC) has been steadily growing globally in the past decade. Clinical data on anal SCC from China are rare. We conducted this study to describe the clinical and epidemiological characteristics of anal SCC in China and explore prognostic factors of outcomes among patients with anal SCC. Methods: We audited demographic characteristics, relevant symptoms, risk factors, treatment modalities and outcomes for patients diagnosed with anal SCC at 11 medical institutions in China between January 2007 and July 2018. Results: A total of 144 patients (109 females) were diagnosed with SCC during this period. Median age at initial diagnosis was 52.0 (interquartile range: 46.0-61.8) years. The most common symptoms were bleeding (n = 93, 64.6%), noticing a lump (n = 49, 34.0%), and pain (n = 47, 32.6%). The proportion of patients at the American Joint Committee on Cancer (AJCC) stages I-IV were 10 (6.9%), 22 (15.3%), 61 (42.4%) and 8 (5.6%), respectively, and AJCC stages in 43 (29.9%) patients were unknown. Thirty-six patients (25.0%) underwent abdominoperineal resection initially. Univariable analysis showed that T stage predicted recurrence-free survival (RFS) (Hazard ratio [HR] = 3.03, 95% Confidence interval [CI]: 1.10-8.37, p = 0.032), and age group (HR = 2.90, 95% CI: 1.12-7.49, p = 0.028), AJCC stage (HR = 4.56, 95% CI: 1.02-20.35, p = 0.046), and N stage (HR = 3.05, 95% CI: 1.07-8.74, p = 0.038) predicted overall survival (OS).

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High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy

Cited by 21 publications

References 42 publications

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

Tumor-Infiltrating CD8+ T Cells Driven by the Immune Checkpoint-Associated Gene IDO1 Are Associated With Cervical Cancer Prognosis

Clinical characteristics and prognosis of anal squamous cell carcinoma: a retrospective audit of 144 patients from 11 cancer hospitals in southern China

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