High homocysteine and low folate plasma concentrations are associated with cardiovascular events but not bleeding during warfarin treatment

Lind, Marcus; Jansson, Jan‐Håkan; Nilsson, Torbjörn; Johansson, Lars

doi:10.1515/cclm-2016-0092

Cited by 6 publications

(3 citation statements)

References 28 publications

(22 reference statements)

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“…Hcy can modulate periodontal diseases by increasing acute‐phase reactant proteins in the circulation, through IL‐6, TNF‐α and/or regulated and normal t‐cell expressed and secreted (RANTES) release from the inflamed tissues (Polepalle, Moogala, Boggarapu, Pesala, & Palagi, 2015; Sun, Wang, Zhang, Zeng, & Wang, 2005). Hcy levels elevate in case of vitamin B 12 or FA deficiency (Dillon et al, 2010; Lind, Jansson, Nilsson, & Johansson, 2016). Wang et al (2005) showed positive contribution of low‐dose FA on hyperhomocysteinaemia by inhibiting chemokine secretion from monocytes.…”

Section: Discussionmentioning

confidence: 99%

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

Keçeli

Ercan

Hendek

et al. 2020

J Clinic Periodontology

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Aim: To evaluate clinical and biochemical effects of adjunctive systemic folic acid (FA) intake with scaling and root planing (SRP) in periodontitis treatment. Materials and methods: Sixty periodontitis subjects (30 per group) were randomly assigned into study groups and treated with either SRP + placebo (SRP + P) or SRP + folic acid (SRP + F). In addition to clinical parameters (plaque index [PI], gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL] and gingival recession [GR]), gingival crevicular fluid (GCF) samples were obtained at baseline and post-treatment (PT) periods (one (PT-1), three (PT-3) and six (PT-6) months) for C-reactive protein (CRP) and homocysteine (Hcy) evaluation.Results: Significant time-dependent reduction was detected at all clinical parameters for both groups (p < .001). Compared to SRP + P, CAL was lower in SRP + F at PT-1 (p = .004) and PT-3 (p = .035), whereas GR was lower at only PT-1 (p = .015). GCF volume and CRP did not show inter-group differences, whereas Hcy was higher in SRP + F at PT-3 (p = .044) and PT-6 (p = .041). GCF volume and Hcy showed reduction after treatment in both groups (p < .001). Conclusion: Both modalities exhibited clinical improvement and change in biochemical parameters. Adjunctive systemic FA intake may be recommended adjunctive to periodontitis treatment to reveal better outcomes. However, its impact mechanisms should be further enlightened. K E Y W O R D S C-reactive protein, folic acid, gingival crevicular fluid, homocysteine, periodontal treatment, periodontitis | 603 KECELI Et aL.

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Section: Discussionmentioning

confidence: 99%

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

Keçeli

Ercan

Hendek

et al. 2020

J Clinic Periodontology

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“…The previous studies also showed a similar reduction in folate levels under FD treatment [32][33][34][35] . Importantly, low folate levels have been linked with the risk for certain tumors 36 .…”

Section: Discussionmentioning

confidence: 99%

Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells

Sharma

Ali

Kaur

2022

Sci Rep

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Folate ingestion below and above the physiologic dose has been shown to play a tumorigenic role in certain cancers. Also, excessive folate supplementation after establishment of pre-established lesions led to an advancement in the growth of a few tumors. However, such information has not yet been achieved in the case of HCC. In our study, HepG2 cells were administered with three different concentrations of folic acid i.e. folic acid normal (FN) (2.27 µM), folic acid deficient (FD) (no folic acid), folic acid oversupplementation (FO) (100 µM) for 10 days. Intracellular folate levels were assayed by Elecsys Folate III kit based method. The migratory and invasive abilities were estimated by transwell migration and matrigel invasion methods respectively. FACS was done to evaluate cell viability and apoptosis. Agarose-coated plates were used to access cancer stem cells (CSCs) number. Quantitative RT-PCR and western blotting approaches were used for gene and protein expression of certain tumor suppressor genes (TSGs), respectively. FD cells depicted increased migration, invasion, apoptosis, necrosis and decreased cell viability, CSCs. On the other hand, FO cells showed increased migration, invasion, cell viability and number of CSCs and decreased apoptosis and necrosis. TSGs revealed diminished expression with both FA modulations with respect to FN cells. Thus, FA deficiency as well as abundance enhanced the HCC progression by adapting different mechanisms.

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“…No association of serum folate levels with bleeding. In a longitudinal cohort human study on 719 patients taking long-term warfarin, high homocysteine levels (≥17.2 µmol/L) and serum folate (≥11.9 nmol/L) were not associated with bleeding events, but both were associated with cardiovascular events (myocardial infarction, ischemic stroke, peripheral arterial emboli) [288] (Table 2).…”

Section: Folate (B9)mentioning

confidence: 99%

Potential Drug–Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin—A Review of the Literature

Renaud,

Höller,

Michel

2024

Nutrients

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In cardiology, acetylsalicylic acid (ASA) and warfarin are among the most commonly used prophylactic therapies against thromboembolic events. Drug–drug interactions are generally well-known. Less known are the drug–nutrient interactions (DNIs), impeding drug absorption and altering micronutritional status. ASA and warfarin might influence the micronutritional status of patients through different mechanisms such as binding or modification of binding properties of ligands, absorption, transport, cellular use or concentration, or excretion. Our article reviews the drug–nutrient interactions that alter micronutritional status. Some of these mechanisms could be investigated with the aim to potentiate the drug effects. DNIs are seen occasionally in ASA and warfarin and could be managed through simple strategies such as risk stratification of DNIs on an individual patient basis; micronutritional status assessment as part of the medical history; extensive use of the drug–interaction probability scale to reference little-known interactions, and application of a personal, predictive, and preventive medical model using omics.

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High homocysteine and low folate plasma concentrations are associated with cardiovascular events but not bleeding during warfarin treatment

Abstract: In patients receiving warfarin treatment, high homocysteine and low folate plasma concentrations are associated with increased risk for cardiovascular events but not major bleeding. For homocysteine levels, there is also an association with all-cause mortality.

Cited by 6 publications

References 28 publications

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C‐reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo‐controlled clinical trial

Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells

Potential Drug–Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin—A Review of the Literature

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