High HbA1c level was the most important factor associated with prevalence of diabetic retinopathy in Taiwanese type II diabetic patients with a fixed duration

Sheu, Shwu‐Jiuan; Liu, Ni-Chun; Ger, Lu‐Ping; Ho, Wan‐Ling; Lin, Jiun-Yo; Chen, Shih-Chou; Horng, Yu-Harn; Lam, Hing‐Chung

doi:10.1007/s00417-013-2310-y

Cited by 17 publications

(21 citation statements)

References 28 publications

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“…For the gender factors, Lopez et al (2017) determined that retinopathy in women are more common related to retinopathy in elderly patients with T2DM. 23 Another retrospective study also found that women were more likely to have retinopathy than men 24 , the results of which matched the results of this study. The estrogen production could regulate ocular blood flow to protect the retina; and its antioxidant effects were the primary protective effect on the lens.…”

Section: Discussionsupporting

confidence: 86%

“…Therefore, the prevalence of DR in patients would rise substantially when the patient's diabetic durations were over 10 years. 27 Some studies also found that the longer duration of diabetes, the higher chance of retinopathy appeared; with impact on the risk of DR. 17,24,28 The result of those studies were corresponding to our study. Therefore, well controlled earlier could prevent and delay the progression of DR in patients with diabetes.…”

Section: Discussionsupporting

confidence: 83%

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The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

Chiu

Tsai

et al. 2020

Preprint

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KEYWORDS health behavior; chewing betel nut; dilated fundus examination 2 Abstract Background: Diabetic retinopathy (DR) caused by small vessel disease was the main cause of blindness in person with diabetes, and it mainly occurred in patients with Type 2 diabetes mellitus (T2DM). Taiwan was one of the Asian countries with the highest prevalence rate of DR, there were only few studies for the risk of DR in patients with T2DM in Taiwan. According to some studies have shown DR was a major cause of blindness on elderly both in developed and other developing countries. The purpose was to investigate the related risk factors of DR in elderly patients with T2DM. Methods: During July 2010 to December 2017, 4010 T2DM patients without DR were preselected for this study, but 792 patients completed the continuously follow-up evaluation. Patients were invited to have an outpatient visit at least every three months, and they were asked to fill out a brief questionnaire and collect their blood samples. Additionally, statistical methods used independent sample T-test, Chi-square tests and logistic regression in univariate analysis to analyze the relationships between onset DR and each related factor; and finally the optimal multivariate logistic regression model would be determined by stepwise model selection. Results: Of the 792 effective samples, 611 patients (77.1%) progressed to DR and 181 patients

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 83%

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

Chiu

Tsai

et al. 2020

Preprint

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“… 32 Atorvastatin is an effective and safe treatment for hyperlipidemia in Taiwanese diabetic patients. 33 In the present study, we found that adjuvant treatment with atorvastatin was associated with a significant decrease in serum levels of TC, TG, and LDL levels as well as serum hs-CRP levels. Hs-CRP was a cardiovascular risk predictor in type 2 diabetics with normal lipid profile.…”

Section: Discussionsupporting

confidence: 59%

Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes

et al. 2015

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Impact of atorvastatin on carotid intima-media thickness (CIMT) in patients with type 2 diabetes is still debating.The aim of our study is to investigate atorvastatin as adjuvant treatment on CIMT in Chinese patients with type 2 diabetes by conducting a meta-analysis based on the randomized controlled trials (RCTs).A systematic search of electronic database of the Pubmed, EMBASE, Cochrane Library, VIP database, China National Knowledge Infrastructure, and Wangfang up to January 2015 was conducted. Randomized controlled trials (RCTs) comparing atorvastatin adjuvant treatment to the hypoglycemic therapies or high-dose atorvastatin versus low-dose atorvastatin therapies for patients with type 2 diabetes were selected.A total of 14 RCTs involving 1345 patients were included. Adjuvant treatment with atorvastatin was associated with a significant reduction in CIMT (weighted mean difference [WMD] = −0.17 mm; 95% confidence interval [CI] −0.22 to −0.12). Compared with the low-dose atorvastatin, high-dose atorvastatin treatment was associated with a significant reduction in CIMT (WMD = −0.17 mm; 95% CI: −0.32 to −0.02). Adjuvant treatment with atorvastatin reduced serum total cholesterol, triglyceride, low-density lipoproteins, and high sensitivity C-reactive protein levels. However, atorvastatin had no significant impact on blood glucose levels.This meta-analysis demonstrated that treatment with atorvastatin significantly reduced CIMT in Chinese patients with type 2 diabetes. Moreover, high-dose atorvastatin appeared to have additional benefits in reducing CIMT than the low-dose atorvastatin.

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“…3,[29][30][31] Our study shows that presence of diabetic retinopathy is higher in patients with high levels of HbA1c, a finding similar to a study done previously in Taiwan. 32 Our study had the limitations of a relatively small number of patients and the accuracy of DR grading based on clinical diagnosis, compared with grading based on seven field stereo fundus photography. The latter limitation may be compensated for by the fact that all examinations were conducted by the same group of medical personnel in one medical centre.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of dry eyes syndrome and retinopathy in diabetic patients and the association of glycosylated hemoglobin with retinopathy

Sijapati¹,

Basnet²,

Basnet³

2018

J Pathol Nep

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Background: Diabetes is one of the most common leading causes of blindness in 20–74 year old persons. Recently, problems involving the ocular surface, dry eyes in particular, have been reported in diabetic patients. This study was performed to assess the prevalence of dry eyes syndrome and diabetic retinopathy and its association with HbA1c in diabetic patients.Materials and Methods: All the diabetic patients referred to Eye OPD were consecutively selected during the study period of three years. All the subjects were assessed by developed questionnaire; complete eye examination and Tear Film break up time (TBUT) test and Schirmer’s test. HbA1c was performed in all patients as advised by the physician and was entered in our records.Results: Of 304 subjects, 165 patients (54.3%) suffered from dry eyes syndrome. Although dry eyes syndrome was more common in female patients, this association was not significant. Diabetic Retinopathy was found in 154 patients (50.65%). Dry eyes syndrome was more frequent in diabetic patients with diabetic retinopathy. (P = 0.02). Compared with patients without diabetic retinopathy, those with diabetic retinopathy were more likely to have higher HbA1c (p<0.001). Conclusion: Diabetic retinopathy and dry eyes appear to have a common association like ageing. Examination for dry eyes should be an integral part of the assessment of diabetic eye disease. In addition, high HbA1c level was an important factor associated with prevalence of Diabetic Retinopathy.

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High HbA1c level was the most important factor associated with prevalence of diabetic retinopathy in Taiwanese type II diabetic patients with a fixed duration

Abstract: High HbA1c level was the most important factor associated with prevalence of DR in Taiwanese type II DM patients with a fixed duration.

Cited by 17 publications

References 28 publications

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

The related risk factors of diabetic retinopathy in elderly patients with Type 2 diabetes mellitus: A cohort study

Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes

Prevalence of dry eyes syndrome and retinopathy in diabetic patients and the association of glycosylated hemoglobin with retinopathy

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