High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes

Nomani, Ali Zohair; Nabi, Sumaira; Ahmed, Sibtain; Iqbal, Muhammad Omer; Rajput, Haris Majid; Rao, S.N. Chenna Kesava

doi:10.1136/svn-2016-000018

Cited by 16 publications

(12 citation statements)

References 20 publications

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“…The mean age ± SD in present study was 60.86 ± 12.51 years compared to study done by Vaidya C et al [10] and Maskey A et al [11] where it was 61 and 63 year respectively. The major age group was >70 year followed by 61-70 years compared to study done by Vaidya C et al [10] and similar study by Ukoha OB et al [12] Mean age ± SD in diabetic group was 59.25 ± 11.13 years compared to 55.6 years in study done by Nomani AZ et al [13] Mean age ± SD was 62.03 ± 13.30 years in nondiabetic group compared to study done by Nomani AZ et al [13] The major age group in diabetic group was 51-60 compared to >70 years in non-diabetic group. In this study age was found to be an important factor for ischemic stroke similar to what was concluded from Helsinki Young Stroke Registry which finds the frequency of ischemic stroke rises sharply beginning at the age of 40.…”

Section: Age Wise Distribution Of Stroke Patientsmentioning

confidence: 58%

“…The Atherosclerosis Risk in Communities (ARIC) Study [22] found that in diabetic group patients the adjusted risk of stroke was 2.33 (95% CI 1.29-4.21) in highest percentile of HbA1c (>6.8%) as compared with the lowest one (<4.7%), Nomani AZ et al [13] mean HbA1c values were significantly higher in the diabetes group (7.6 ± 2.1 vs 6.1 ± 2.3) (p<0.05).…”

Section: Hba1c and Duration Of Diabetesmentioning

confidence: 99%

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Clinicodemographic Profile and Risk Factors of Stroke in Diabetic and Nondiabetic Patients in Vindhya Region

Baghel¹,

Singh²,

Dandotiya³

2019

jemds

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BACKGROUND Stroke is defined as abrupt onset of neurologic deficit that is attributable to a focal vascular cause. It represents the second most common cause of mortality and the third most common cause of disability in developed countries. Diabetes is an important risk factor for ischemic stroke and the risk of ischemic stroke in patients with diabetes is twice as in those without diabetes. Hence the need of a study to assess the pattern of stroke, clinical profile and risk factors in diabetes mellitus and nondiabetic patients. MATERIALS AND METHODS This was a cross sectional study conducted on 500 patients of stroke for a duration of one year. Written informed consent was taken from all patients. History, clinical examination and radiological investigations (CT Scan/ MRI) was done for confirmation of stroke. Haematological and biochemical examination (HbA1c and Lipid profile) were done. ECG was done to rule out CAD. RESULTS Out of 500 patients, 72.8% had ischemic stroke and 27.2% had haemorrhagic stroke. Diabetic patients had greater probability of ischemic stroke (81.73%). Stroke was more common in males with a male to female ratio of 1.52:1. (60.4% vs 39.6%). Young stroke (≤45 year) comprised of 12.8% patients. 52.4% patients were hypertensive. In diabetic group, hypertension was present in 60.09% and in nondiabetics 46.91%, and this was significant (p value-0.00046). Diabetic hypertensives have significant association with ischemic stroke. 86.5% of the diabetic patients had HbA1c >6.5 % reflecting poor glycemic control. 99.3% patients in nondiabetic group had HbA1c<6.5 %. HbA1c is positively associated with ischemic stroke (p-value was <0.05). CONCLUSION This study shows that diabetes mellitus increases the risk of ischemic stroke. Diabetic stroke patients were younger as compared to nondiabetic stroke patients. Hypertension, poor glycemic control, dyslipidemia, obesity, smoking and tobacco chewing increases the risk of ischemic stroke. Thus, we can use glycemic control, HbA1c and duration of diabetes as a predictor of stroke

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Section: Age Wise Distribution Of Stroke Patientsmentioning

confidence: 58%

Section: Hba1c and Duration Of Diabetesmentioning

confidence: 99%

Clinicodemographic Profile and Risk Factors of Stroke in Diabetic and Nondiabetic Patients in Vindhya Region

Baghel¹,

Singh²,

Dandotiya³

2019

jemds

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“…Higher HbA1C levels correlated with a higher clinical risk, even in nondiabetic patients. An increased risk of ischemic stroke has been reported when HbA1c levels exceed 5.6% 15,16) . A meta-analysis including 36 observational cohort and nested case-control cohort studies showed a 49% increase in the risk of first-ever ischemic stroke for every 1% increase in the HbA1c level in non-diabetic cohorts 17) , suggesting that maintaining lower HbA1c levels protects patients from adverse CV events.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin A1C Levels are Independently Associated with the Risk of Coronary Atherosclerotic Plaques in Patients without Diabetes: A Cross-Sectional Study

Wang

Hsu

Lin

et al. 2020

JAT

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The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Original Article Aim: Coronary atherosclerotic plaques can be detected in asymptomatic subjects and are related to low-density lipoprotein cholesterol (LDL) levels in patients with coronary artery disease. However, researchers have not yet determined the associations between various plaque characteristics and other lipid parameters, such as HDL-C and TG levels, in low-risk populations. Methods: One thousand sixty-four non-diabetic subjects (age, 57.86 9.73 years; 752 males) who underwent coronary computed tomography angiography (CCTA) were enrolled and the severity and patterns of atherosclerotic plaques were analyzed. Results: Statin use was reported by 25% of the study population, and subjects with greater coronary plaque involvement (segment involvement score, SIS) were older and had a higher body mass index (BMI), blood pressure, unfavorable lipid profiles and comorbidities. After adjusting for comorbidities, only age (0.085, p 0.001), the male gender (1.384, p 0.001), BMI (0.055, p 0.019) and HbA1C levels (0.894, p 0.001) were independent factors predicting the greater coronary plaque involvement in non-diabetic subjects. In the analysis of significantly different (50%) stenosis plaque patterns, age (OR: 1.082, 95% CI: 10.47-1.118) and a former smoking status (OR: 2.061, 95% CI: 1.013-4.193) were independently associated with calcified plaques. For partial calcified (mixed type) plaques, only age (OR: 1.085, 95% CI: 1.052-1.119), the male gender (OR: 7.082, 95% CI: 2.638-19.018), HbA1C levels (OR: 2.074, 95% CI: 1.036-4.151), and current smoking status (OR: 1.848, 95% CI: 1.089-3.138) were independently associated with the risk of the presence of significant stenosis in mixed plaques. Conclusions: A higher HbA1c levels is independently associated with the presence and severity of coronary artery atherosclerosis in non-diabetic subjects, even when LDL-C levels are tightly controlled. causes of an increased risk in mortality and morbidity, and the central component of the pathogenesis is atherosclerosis. Atherosclerosis is currently considered a

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“…In particular, women were reported to have more aphasia, dysphagia and visual field disorders than men, while no differences were reported for motor and sensory deficits. [5][6][7][8] From the demographic data obtained hemorrhagic stroke patients with an average age of 52.19±14.12 years whereas in ischemic stroke patients the mean age was 52.71±10.88 years, according to Bushnell et al that stroke patients female sex live longer, and risk Lifelong strokes at the age of 55-75 years are higher in women than men. 9 From the demographic data in this study obtained ischemic stroke patients and acute hemorrhagic stroke with a level of education that is more high school, where in the study of Samal et al, which states the role of education is needed to reduce the occurrence of risk factors for stroke by 40%.…”

Section: Discussionmentioning

confidence: 99%

Correlation of blood glucose levels, HbA1c, hemoglobin and leukocytes with outcome on acute stroke

2019

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Background: Diabetes and higher HbA1c level have increased the incidence of stroke. Hemoglobin levels both high and low are associated with poor outcomes. Leukocytes play an important role in the initiation of the atherosclerosis process.Methods: This was a cross-sectional study with a sample size of 62 people selected by non-random sampling method on a consecutive basis, patients with acute stroke were taken blood to measure blood glucose levels, HbA1c, Hb and Leucocytes when entering the hospital room. Outcomes were assessed using NIHSS and MRS. The calculation of NIHSS and MRS scores was performed on the first day of admission and the fourteenth day. To analyze the correlation of blood sugar levels during HbA1c, Hb and leukocytes in acute stroke, this study used Spearman's correlation test. The p value <0.05 was considered statistically significant.Results: The study subjects of 62 acute stroke patients (acute ischemic stroke 31 people and 31 people hemorrhagic stroke). Acute stroke patients were consisted of 38 men (61.3%) and 24 women (38.7%). Of 31 people with hemorrhagic stroke, there were 16 men (51.6%) and 15 women (48.4%), ischemic stroke patients were consisted of 22 people (71, 0%) and women were 9 people. Spearrman repair test showed no symptoms between blood glucose levels, HbA1c, Hemoglobin and leukocytes with outcomes in acute stroke.Conclusions: There was no significant association between blood glucose levels, HbA1c, hemoglobin and leukocytes with outcomes in acute stroke.

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High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes

Cited by 16 publications

References 20 publications

Clinicodemographic Profile and Risk Factors of Stroke in Diabetic and Nondiabetic Patients in Vindhya Region

Clinicodemographic Profile and Risk Factors of Stroke in Diabetic and Nondiabetic Patients in Vindhya Region

Hemoglobin A1C Levels are Independently Associated with the Risk of Coronary Atherosclerotic Plaques in Patients without Diabetes: A Cross-Sectional Study

Correlation of blood glucose levels, HbA1c, hemoglobin and leukocytes with outcome on acute stroke

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