Hemoglobin A1C Levels are Independently Associated with the Risk of Coronary Atherosclerotic Plaques in Patients without Diabetes: A Cross-Sectional Study

Abstract

The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Original Article Aim: Coronary atherosclerotic plaques can be detected in asymptomatic subjects and are related to low-density lipoprotein cholesterol (LDL) levels in patients with coronary artery disease. However, researchers have not yet determined the associations between various plaque characteristics and other lipid parameters, such as HDL-C and TG levels, in low-risk populations. Methods: One thousand sixty-four non-diabetic subjects (age, 57.86 9.73 years; 752 males) who underwent coronary computed tomography angiography (CCTA) were enrolled and the severity and patterns of atherosclerotic plaques were analyzed. Results: Statin use was reported by 25% of the study population, and subjects with greater coronary plaque involvement (segment involvement score, SIS) were older and had a higher body mass index (BMI), blood pressure, unfavorable lipid profiles and comorbidities. After adjusting for comorbidities, only age (0.085, p 0.001), the male gender (1.384, p 0.001), BMI (0.055, p 0.019) and HbA1C levels (0.894, p 0.001) were independent factors predicting the greater coronary plaque involvement in non-diabetic subjects. In the analysis of significantly different (50%) stenosis plaque patterns, age (OR: 1.082, 95% CI: 10.47-1.118) and a former smoking status (OR: 2.061, 95% CI: 1.013-4.193) were independently associated with calcified plaques. For partial calcified (mixed type) plaques, only age (OR: 1.085, 95% CI: 1.052-1.119), the male gender (OR: 7.082, 95% CI: 2.638-19.018), HbA1C levels (OR: 2.074, 95% CI: 1.036-4.151), and current smoking status (OR: 1.848, 95% CI: 1.089-3.138) were independently associated with the risk of the presence of significant stenosis in mixed plaques. Conclusions: A higher HbA1c levels is independently associated with the presence and severity of coronary artery atherosclerosis in non-diabetic subjects, even when LDL-C levels are tightly controlled. causes of an increased risk in mortality and morbidity, and the central component of the pathogenesis is atherosclerosis. Atherosclerosis is currently considered a

Prolonged sitting time links to subclinical atherosclerosis

“…Plaque with >50% stenosis was identified as significant plaque according to a previous study investigating the risk ratio of variable plaque patterns in coronary artery. 28,30 A multivariate logistic regression analysis was performed to determine the risk of the presence of significant plaques for every 1-hour increase in sitting time per day. In model 1, the crude odds ratio (OR) was determined.…”

“…The extent scores of all 16 individual segments were summed to yield a total score, which has a range from 0 to 48. 26,27 To investigate the association between daily sitting time and coronary plaque characteristics, we also analyzed the association between sitting time groups and the presence of significant (>50% stenosis) stenotic coronary plaque patterns including calcified, noncalcified and mixed-type plaques as in previous studies 11,28 (Fig. 1).…”

Association between Coronary Artery Plaque Progression and Liver Fibrosis Biomarkers in Population with Low Calcium Scores

“…As shown in the PESA (Progression of Early Subclinical Atherosclerosis) study, subclinical atherosclerosis (plaque or coronary artery calcification) was detected in 49.7% of subjects without a cardiovascular risk factor, and a search for a predictor associated with plaque and plaque progression is crucial in CAD prevention [ 22 , 23 ]. It is assumed that the progression of vascular atherosclerosis is associated with multiple traditional risk factors, such as age, gender, hypertension, DM, dyslipidemia, cigarette smoking, and obesity [ 24 ].…”

Lifestyle intervention using mobile technology and smart devices in patients with high cardiovascular risk: A pragmatic randomised clinical trial

“…HbA1c, which is known as a marker for long-term treatment efficiency in diabetic patients, is independently associated with the presence and severity of atherosclerosis in non-diabetic patients [20]. We enrolled both diabetic and non-diabetic individuals with high CVD risk and evaluated serum HbA1c levels due to its predictive role in CVD occurrence and prognosis.…”