High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

Alotaibi, Sarah; Alotaibi, Faiza; Zaher, Yaseer Al; Zaher, Nabil Al; Dababo, Mohammed

doi:10.1155/2017/7296467

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…7 A rapid progression of ACC could suggest a dedifferentiation, or high-grade transformation of this tumor. 7,8 Contrary to the well-differentiated type, ACC transformation to high grade is associated with a lower survival rate and a higher rate of distant metastases. 7,8 The FDG PET/CT would be of great help to determine the primitive tumor and to look for metastases.…”

Section: Discussionmentioning

confidence: 99%

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Soft tissue metastasis revealing a case of acinar cell carcinoma of unknown primary origin

Ines

Belaid

Mestiri

et al. 2020

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

“…7,8 Contrary to the well-differentiated type, ACC transformation to high grade is associated with a lower survival rate and a higher rate of distant metastases. 7,8 The FDG PET/CT would be of great help to determine the primitive tumor and to look for metastases. However, it has not been made due to its unavailability.…”

Section: Discussionmentioning

confidence: 99%

Soft tissue metastasis revealing a case of acinar cell carcinoma of unknown primary origin

Ines

Belaid

Mestiri

et al. 2020

Clinical Case Reports

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“…No molecular features are described as typical for ACC. High-grade transformation is a rare variant of ACC, anchoring an aggressive clinical behaviour and outcome [17]. Strong membrane beta-catenin and nuclear cyclin D1 immunoreactions have been associated with aggressive high-grade ACCs [16].…”

Section: Discussionmentioning

confidence: 99%

Ectopic Cushing’s Syndrome Unveiling a Metastatic Parotid Carcinoma

Oliveira

Souteiro

Belo

et al. 2019

Case Reports in Endocrinology

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Introduction Adrenocorticotropic hormone (ACTH) ectopic production is a rare cause of Cushing syndrome (CS). The most commonly associated tumours are small-cell lung carcinoma along with bronchial and thymic carcinoids. To date, only 5 cases have been published in the literature featuring ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland. We hereby describe a very uncommon case of ectopic CS (ECS) unveiling a metastatic parotid ACC. Case Presentation A 46-year-old man with hypertension and dyslipidemia diagnosed 4-months before, as well as new-onset diabetes mellitus unveiled 1-month earlier, was referred to emergency department for hypokalemia. Hormonal study and dynamic biochemical tests performed indicated ECS. Imaging and cytological findings pointed toward a likely primary right parotid malignancy with liver metastases. Somatostatin receptor scintigraphy has shown an increased uptake in the parotid gland and mild expression in liver metastasis. The patient underwent right parotidectomy, and histopathologic examination confirmed ACC. Meanwhile, hypercortisolism was managed with metyrapone, ketoconazole, and lanreotide. Despite chemotherapy onset, a rapid disease progression and clinical course deterioration was observed. Conclusion The present report highlights a rare ECS, exposing a metastatic parotid ACC, with an aggressive and challenging clinical course, representing the first case whose diagnosis of ECS came prior to ACC.

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“…Acinar cells are polygonal with lightly basophilic cytoplasm and diastase resistant periodic acid-Schiff (PAS-D) positive zymogen granules. The growth pattern may be predominantly solid, microcystic, papillary-cystic, or follicular (1)(2)(3)(4)(5)(6). Radiation exposure and familial predisposition are possible risk factors for ACC (4,7).…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature

Mirzaian¹,

Asgari-Karchekani²,

Abdoli³

2022

Iran J Pathol

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Scan to discover onlineAcinic cell carcinoma (ACC) is a low or intermediate-grade malignant epithelial neoplasm of the salivary glands that generally shows an indolent behavior. Most cases arise in the major salivary glands, especially the parotid gland. ACC is usually known as a low-grade malignant tumor; however, poorly differentiated and high-grade transformed variants have been reported and may tend to be late recurrence and metastasis.Our case was a 49-year-old woman with a history of a right parotid rapidly growing mass lesion, which was cytologically diagnosed as monomorphic adenoma on fineneedle aspiration (FNA). Finally, the diagnosis of ACC with dedifferentiated components was reported, followed by parotidectomy. After 30 sessions of radiotherapy, she presented with hemifacial paresis. An imaging examination of the brain showed intracranial hemorrhage, and she underwent a craniotomy. We performed histopathological and immunohistochemical (IHC) examinations and diagnosed metastatic ACC with dedifferentiated components.Few ACC cases with dedifferentiated components and with aggressive behavior have been reported in the literature , and to the best of our knowledge, this article is the first English report in Iranian population.

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High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

Cited by 8 publications

References 26 publications

Soft tissue metastasis revealing a case of acinar cell carcinoma of unknown primary origin

Soft tissue metastasis revealing a case of acinar cell carcinoma of unknown primary origin

Ectopic Cushing’s Syndrome Unveiling a Metastatic Parotid Carcinoma

A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature

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