A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature

Mirzaian, Elham; Asgari-Karchekani, Shafigheh; Abdoli, Ashkan

doi:10.30699/ijp.2021.530574.2645

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Primary ACC of the breast has good behavior in most reported cases, despite metastases in axillary lymph nodes that have been reported in five cases [ 26 , 42 , 46 , 48 ]. About 12% of all ACCs develop metastatic disease [ 49 ]. A poor prognosis of ACC has been reported, especially with a high grade of lymph node metastases [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Acinic Cell Carcinoma of the Breast: A Case Report and Review of Literature

Atta

2024

Cureus

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Acinic cell carcinoma (ACC) is an exceedingly rare type of triple-negative breast cancer (TNBC). We are reporting a case of a 46-year-old female patient who presented with a palpable lump in her left breast not associated with pain, pruritis, or change of skin color. An open biopsy revealed a mass of about 20 x 25 mm of fleshy, white tan with a lobular configuration and necrosis. The histopathological examination revealed cells with cytoplasmic granularity arranged in a microglandular pattern and a solid pattern, and the case was initially reported as ACC. The most remarkable feature was the presence of small and large, brightly eosinophilic cytoplasmic granules, and some cells are clear or multivacuolated, resembling lipoblasts. Cellular pleomorphism and anaplasia are very mild, and the mitotic activity was very low. The tumor showed a scant and vascularized stroma in the area of hyalinization. Small clusters of lymphoid infiltration in the stroma were seen. Histochemical stains revealed that the acinar cells in ACC contain abundant diastase-resistant, periodic acid Schiff (PAS)-positive cytoplasmic granules. Mucicarmine and Alcian blue were negative. The immunohistochemistry workup revealed that the case was positive for discovered on gastrointestinal stromal tumors-1 (DOG-1) and the positivity pattern ranged from apical membranous, cytoplasmic, and complete membranous. In addition, the tumor cells were positive for low-molecular-weight cytokeratin, carcinoembryonic antigen (CEA), and epithelial membrane antigen (EMA). The FISH workup for the ETV6-NTRK3 fusion was negative, arguing against secretory carcinoma (SC). A diagnosis of acinar cell carcinoma of the breast is very rare, and the presence of cytoplasmic granules is helpful for its diagnosis. In the absence of these granules, the diagnosis is very difficult, and other diagnoses will be put in the differential diagnosis, particularly SC, lactating adenosis, and microglandular adenosis. Immunohistochemical and histochemical stains and genetic workups will support the diagnosis of ACC.

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Section: Discussionmentioning

confidence: 99%

Acinic Cell Carcinoma of the Breast: A Case Report and Review of Literature

Atta

2024

Cureus

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“…It is due to its aggressive behaviour and distant metastasis. Around 12 % of all acinic cell carcinoma develop metastatic disease, primarily via the hematogenous route [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Chaotic transformation of parotid acinic cell carcinoma to metastatic dedifferentiated high-grade pathology - A rare case with clinical and emotional challenge

Ahmed,

Khan,

Dawood

et al. 2023

International Journal of Surgery Case Reports

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Rare Presentation of Acinic Cell Carcinoma in the Parotid Gland

Yadav,

Agarwal,

Sagar

et al. 2024

Annals of African Medicine

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Acinic cell carcinoma (ACC) arising in the salivary glands is a rare tumor. It is a low-grade malignant salivary gland tumor. It is predominantly seen in females and occurs in the fifth and sixth decades of life. It is mostly located in the parotid gland. ACC has a significant potential for recurrence and metastasis. Therefore, long-term follow-up is necessary after treatment. Here, a 28-year-old male presented with right preauricular swelling for 9 months. Ultrasound of the head-and-neck region and fine-needle aspiration cytology of preauricular swelling suggest the diagnosis of neoplasm in the parotid gland, most probably a benign tumor. After that, a total parotidectomy with facial nerve preservation was performed. On histopathological and immunohistochemical study was consistent with the diagnosis of ACC in the parotid gland.

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A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature

Cited by 3 publications

References 36 publications

Acinic Cell Carcinoma of the Breast: A Case Report and Review of Literature

Acinic Cell Carcinoma of the Breast: A Case Report and Review of Literature

Chaotic transformation of parotid acinic cell carcinoma to metastatic dedifferentiated high-grade pathology - A rare case with clinical and emotional challenge

Rare Presentation of Acinic Cell Carcinoma in the Parotid Gland

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