High-Grade Canine T-cell Lymphoma/Leukemia with Plasmacytoid Morphology: A Clinical Pathological Study of Nine Cases

Ponce, Frédérique; Magnol, J. P.; Marchal, Thierry; Chabanne, Luc; Ledieu, D.; Bonnefont, Cécile; Felman, Pascale; Fournel‐Fleury, C.

doi:10.1177/104063870301500405

Cited by 32 publications

(42 citation statements)

References 21 publications

(45 reference statements)

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“…The results of our study, as well as the results of other authors (Carter et al 1986, Fournel-Fleury et al 1997b, Ponce et al 2003 indicate that, similarly to human NHL (Weiss et al 1987, Schwartz et al 1989, Katz et al 1993, within each histological subtype of canine lymphoma, particular cases have different proliferation potential, and examined indices for different types of lymphoma often reach similar values. The studies in human NHL have shown that the percentage of cells in active phases of the cell cycle both in low-grade as well as high-grade tumors and in given cases of lymphoma of the same morphological subtype, has prognostic significance in respect to survival (Grogan et al 1988, Hall et al 1988, Joensuu et al 1988, Grieson et al 1990, and tumor progression (Schwartz et al 1989, Macartney et al 1991.…”

Section: Discussionsupporting

confidence: 76%

“…A few other authors that distinguished this morphological type of canine lymphoma, pointed its extremely high proliferation potential (Fournel-Fleury et al 2002, Ponce et al 2003. Ponce et al (2003) found very high MI, much more higher than MI values observed in our research (7.5-11.8 vs. 6.60-6.90 respectively) in all investigated cases of such lymphoma, however Ki67 expression in this subtype of lymphoma seems to be lower in Ponce et al study (2003) (50-66% Ki67 + cells in 4 cases and >70% Ki67 + cells only in 2 cases) than in our research. In human medicine LBL is considered as a tumor of high proliferation activity (Mioduszewska 1998, Brunning et al 2001).…”

Section: Discussionmentioning

confidence: 99%

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Proliferation activity in canine lymphomas

Sokołowska¹,

Micun²,

Malicka³

et al. 2012

Polish Journal of Veterinary Sciences

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Forty five lymphomas, 14 of T cell origin, 28 of B cell and 3 with null-cell phenotype, were included in this study. Tumors were classified according to the updated Kiel classification system adapted to canine lymphomas. 3.33). Moreover, high positive correlation between the expression of Ki67 and MI was found (r = 0.668; P ≤ 0.001). In T-cell tumors the correlation was very high (r = 0.83; P ≤ 0.001) and in B-cell lymphomas the correlation was high (r = 0.61; P ≤ 0.001). There were also differences between mean MI values in the lymphomas of different morphological subtypes, but in some of them high variations in the range of MI values were identified and wide overlaps of MI between individual cases from different subtypes were observed. Because of differences in the proliferation activity in single cases of the same subtype of lymphoma, the proliferation activity assessment may be helpful to chose appropriate scheme of treatment and should be commonly performed during routine histopathological diagnosis of canine lymphomas.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Proliferation activity in canine lymphomas

Sokołowska¹,

Micun²,

Malicka³

et al. 2012

Polish Journal of Veterinary Sciences

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“…Paraffin wax-embedded tumor tissues were subsequently sent to Laboratoire de Pathologie Clinique et Unité d'Oncologie Ecole Nationale Vétérinaire de Lyon, France, and sections were processed as described in previous studies. 4,15,16,18,40,42 Two pathologists (T.M. and associate) and one cytologist (C.F.F.)…”

Section: Histological Evaluationmentioning

confidence: 99%

“…4,15,16,18,40,42,54 Cytological slides were examined by one cytologist (C.F.F.). Morphological criteria based on the updated Kiel histological and cytological classification was the same as previously published.…”

Section: Cytological Evaluationmentioning

confidence: 99%

A Morphological Study of 608 Cases of Canine Malignant Lymphoma in France With a Focus on Comparative Similarities Between Canine and Human Lymphoma Morphology

et al. 2010

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This study reports cytomorphological, histomorphological, and immunological characterization of 608 biopsy cases of canine malignant lymphoma, with epidemiological and clinical data, collected from 7 French veterinary pathology laboratories. It compares morphological characteristics of malignant lymphoma in canines, per the updated Kiel classification system, with those reported in humans, per the World Health Organization (WHO) classification system. Of tumors described, 24.5% and 75.5% were classified as low-and high-grade malignant lymphomas, respectively. Presenting clinical signs included generalized or localized lymphadenopathy (82.4%) and extranodal diseases (17.6%) involving the skin (12.34%) and other sites (5.26%). Immunohistochemistry confirmed 63.8% B-cell (CD3-, CD79aþ), 35.4% T-cell (CD3þ, CD79a-), and 0.8% null-cell (CD3-, CD79a-) lymphomas. Most B-cell cases (38.49%) were of high-grade centroblastic polymorphic subtype; most T-cell cases (8.55%), high-grade pleomorphic mixed and large T-cell lymphoma subtypes. Some B-cell tumors showed morphologic characteristics consistent with follicular lymphomas and marginal zone lymphomas per the Revised European American Classification of Lymphoid Neoplasms and WHO canine classification systems and the WHO human classification system. Unusual high-grade B-cell subtypes included an atypical high-grade small B-cell lymphoma (0.66%), Burkitt-type B-cell lymphoma (1.64%), plasmacytoid lymphoma (0.99%), and mediastinal anaplastic large B-cell lymphoma (0.16%). Unusual T-cell subtypes included a previously undescribed high-grade canine immunoblastic T-cell type (1.15%), a rare low-grade prolymphocytic T-cell lymphoma (0.16%), and a recently described high-grade canine T-cell entity-aggressive granulocytic large-cell lymphoma (0.16%). Marginal zone lymphomas were common (10.86%); follicular lymphomas were rare (0.49%). Canine primary cutaneous malignant lymphoma subtypes were present (11.84%). There was no significant difference between B-and T-cell malignant lymphoma in regard to canine age and sex. A significant overrepresentation of Boxers (24.19%) was found for T-cell lymphomas.

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“…Lymphoma accounts for approximately 7% up to 24% of all canine neoplasms and about 83% of all malignant haematopoietic tumors of this species (Valli et al, 2017;Vail et al, 2013 Comazzi and Gelain, 2011). The immunophenotype of a lymphocyte is identified by determining the expression of specific molecules for B lymphocytes (e.g., CD79a, CD20, CD21), and T lymphocytes (e.g., CD3) (Ponce et al, 2003;Vail et al, 2013). The term null cell is generally used for lymphocytes that have not been immunoreactive for B or T cells.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Characterization of Canine Lymphomas

Cora¹,

Gal²,

Taulescu³

et al. 2017

BUASVMCN-VM

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Lymphomas occur by clonal expansion of lymphoid cells and have distinctive morphological and immunophenotypic features. Determination of canine lymphoma immunophenotype is useful for accurate prognosis and further therapy. In the suggested study, we performed an immunohistochemical evaluation of some cases with canine lymphoma diagnosed in the Department of Pathology (Faculty of Veterinary Medicine, ClujNapoca, Romania), in order to characterize them. The investigation included 39 dogs diagnosed with different anatomical forms of lymphoma, following necropsy analysis or assessment of biopsies. The diagnosis of lymphoma was confirmed by necropsy and histopathology (Hematoxylin-eosin stain) examinations. The collected specimens were analyzed by immunohistochemistry technique (automatic method) using the following antibodies: CD3, CD20, CD21 and CD79a. The analyzed neoplasms were characterized as follows: about 64.10% of cases were diagnosed as B-cell lymphomas, 33.34% of cases as T-cell lymphomas, whereas 2.56% of cases were null cell type lymphomas (neither B nor T). Most of multicentric (80%), mediastinal (60%) and primary central nervous system lymphomas (100%) had B immunophenotype, while the majority of cutaneous (80%) and digestive (100%) lymphomas had T immunophenotype. Immunohistochemical description of canine lymphomas can deliver some major details concerning their behavior and malignancy. Additionally, vital prognosis and efficacy of some therapeutic protocols are relying on the immunohistochemical features of canine lymphoma.

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High-Grade Canine T-cell Lymphoma/Leukemia with Plasmacytoid Morphology: A Clinical Pathological Study of Nine Cases

Cited by 32 publications

References 21 publications

Proliferation activity in canine lymphomas

Proliferation activity in canine lymphomas

A Morphological Study of 608 Cases of Canine Malignant Lymphoma in France With a Focus on Comparative Similarities Between Canine and Human Lymphoma Morphology

Immunohistochemical Characterization of Canine Lymphomas

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