High-Frequency Ultrasound Measurements of the Normal Ciliary Body and Iris

Garcia, Julian P S; Spielberg, Leigh; Finger, Paul T.

doi:10.3928/15428877-20110603-03

Cited by 20 publications

(20 citation statements)

References 20 publications

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“…However, all measurements were within normative values. 22 In all patients, the PPPCE lesions appeared bright and were highly reflective. There was no evidence of the invasion of the stroma (Fig.…”

Section: High-frequency Ultrasound Imagingmentioning

confidence: 98%

Peripheral Pigmented Placoid Corneal Endotheliopathy

Chen

Finger

Dhrami-Gavazi

2013

Cornea

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Section: High-frequency Ultrasound Imagingmentioning

confidence: 98%

Peripheral Pigmented Placoid Corneal Endotheliopathy

Chen

Finger

Dhrami-Gavazi

2013

Cornea

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“…159 Iris and iridociliary melanomas can be measured accurately using high-frequency ultrasound also called "ultrasound biomicroscopy." [160][161][162][163] Introduced in 1991, ultrasound frequencies of 35 MHz-50 MHz permitted high-resolution imaging of tumors in the posterior iris and ciliary body. Highfrequency ultrasound measurements of iridociliary tumor size and apex height allowed for improved plaque-size selection, treatment planning, and tumor follow-up.…”

Section: Iris and Iridociliary Melanomasmentioning

confidence: 99%

Dosimetry of ¹²⁵I and ¹⁰³Pd COMS eye plaques for intraocular tumors: Report of Task Group 129 by the AAPM and ABS

et al. 2012

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Dosimetry of eye plaques for ocular tumors presents unique challenges in brachytherapy. The challenges in accurate dosimetry are in part related to the steep dose gradient in the tumor and critical structures that are within millimeters of radioactive sources. In most clinical applications, calculations of dose distributions around eye plaques assume a homogenous water medium and full scatter conditions. Recent Monte Carlo (MC)-based eye-plaque dosimetry simulations have demonstrated that the perturbation effects of heterogeneous materials in eye plaques, including the gold-alloy backing and Silastic insert, can be calculated with reasonable accuracy. Even additional levels of complexity introduced through the use of gold foil "seed-guides" and custom-designed plaques can be calculated accurately using modern MC techniques. Simulations accounting for the aforementioned complexities indicate dose discrepancies exceeding a factor of ten to selected critical structures compared to conventional dose calculations. Task Group 129 was formed to review the literature; re-examine the current dosimetry calculation formalism; and make recommendations for eye-plaque dosimetry, including evaluation of brachytherapy source dosimetry parameters and heterogeneity correction factors. A literature review identified modern assessments of dose calculations for Collaborative Ocular Melanoma Study (COMS) design plaques, including MC analyses and an intercomparison of treatment planning systems (TPS) detailing differences between homogeneous and heterogeneous plaque calculations using the American Association of Physicists in Medicine (AAPM) TG-43U1 brachytherapy dosimetry formalism and MC techniques. This review identified that a commonly used prescription dose of 85 Gy at 5 mm depth in homogeneous medium delivers about 75 Gy and 69 Gy at the same 5 mm depth for specific (125)I and (103)Pd sources, respectively, when accounting for COMS plaque heterogeneities. Thus, the adoption of heterogeneous dose calculation methods in clinical practice would result in dose differences >10% and warrant a careful evaluation of the corresponding changes in prescription doses. Doses to normal ocular structures vary with choice of radionuclide, plaque location, and prescription depth, such that further dosimetric evaluations of the adoption of MC-based dosimetry methods are needed. The AAPM and American Brachytherapy Society (ABS) recommend that clinical medical physicists should make concurrent estimates of heterogeneity-corrected delivered dose using the information in this report's tables to prepare for brachytherapy TPS that can account for material heterogeneities and for a transition to heterogeneity-corrected prescriptive goals. It is recommended that brachytherapy TPS vendors include material heterogeneity corrections in their systems and take steps to integrate planned plaque localization and image guidance. In the interim, before the availability of commercial MC-based brachytherapy TPS, it is recommended that clinical medical physicists use...

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“…7 Bony erosion has been frequently reported in allergic and fungal rhinosinusitis. 8 This patient had chronic sinusitis; however, Grocott stain was negative making a fungal cause unlikely. A dipicolinic acid stain for amyloid was also negative.…”

Section: Commentmentioning

confidence: 97%

“…1B). 8 On the basis of clinical findings, a differential of extrascleral extension of uveal melanoma, conjunctival melanoma, hemorrhagic cyst, and simulating lesions was considered. An excisional biopsy of the tumor was performed.…”

Section: Case Reportmentioning

confidence: 99%