High frequency ultrasound measurement of digital dermal thickness in systemic sclerosis

Kaloudi, Olga; Bandinelli, Francesca; Filippucci, Emilio; Conforti, Maria Letizia; Miniati, Irene; Guiducci, Serena; Porta, Francesco; Candelieri, Antonio; Conforti, Domenico; Grassiri, Genesio; Grassi, Walter; Matucci‐Cerinic, Marco

doi:10.1136/ard.2009.114843

Cited by 79 publications

(75 citation statements)

References 8 publications

(12 reference statements)

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“…At high-frequency ultrasound, dermal thickness of the dorsal side of the second finger is significantly higher in the edematous phase than in the fibrotic phase (25).…”

Section: Discussionmentioning

confidence: 92%

Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase

Bongi¹,

Rosso²,

Passalacqua³

et al. 2011

Arthritis Care & Research

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Objective. In systemic sclerosis (SSc; scleroderma) patients in edematous phase, hand edema is often present. Manual lymph drainage (MLD) stimulates the lymphatic system and reduces edema. Our aim was to evaluate the efficacy of MLD in reducing edema and in improving functionality of the hands and perceived quality of life (QOL) in SSc patients in edematous phase. Results. In the intervention group, hand volume, the HAMIS test, and the 4 VAS were improved significantly at the end of treatment (P < 0.001). The results were maintained at T2 (P < 0.001). The HAQ and the PSI and MSI of the SF-36 also improved significantly at T1 (P < 0.001), but only PSI improvement was maintained at T2 (P < 0.001). In the observation group, no improvement at T1 and at T2 was observed. Conclusion. In SSc, MLD significantly reduces hand edema and improves hand function and perceived QOL.

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“…At high-frequency ultrasound, dermal thickness of the dorsal side of the second finger is significantly higher in the edematous phase than in the fibrotic phase (25).…”

Section: Discussionmentioning

confidence: 92%

Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase

Bongi¹,

Rosso²,

Passalacqua³

et al. 2011

Arthritis Care & Research

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“…It can range from edema to fibrosis and eventually to atrophy because of the excessive dermal deposition of collagen and changes in the architecture of the connective tissue (16). Several studies have shown that the extent of skin involvement predicts internal organ involvement and general outcome of patients (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…Skin thickness assessment by palpation (modified Rodnan skin score) is widely used in SSc, but it is a qualitative method and has interobserver variability. High-frequency ultrasound has been suggested for the determination of skin thickness and echogenicity (16,19). However, it is not useful for assessment of skin elasticity.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the degree of skin fibrosis by sonoelastography and the degree of pulmonary involvement in scleroderma

Çildağ¹,

Çildağ²

2017

Turk J Med Sci

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Background/aim: This study aimed to assess the relationship between skin fibrosis as determined by sonoelastography and the degree of pulmonary involvement as determined by high-resolution computed tomography (HRCT) in patients with diffuse cutaneous systemic sclerosis (dcSSc). Materials and methods:This prospective study included 40 patients with dcSSc. All patients with HRCT scans underwent conventional ultrasonography and sonoelastography to determine skin thickness and degree of fibrosis. The degree of fibrosis was classified according to color-scale sonoelastography. The degree of pulmonary involvement was classified according to HRCT grading groups. The relationship between skin fibrosis and pulmonary involvement was investigated.Results: There was a statistically significant difference between HRCT grading groups according to the sonoelastographic color scale (P < 0.001). Sonoelastographic color-scale groups showed a statistically significant difference in duration of disease (P = 0.013). No significant difference was found between the sonoelastographic color-scale groups in age, sex, or skin thickness. Conclusion:Sonoelastography is a useful and reliable tool for assessing skin involvement in dcSSc. We found a good correlation between the degree of skin fibrosis as determined by sonoelastography and the degree of pulmonary involvement.

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“…Recent studies regarding 23 Na magnetic resonance imaging-determined tissue sodium speculated that the increasing skin Na + coincided with increasing glycosaminoglycan content in skin and that Na + concentrations can be quantified noninvasively in skin (36). Of interest, a recent study demonstrated the feasibility of a highly sensitive superconducting surface coil for microscopic MRI of the human skin in vivo in a clinical 1.5 Tesla scanner (37).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…Kaloudi et al (23) evaluated skin thickness in 70 patients with SSc at 2 different sites on the second digit of the dominant limb. Patients were divided into three subgroups according to the phase of the disease: edematous, fibrotic, and atrophic phase.…”

Section: Introductionmentioning

confidence: 99%

Skin imaging in systemic sclerosis

Kang¹,

Abignano²,

Lettieri³

et al. 2014

Eur J Rheumatol

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Fibrotic involvement of the skin is a cardinal feature of systemic sclerosis (SSc). The extent of skin involvement is associated with internal organ involvement, coinciding with more severe disease course and poor prognosis. A palpation-based semi-quantitative score, the modified Rodnan skin score, is widely used for the assessment of skin involvement, but it is entailed by significant limitations. More objective approaches to measure skin involvement employing imaging have been explored continuously in the past decades and are currently advancing. Here, we review the use of different imaging techniques for the assessment of skin involvement in patients with SSc, focusing mainly on ultrasound, magnetic resonance imaging, and optical coherence tomography.

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High frequency ultrasound measurement of digital dermal thickness in systemic sclerosis

Abstract: US is a reliable tool giving reproducible results, and is able to detect digital dermal thickening in SSc.

Cited by 79 publications

References 8 publications

Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase

Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase

The relationship between the degree of skin fibrosis by sonoelastography and the degree of pulmonary involvement in scleroderma

Skin imaging in systemic sclerosis

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