High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway

Yan, Junni; Zhang, Fuping; Niu, None Le; Wang, Xiaonan; Lu, Xinxin; Ma, Chaoyue; Zhang, Chencheng; Song, Jinggui; Zhao-hui, Zhang

doi:10.1016/j.brainresbull.2022.02.020

Cited by 10 publications

(2 citation statements)

References 53 publications

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“…Growing evidence indicates that mPFC plays a pivotal role in depressive-like behavior. Our results are in keeping with previous studies indicating that different HF-rTMS protocols induce antidepressant-like effects in rodents (Yang et al, 2007 ; Feng et al, 2012 ; Wang et al, 2014 ; Heath et al, 2018 ; Yan et al, 2022 ). Moreover, the protocols used in the aforementioned studies required longer stimulation, immobilization, and handling of animals which induce stress and a consequent detrimental effect on morphological and functional plasticity (Herman et al, 2003 ).…”

Section: Discussionsupporting

confidence: 93%

High-frequency rTMS modulates emotional behaviors and structural plasticity in layers II/III and V of the mPFC

Cambiaghi

Infortuna

Gualano

et al. 2022

Front. Cell. Neurosci.

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Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique, and it has been increasingly used as a nonpharmacological intervention for the treatment of various neurological and neuropsychiatric diseases, including depression. In humans, rTMS over the prefrontal cortex is used to induce modulation of the neural circuitry that regulates emotions, cognition, and depressive symptoms. However, the underlying mechanisms are still unknown. In this study, we investigated the effects of a short (5-day) treatment with high-frequency (HF) rTMS (15 Hz) on emotional behavior and prefrontal cortex morphological plasticity in mice. Mice that had undergone HF-rTMS showed an anti-depressant-like activity as evidenced by decreased immobility time in both the Tail Suspension Test and the Forced Swim Test along with increased spine density in both layer II/III and layer V apical and basal dendrites. Furthermore, dendritic complexity assessed by Sholl analysis revealed increased arborization in the apical portions of both layers, but no modifications in the basal dendrites branching. Overall, these results indicate that the antidepressant-like activity of HF-rTMS is paralleled by structural remodeling in the medial prefrontal cortex.

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Section: Discussionsupporting

confidence: 93%

High-frequency rTMS modulates emotional behaviors and structural plasticity in layers II/III and V of the mPFC

Cambiaghi

Infortuna

Gualano

et al. 2022

Front. Cell. Neurosci.

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“…The rescue of stress-induced deficits in behavioral assays by FGF2 and the blockade of fluoxetine and imipramine’s antidepressant effects by FGFR1 inhibitor suggests that FGF signaling is important for antidepressant activity (Elsayed et al, 2012 ). A recent rat study implicated FGF2 signaling in the antidepressant effects of high-frequency repetitive transcranial magnetic stimulation, attaching additional significance to this pathway in the treatment of depression (Yan et al, 2022 ). From a cellular mechanism standpoint, FGF2 effects appear to be exerted via its role in supporting gliogenesis in the PFC (Elsayed et al, 2012 ) and neurogenesis in the hippocampus (Cheng et al, 2015 ).…”

Section: Reviewmentioning

confidence: 99%

Antidepressant-like effects of trophic factor receptor signaling

Sathyanesan

Newton

2022

Front. Mol. Neurosci.

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A significant body of research has demonstrated that antidepressants regulate neurotrophic factors and that neurotrophins themselves are capable of independently producing antidepressant-like effects. While brain derived neurotrophic factor (BDNF) remains the best studied molecule in this context, there are several structurally diverse trophic factors that have shown comparable behavioral effects, including basic fibroblast growth factor (FGF-2), insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF). In this review we discuss the structural and biochemical signaling aspects of these neurotrophic factors with antidepressant activity. We also include a discussion on a cytokine molecule erythropoietin (EPO), widely known and prescribed as a hormone to treat anemia but has recently been shown to function as a neurotrophic factor in the central nervous system (CNS).

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The enhancing effects of heparin on the biological activity of FGF-2 in heparin−FGF-2−calcium phosphate composite layers

et al. 2022

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High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway

Cited by 10 publications

References 53 publications

High-frequency rTMS modulates emotional behaviors and structural plasticity in layers II/III and V of the mPFC

High-frequency rTMS modulates emotional behaviors and structural plasticity in layers II/III and V of the mPFC

Antidepressant-like effects of trophic factor receptor signaling

The enhancing effects of heparin on the biological activity of FGF-2 in heparin−FGF-2−calcium phosphate composite layers

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