High-frequency phase shift measurement greatly enhances the sensitivity of QCM immunosensors

Abstract

ElsevierMarch Iborra, MDC.; García Narbón, JV.; Sánchez, Á.; Arnau Vives, A.; Jiménez Jiménez, Y.; García, P.; Manclus Ciscar, JJ.... (2015). High-frequency phase shift measurement greatly enhances the sensitivity of QCM immunosensors. Biosensors and Bioelectronics. (65)

Critical overview on the application of sensors and biosensors for clinical analysis

“…The modes of delivering electric power to sensors and biosensors, that is, delivering alternating current (AC) or direct current (DC) [53] and the use of a specific frequency [54], can also be considered when improving the sensor output (i.e., analytical signal). Thus, the figures of merit of these sensing systems, such as sensitivity and LOD, can be enhanced.…”

“…Although the sensors were tested for BSA, they can be used to detect several other compounds with the AC measurement. Recently, March et al [54] proposed a highly sensitive and versatile QCM immunosensor with high fundamental frequency (HFF) for pesticide (carbaryl and thiabendazole) analysis. They also estimated the sensitivity of conventional QCM sensors via a novel electronic characterization approach based on phase change measurements at a constant fixed frequency.…”

“…In general, the current already established, commercialized systems employ frequencies ranging from 5 to 20 MHz. However, a suitable HFF is necessary for liquid applications requiring sensitive detection of small changes [54]. March et al [54] verified that the QCM immunosensor with an HFF of 100 MHz was most sensitive.…”

“…However, a suitable HFF is necessary for liquid applications requiring sensitive detection of small changes [54]. March et al [54] verified that the QCM immunosensor with an HFF of 100 MHz was most sensitive. On comparing these results with those reported for the 9-MHz QCM, an increase of one order of magnitude in sensitivity and two orders of magnitude in LOD was found (sensitivity of 30 μg L −1 and 0.66 μg L −1 , and LOD of 11 μg L −1 and 0.14 μg L −1 , for 9 and 100 MHz, respectively).…”

A quartz crystal microbalance study of the adsorption of benzene and acetone vapors onto coumarin-substituted manganese phthalocyanine film

“…Therefore, a considerable number of works have been focused on the development of organic-based sensors for the detection of benzene and acetone vapors. In this respect, quartz crystal microbalance-based sensors suffer many advantages over chemoresistive and optical sensors such as high sensitivity, short response and recovery times, portability, and simple instrumentation [7,8]. Responses of the quartz crystal microbalance (QCM) sensors vary in direct proportion to the extent of vapor sorption, which is typically rapid, reversible, and a linear function of vapor concentration [9].…”