High Frequency of Vitamin D Deficiency in Ambulatory HIV-Positive Patients

Rodríguez, Martínez; Daniels, Brodie; Gunawardene, S.; Robbins, Gregory K.

doi:10.1089/aid.2008.0183

Cited by 145 publications

(104 citation statements)

References 40 publications

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“…(26) when evaluating Spanish infected males, using reference levels of serum 25(OH) D less than 10ng/mL (26). Rodriguez, in the US, also reported hypovitaminosis D in 74.4% of infected adults aged 46 years, using reference levels of serum 25(OH) D less than 32 ng/mL (27).…”

Section: Possible Mechanisms Of Vitamin D Deficiency In Hiv-infected mentioning

confidence: 96%

Vitamin D deficiency in HIV-infected individuals: one more risk factor for bone loss and cardiovascular disease?

Conrado

Miranda-Filho

Bandeira³

2010

Arq Bras Endocrinol Metab

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SummaryThe epidemiological profile of the HIV virus has undergone substantial modifications with advances in antiretroviral therapy. There has been a sharp decline in morbi-mortality levels of HIVinfected patients, which has resulted in higher survival rates. The HIV seropositive population is living longer and more exposed to chronic complications caused by the disease itself and the prolonged use of antiretrovirals. Initially, metabolic alterations were reported, increasing cardiovascular disease risk. Subsequently, damage on bone metabolism was related. SumárioO perfil epidemiológico da infecção pelo vírus HIV vem sofrendo grandes modificações com os avanços na terapia antirretroviral. Houve uma queda expressiva na morbi-mortalidade do paciente infectado pelo HIV e, por conseguinte, aumento da sobrevida. A população soropositiva está envelhecendo e mais exposta às complicações da cronificação da doença e ao uso prolongado dos antirretrovirais. Inicialmente foram descritas alterações metabólicas que contribuem para um aumento no risco de doença cardiovascular. Em seguida, surgiram relatos de danos ao metabolismo ósseo. A deficiência de vitamina D tem atingido proporções epidêmicas envolvendo até mesmo indivíduos saudáveis em regiões tropicais. Dados recentes sugerem sua associação com síndrome metabólica, doenças imunes, diabetes e hipertensão. A doença HIV/Aids e a ação dos antirretrovirais no metabolismo da vitamina D ainda permanecem pouco conhecidas. Em pacientes HIV positivos, fatores ligados ao próprio vírus e ao uso dos antirretrovirais podem estar adicionados às demais causas de hipovitaminose D. Arq Bras Endocrinol Metab. 2010;54(2):118-22

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Section: Possible Mechanisms Of Vitamin D Deficiency In Hiv-infected mentioning

confidence: 96%

Vitamin D deficiency in HIV-infected individuals: one more risk factor for bone loss and cardiovascular disease?

Conrado

Miranda-Filho

Bandeira³

2010

Arq Bras Endocrinol Metab

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“…42,60 In some studies designed for the purpose, PTH concentration or prevalence of sHPTH was found to be consistently associated with 25OHD level and/or ART therapy (PIs and NNRTIs). 7,34,36,[39][40][41][42]45,51 Three articles, in particular, found a correlation between tenofovir use and higher parathyroid hormone concentrations. 7,36,39 In addition, Masia et al evaluated changes in PTH after the initiation of two different ART regimens.…”

Section: Secondary Hyperparathyroidism and Parathyroid Hormone Statusmentioning

confidence: 99%

“…10,35,37,40,45,51 For efavirenz, in particular, an association with low 25OHD concentration has often been suggested. 9,24,29,31,38 Similar but less consistent findings were observed for some nucleoside reverse transcriptase inhibitor (NRTIs), such as emtricitabine, tenofovir, and zidovudine.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

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Vitamin D deficiency in HIV-infected patients: a systematic review

Giusti¹,

Penco²,

Pioli³

2011

NDS

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Advances in the diagnosis and management of human immunodeficiency virus (HIV) have resulted in a dramatic decrease in mortality in HIV-infected individuals (HIV+). The subsequent increase in life expectancy of HIV+ has led to the need to consider the long-term complications of the disease and its treatment. Abnormalities in vitamin D status and metabolism are increasingly recognized as a major concern in HIV infection. In the last 5 years a number of cross-sectional and prospective studies have suggested a high prevalence of vitamin D deficiency in HIV+. Although few case-control studies have been published, it has been suggested that the prevalence of hypovitaminosis D in HIV+ is higher than in the general population, and at least in part, is related to the course of the disease and/or the antiretroviral drugs used to treat the disease. An adequate vitamin D status is important not only for bone tissue, but also for the global health status of HIV+ individuals, since a growing body of evidence has demonstrated the detrimental effects of vitamin D deficiency on multiple health outcomes. Therefore, definition of the size of the problem and identification of effective protocols for the prevention and management of vitamin D deficiency in HIV+ patients represent important steps in improving health status and reducing long-term chronic complications in individuals with HIV. Due to its immunomodulatory effects, vitamin D may also have implications in the progression of HIV infection. This systematic review was designed to determine the prevalence of vitamin D deficiency in HIV+ patients; to identify risk factors (related to the HIV infection or not) potentially associated with this condition; to describe the potential consequences of hypovitaminosis D on the course of the infection and the benefits of vitamin D repletion; and to make some suggestions about the future, considering the limitations of previous studies.

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“…In the present study, 94.8% of the participants were undergoing HAART, and 36.5% of the patients were taking efavirenz. Efavirenz, an NNRTI antiretroviral, has been associated with decreased serum vitamin D levels and can be a risk factor for reduced serum vitamin D levels (3) (14) . This could also help explain the possible relationship between HAART and vitamin D status.…”

mentioning

confidence: 99%

Prevalence of hypovitaminosis D and its association with oral lesions in HIV-infected Brazilian adults

Ferreira

Lima

Omena

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:This study assessed the prevalence of hypovitaminosis D and its association with oral candidiasis and clinical parameters of periodontitis (CPP) in HIV-infected patients. Methods: Periodontal examinations for the 113 HIV-infected patients were recorded using the Community Periodontal Index. A cytological smear from the lateral borders of the tongue was performed to evaluate candidiasis. Results: The frequency of hypovitaminosis D was 23.9%. In multivariate analysis, only the duration of exposure to HIV was associated with CPP .00)]. Conclusions: The prevalence of hypovitaminosis D was 23.9% and was not related with oral candidiasis or CPP.

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High Frequency of Vitamin D Deficiency in Ambulatory HIV-Positive Patients

Cited by 145 publications

References 40 publications

Vitamin D deficiency in HIV-infected individuals: one more risk factor for bone loss and cardiovascular disease?

Vitamin D deficiency in HIV-infected individuals: one more risk factor for bone loss and cardiovascular disease?

Vitamin D deficiency in HIV-infected patients: a systematic review

Prevalence of hypovitaminosis D and its association with oral lesions in HIV-infected Brazilian adults

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