High frequency of the IL-2 −330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis

Shahbazi, Majid; Roshandel, Danial; Ebadi, H.; Fathi, Davood; Zamani, Mahdi; Boghaee, Mojdeh; Mohammadhoseeeni, Mana; Rshaidbaghan, Azam; Bakhshandeh, Azam; Shahbazi, Saleh

doi:10.1016/j.clim.2010.05.010

Cited by 17 publications

(13 citation statements)

References 30 publications

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“…The recruited patients originated from south west of Iran. Our results are in line with most of the other previous studies in different ethnic groups in Iran [5][6][7]9] and European populations [12][13][14][15]25]. So we can conclude that HLA-DRB1*1501 can be considered as a strong genetic risk factor for MS in our population.…”

supporting

confidence: 82%

“…The results of the current study are similar to four of them [5][6][7]9] but different from one of them [8]. However, it should be noted that our allelic frequency was more than most of these studies in Iran and this may be due to different genetic pools and ethnic diversity in Khuzestan province.…”

Section: Discussionsupporting

confidence: 49%

“…Logistic regression analysis failed to show any association between HLA-DRB1*1501 and EDSS of MS; EDSS of MS in our sample of patients were similar to features published in observational studies of MS [7,9,14]. This suggests that DRB1*1501 may be exerts a susceptibility rather than disease modifying effect in MS.…”

supporting

confidence: 57%

“…Although several studies have been carried out on the association of DRB1*1501 with MS in Iran [6][7][8][9], there are no data so far about this issue in Khuzestan province. Given the ethnicity diversion in Khuzestan province and also due to the fact that unlike Persians, Arabs in Iran are mostly located in Khuzestan and since there are a few data in this regard in Arabic countries, this population study can be of great importance.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

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Background: Multiple sclerosis (MS) is a demyelinating, autoimmune and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors. The contribution of HLA-DRB1*1501 to MS risk has been replicated and confirmed in most population-based studies. Since there are no data with respect to the association of HLA-DRB1*1501 and MS in Khuzestan province. Objectives: The aim of this study was to investigate the correlation of this allele with MS in Khuzestan province. Methods: In this case-control study, DRB1*1501 allele was analyzed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 200 MS patients and 200 unrelated healthy individuals, without any autoimmune disease from the same geographical region. The frequencies of the mentioned allele were compared between the patients and control group using SPSS 16 statistical software and the chi square test. Results:The results demonstrated that distribution of DRB1*1501 allele was statistically different between patient and control (41.5% vs. 22.81%, P < 0.001); significant correlation was observed among these allele with both Arab (28.84% vs. 50.84%, P = 0.005) and Persian (15.87% vs. 35.55%, P = 0.018) ethnicities; although no association was revealed between mentioned allele and disease clinical course (relapsing-remitting, secondary-progressive, progressive-relapsing and primary-progressive), expanded disability scale score (EDSS) and gender. Conclusions:The study presents association of susceptibility to multiple sclerosis in southwest of Iran with HLA-DRB1*1501 allele in both Arab and Persian ethnic; although DRB1*1501 may be is not involved in the pathogenesis of different MS disease subtypes. The results are consistent with most of the other studies in Iran; and also most studies in European populations.

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supporting

confidence: 82%

Section: Discussionsupporting

confidence: 49%

supporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Since we have some recent findings to support a role for HLA-DRB1 as the most important gene in susceptibility to MS in Caucasian and Iranian patients [11,16,17]. Therefore this study was designed to evaluate the association between HLA-DRB1 genotype and clinical response to IFNβ among Iranian MS patients.…”

Section: Introductionmentioning

confidence: 96%