High frequency of T lineage lymphocytes in nude mouse spleen

Cellular Mechanisms in the Protection against Infection by Listeria monocytogenes in Mice

“…Thus, nude mice may have more depressed functions of T lymphocytes than THXB mice. Studies of nude mice may provide a new method for analysing the contribution of T cell-mediated immunity to the protection against at least some micro-organisms, although 0-positive cells still exist in nude mice (Loor & Roelants, 1974) and they increase in number in nude mice infected with mouse hepatitis virus (Scheid, Goldstein & Boyse, 1975).…”

The Transplantation Barrier of Nude Mice

“…Immunofluorescence studies demonstrated, on the other hand, the presence of Thy-1-positive T cell precursors in the bone marrow and the peripherallymphoid tissues of nude mice (16,17). These investigations have led to the view that athymic nude mice possess immature precursors of functional T cells whose maturation is blocked in the absence of thymic influence.…”

Coxsackievirus B 1-induced polymyositis. Lack of disease expression in nu/nu mice.

“…Nude mice have been a useful experimental animal for examination of T cell deficiency in immunologic and oncologic research but the age ofanimals isan important variable in the interpretation ofresults. Cells bearing T cell antigens can be found in nu/nu mice (35,36). The origin of these cells has been debated but T cell progenitors are present and can be induced to differentiate into Thy-l+ cells by in vivo administration of thymopoietin (37).…”