High frequency of methicillin‐susceptible and methicillin‐resistant Staphylococcus aureus in children under 1 year old with skin and soft tissue infections

Salazar-Ospina, Lorena; Jiménez, J. Natalia

doi:10.1016/j.jpedp.2017.10.002

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…This result may be associated with the wide dissemination of strains carrying specific genes (like mecA) that were identified as CNS, since the species that compose them also have this gene widely disseminated, in various species of clinical interest. [17][18][19][20] The resistance patterns found for the antibiotics chloramphenicol, penicillin and linezolid corroborate the studies carried out with S. aureus, 14,[15][16][17][18]20 emphasizing that penicillin is not a viable therapeutic option for most cases. The resistance pattern for tetracycline diverged from the previous study 17 which demonstrated a resistance around 30%, unlike this one, in which the levels were around 20%.…”

Section: Discussionsupporting

confidence: 69%

“…Although the presence of Staphylococcus spp. in the patient's microbiota, this group can be the causative agent of infections in the most diverse body sites; such as the skin, airways, soft tissue, conjunctiva and bloodstream, [14][15][16][17] affecting patients of different ages and of both sexes. 16 In this work, it was observed that most of the isolates were from CNS, given that these diverge from the findings described by other studies 17,19 which aimed to evaluate the resistance profile of S. aureus and CNS in blood culture samples.…”

Section: Discussionmentioning

confidence: 99%

“…The resistance observed in the antibiotics erythromycin, trimethoprim, norfloxacin, cefoxitin, azithromycin and gentamicin were lower than those identified in our study. 14-18, 20, 23 Nevertheless, the studies mentioned were carried out in multiple anatomical sites, such as those of conjunctival origin, keratitis and blood cultures [14][15][16][17][18]20 of patients who occupied different hospital environments. The main isolation site for strains with strong and moderate biofilm production in association with methicillin resistance described in this study was the ICU and the high-complexity room, sectors of high and low turnover, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Identification and characterization of bacterial biofilm production in clinical isolates of Staphylococcus spp. against antimicrobials

Martins

Silva

Neto

et al. 2021

Rev Epidemiol Control Infect

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Justification and Objectives: Circulating blood is sterile and the presence of microorganisms can be of clinical interest, especially in the hospital environment, being able to cause infectious processes and substantially increase morbidity and mortality. The objective of this work was to characterize the isolates of the genus Staphylococcus spp. from bloodstream infections as to the production of bacterial biofilm and resistance to the main antimicrobials used in clinical practice. Methods: Blood cultures were collected with an indication of positivity for bacterial growth from multiple sectors of the study hospital, which were subsequently processed to identify the bacterial genus through the use of phenotypic tests for Gram positive bacteria. The verification of the resistance profile was performed following the Kirby-Bauer disk diffusion. The identification of the production and quantification of the bacterial biofilm occurred following the protocol described by O’toole (2010). Results: The most frequent clinical isolate was Coagulase negative Staphylococci 38 (54.29%), followed by Staphylococcus aureus 32 (45.71%). Resistance to erythromycin, norfloxacin, levofloxacin and azithromycin was observed in most isolates (70%). Regarding methicillin, more MRSA (59.38%) than MR-CONS (47.37%) were isolated. The ICU was the place where the formation of the biofilm showed indicative data of greater adherence, which was associated with MRSA strains. Conclusion: The bacterial isolates associated with bloodstream infections showed high resistance to antimicrobials. The presence of MRSA and MR-CONS with strong and/or moderate biofilm production capacity represents a greater risk to the health of patients affected by infections caused by these agents.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Identification and characterization of bacterial biofilm production in clinical isolates of Staphylococcus spp. against antimicrobials

Martins

Silva

Neto

et al. 2021

Rev Epidemiol Control Infect

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“…It is unclear whether the same management is recommended for all ages of children. Some reports have indicated that SSTI in younger children are more likely to be caused by S. aureus, especially MRSA, than SSTI in older children (Salazar-Ospina and Jiménez 2018;Yueh et al 2022). Aggressive surgical intervention and empirical antibiotic therapy for MRSA may be recommended, not only in severe SSTI cases, but also in younger children, especially as SSTI due to CA-MRSA is also on the rise in Japan.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Extensive Subcutaneous Abscess due to Panton-Valentine Leucocidin-Positive Community-Associated Methicillin-Resistant <i>Staphylococcus aureus</i> in an Infant

Fujita

Matsudera

Watanabe

et al. 2022

Tohoku J. Exp. Med.

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Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have increased worldwide in people without underlying diseases. CA-MRSA can often cause serious bacterial infections, especially skin and soft tissue infections (SSTI). Here, we describe a case of severe subcutaneous abscess due to Panton-Valentine leucocidin (PVL)positive CA-MRSA in an infant without underlying diseases. A 4-month-old girl presented with a 4-day history of fever, with extensive redness and swelling of the lumbar region and buttocks. She was diagnosed with extensive subcutaneous abscess of the lumbar region and buttocks. Surgical drainage was performed, and a substantial volume of pus was drained.MRSA was detected in the pus on culture. Antibiotic therapy that covered MRSA was also administered for 3 weeks, and the abscess healed. As it was a severe SSTI due to MRSA, analysis of MRSA revealed PVL-positive MRSA. This patient had no underlying disease or history of antibiotic administration and as MRSA was present in the nasopharyngeal cavity, it was considered a case of CA-MRSA. Furthermore, the prevalence of PVL-positive CA-MRSA in MRSA isolated from patients with SSTI has also increased in Japan. The Infectious Diseases Society of America recommends surgical intervention and empirical antibiotic therapy for MRSA-complicated SSTI cases in an era of CA-MRSA. Pediatricians must strongly consider the possibility of MRSA in children with severe SSTIs.

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“…Healthcare-associated MSSA (HA-MSSA) infection was defined if the positive culture of MSSA was obtained on or after the third day of admission to a hospital. 21 The Ethics Committee of the Shahid Beheshti University of Medical Sciences in Tehran, Iran approved this research (IR. SBMU.…”

Section: Study Design Identification Of Isolate and Ethics Statementmentioning

confidence: 99%

Genetic analysis of methicillin‐susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug‐resistant ST239 with strong biofilm‐production ability

Goudarzi

Sabzehali

et al. 2020

Clinical Laboratory Analysis

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High frequency of methicillin‐susceptible and methicillin‐resistant Staphylococcus aureus in children under 1 year old with skin and soft tissue infections

Cited by 4 publications

References 25 publications

Identification and characterization of bacterial biofilm production in clinical isolates of Staphylococcus spp. against antimicrobials

Identification and characterization of bacterial biofilm production in clinical isolates of Staphylococcus spp. against antimicrobials

Extensive Subcutaneous Abscess due to Panton-Valentine Leucocidin-Positive Community-Associated Methicillin-Resistant <i>Staphylococcus aureus</i> in an Infant

Genetic analysis of methicillin‐susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug‐resistant ST239 with strong biofilm‐production ability

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