High frequency of Merkel cell polyomavirus DNA in the urine of kidney transplant recipients and healthy controls

Signorini, Lucia; Belingheri, Mirco; Ambrogi, Federico; Pagani, Elisabetta; Binda, Sandro; Ticozzi, Rosalia; Ferraresso, Mariano; Ghio, Luciana; Giacon, Bruno; Ferrante, Pasquale; Delbue, Serena

doi:10.1016/j.jcv.2014.10.012

Cited by 34 publications

(34 citation statements)

References 25 publications

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“…6,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] PyV-induced carcinogenesis has been explored through animal research models and studies based on Merkel cell carcinoma (MCC), a rare neuroendocrine cutaneous cancer wherein malignant transformation is mediated by the MCC polyomavirus (MCCPyV). 6,22,23 MCC is the first human malignancy reported to develop predominantly from PyV infections. 19 Studies document MCCPyV involvement in 80% of MCC cases worldwide; meanwhile, MCCPyV infection is ubiquitous and predominantly latent in otherwise healthy individuals.…”

Section: Human Polyomavirusesmentioning

confidence: 99%

“…19 Studies document MCCPyV involvement in 80% of MCC cases worldwide; meanwhile, MCCPyV infection is ubiquitous and predominantly latent in otherwise healthy individuals. 6,22,23 Other studies proposed PyV involvement in other human malignancies including certain variants of urothelial bladder carcinoma, 18,24,25 salivary gland cancers, 26 and colorectal carcinomas. 27 …”

Section: Human Polyomavirusesmentioning

confidence: 99%

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Significance, cytomorphology of decoy cells in polyomavirus-associated nephropathy: Review of clinical, histopathological, and virological correlates with commentary

Chantziantoniou

Joudeh

Hamed

et al. 2016

Journal of the American Society of Cytopathology

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Section: Human Polyomavirusesmentioning

confidence: 99%

Section: Human Polyomavirusesmentioning

confidence: 99%

Significance, cytomorphology of decoy cells in polyomavirus-associated nephropathy: Review of clinical, histopathological, and virological correlates with commentary

Chantziantoniou

Joudeh

Hamed

et al. 2016

Journal of the American Society of Cytopathology

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“…KIPyV DNA or VP1 protein was found in lung cancer tissue and in alveolar macrophages and spleen (Babakir-Mina et al, 2009;Siebrasse et al, 2014). MCPyV seems to be a common skin commensal (Bellaud et al, 2014;Hampras et al, 2015;Mertz et al, 2013;Schowalter et al, 2010), but DNA is also found in blood, eyebrow hairs, tonsils, gall bladder, intestine, appendix, liver, lung, lymphoid tissue, saliva and oral samples, and urine (reviewed by Baez et al, 2013;Hampras et al, 2015;Signorini et al, 2014). HPyV6 and HPyV7 are common in skin and eyebrow hairs (Bellaud et al, 2014;Hampras et al, 2015;Schowalter et al, 2010;Wieland et al, 2014), but have in very few cases been isolated from nasopharyngeal swabs, faeces or urine (Siebrasse et al, 2012b).…”

Section: Introductionmentioning

confidence: 99%

Early and late promoters of BK polyomavirus, Merkel cell polyomavirus, Trichodysplasia spinulosa-associated polyomavirus and human polyomavirus 12 are among the strongest of all known human polyomaviruses in 10 different cell lines

Moens

Ghelue

Ludvigsen

et al. 2015

Journal of General Virology

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Early and late promoters of BK polyomavirus, Merkel cell polyomavirus, Trichodysplasia spinulosa-associated polyomavirus and human polyomavirus 12 are among the strongest of all known human polyomaviruses in 10 different cell lines Little is known about cell tropism of the novel HPyVs, and cell cultures allowing virus propagation are lacking. Because viral tropism partially depends on the interaction of cellular transcription factors with the viral promoter, we monitored the promoter activity of all known HPyVs. Therefore, we compared the relative early and late promoter activity of the BK polyomavirus (BKPyV) (WW strain) with the corresponding activities of the other HPyVs in 10 different cell lines derived from brain, colon, kidney, liver, lung, the oral cavity and skin. Our results show that the BKPyV, MCPyV, TSPyV and HPyV12 early promoters displayed the strongest activity in most cell lines tested, while the remaining HPyV had relative low early promoter activity. HPyV12 showed the highest late promoter activity of all HPyVs in most cell lines, but also the BKPyV, MCPyV and TSPyV late promoters belonged to the stronger ones among HPyVs. The HPyVs with weak early promoter activity had in general also weak late promoter activity, except for HPyV10 whose late promoter was relatively strong in six of the 10 cell lines. A 20 bp deletion in the promoter of an HPyV12 variant significantly affected both early and late promoter activity in most cell lines. In conclusion, our findings suggest which cell lines may be suitable for virus propagation and may give an indication of the cell tropism of the HPyVs.

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“…Despite the rarity of MCC, MCPyV is a common skin commensal, found in healthy individuals. It has also been detected in urine, in immunosuppressed organ transplant recipients and non-immunosuppressed subjects (Husseiny et al 2010;Signorini et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Polyomavirus infections are common, ranging from 60 to 100 % depending on the virus (Signorini et al 2014). JC and BK are among the first human PyVs discovered.…”

Section: Discussionmentioning

confidence: 99%

First Detection of Human Papillomaviruses and Human Polyomaviruses in River Waters in Italy

et al. 2015

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Waterborne exposure to human viruses is possible through contact with contaminated water environments and can result in infections associated with a wide range of illnesses, including gastrointestinal, respiratory, ear, ocular, and skin infections. Recently, the occurrence in water environments of two groups of human viruses-both known with oncogenic potential, human polyomaviruses (HPyVs) and papillomaviruses (HPVs)-has been reported worldwide. These viruses, responsible for highly prevalent infections worldwide, have recently been proposed as potentially emerging waterborne pathogens. The objective of the present study was to examine the occurrence of HPyVs and HPVs in surface waters, by monitoring two rivers in Northwestern Italy, by nested PCR assays and sequencing. HPyVs (JC, BK, and Merkel cell polyomavirus) were detected in 10/25 (40%) samples. HPVs (HPV8, 17, 21, 25, 32, 80, 99, 105, and putative new HPVs) were identified in 14/25 (56%) river samples. The number of HPV DNA copies in waters was measured by quantitative real-time PCR. To our knowledge, this is the first detection and quantification of HPVs in surface waters. The possibility that HPyVs and HPVs can be transmitted by the waterborne route deserves to be explored in future studies.

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High frequency of Merkel cell polyomavirus DNA in the urine of kidney transplant recipients and healthy controls

Cited by 34 publications

References 25 publications

Significance, cytomorphology of decoy cells in polyomavirus-associated nephropathy: Review of clinical, histopathological, and virological correlates with commentary

Significance, cytomorphology of decoy cells in polyomavirus-associated nephropathy: Review of clinical, histopathological, and virological correlates with commentary

Early and late promoters of BK polyomavirus, Merkel cell polyomavirus, Trichodysplasia spinulosa-associated polyomavirus and human polyomavirus 12 are among the strongest of all known human polyomaviruses in 10 different cell lines

First Detection of Human Papillomaviruses and Human Polyomaviruses in River Waters in Italy

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