Significance, cytomorphology of decoy cells in polyomavirus-associated nephropathy: Review of clinical, histopathological, and virological correlates with commentary

Chantziantoniou, Nikolaos; Joudeh, Amani; Hamed, Radi; Al‐Abbadi, Mousa A.

doi:10.1016/j.jasc.2015.11.004

Cited by 5 publications

(6 citation statements)

References 52 publications

(174 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nankivell et al reported that urine SV40 immunostaining improves the diagnostic test characteristics compared with positive decoy cells in urine cytology; urine SV40 immunostaining was positive in 11.2% of samples (18/161 blocks) and showed better sensitivity (85.7% vs 66.7%, respectively), specificity (92.3% vs 88.6%, respectively), PPV (33.3% vs 11.7%, respectively), and NPV (99.3% vs 98.5%, respectively) for 161 blocks in which cellular sediments were sufficient after urine cytospin. 19 The diagnostic accuracy was greater than that observed in the present study via recognition of tubular cells with a nonclassic morphology (e.g. ruptured or fragmented morphology) using SV40 immunostaining after urine cytospin.…”

Section: Discussioncontrasting

confidence: 71%

See 1 more Smart Citation

Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients

Sekito¹,

Araki²,

Yoshinaga³

et al. 2021

Int J of Urology

View full text Add to dashboard Cite

Objectives: To investigate the association between duration of consecutive presence of decoy cells on urine cytology and BK virus nephropathy after kidney transplantation. Methods: In total, 121 kidney transplant recipients were retrospectively evaluated. The best duration of consecutive presence of decoy cells that could be used to predict BK virus nephropathy was analyzed using the area under the curve for each duration, and recipients were divided into two groups based on the best predictive performance. The effectiveness of SV40 immunostaining on urinary cytology was also analyzed. Results: In total, 2534 urine specimens as well as SV40 immunostaining in 2241 urine specimens were analyzed. Six consecutive months of decoy cell positivity had the best predictive performance for BK virus nephropathy (area under the curve = 0.832). The incidence of BK virus nephropathy in recipients with positive decoy cells for 6 months or more consecutive months (5/44) was significantly higher than in those who had positive decoy cells for less than 6 months (0/77; P = 0.005). Decoy cell positivity had a sensitivity, specificity, positive predictive value, and negative predictive value for BK virus nephropathy of 100%, 66%, 11%, and 100% respectively. SV40 immunostaining provided slightly better specificity (68%) and positive predictive value (12%). Conclusions: The detection of decoy cells at 6 months or more on urine cytology had high predictive value for BK virus nephropathy in kidney transplant recipients. SV40 immunostaining on urine cytology added minimal diagnostic accuracy.

show abstract

Section: Discussioncontrasting

confidence: 71%

“…Decoy cells were characterized as having enlarged nuclei with homogenous, intranuclear ground-glass like particles and condensed chromatin. 8,19…”

Section: Urine Cytologymentioning

confidence: 99%

Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients

Sekito¹,

Araki²,

Yoshinaga³

et al. 2021

Int J of Urology

View full text Add to dashboard Cite

show abstract

“…Often a difficult task, the distinction could be made based on the cellularity and the nuclear membrane irregularity . Table summarizes the cytologic features helpful in the differential diagnosis between degenerated urothelial cells, decoy cells and malignant urothelial cells . In a study of BKV‐associated urothelial carcinoma available only in abstract form, urine cytology showed a small cell (“HSIL‐like”) pattern in three of four cases, while the remaining case showed a pleomorphic pattern …”

Section: Discussionmentioning

confidence: 99%

“…45 Table 2 summarizes the cytologic features helpful in the differential diagnosis between degenerated urothelial cells, decoy cells and malignant urothelial cells. 46 In a study of BKV-associated urothelial carcinoma available only in abstract form, urine cytology showed a small cell ("HSIL-like") pattern in three of four cases, while the remaining case showed a pleomorphic pattern. 47 Similar to Epstein-Bar virus and human papilloma virus, it is thought that immunosuppression plays a key role in the oncogenicity of BKV as it is known to inhibit the body's immunologic control of the BKV replication and immunosurveillance.…”

mentioning

confidence: 97%

Unusual BK polyomavirus‐associated urologic malignancies in renal transplant recipients: Report of two cases and review of the literature

Odetola

Isaila

Pambuccian

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

Renal transplant recipients are at increased risk of developing urologic malignancies, some of which are associated with prolonged BK virus infection. We report two cases of BK virus-associated carcinoma with variant morphological patterns (clear cell adenocarcinoma of the bladder and micropapillary urothelial carcinoma of the pelvicaliceal system) arising in the urinary tract of renal transplant recipients. In both cases, the diagnosis was initially established on cytologic specimens: on urine cytology in one patient and on fine needle aspiration of an inguinal lymph node in the other patient. The unusual cytologic features of both cases (multiple morphologies in one patient and micropapillary pattern in the other), co-occurrence of decoy cells in the urine of one patient and the occurrence of these tumors in renal transplant recipients raised the possibility of BK polyomavirus-associated malignancy and led to confirmatory SV40 immunostains that were positive. These cases expand the morphologic variants of BK virus-associated urologic malignancies diagnosed in solid organ transplant patients. While differentiating BK virus-infected cells from malignant cells in urine cytology specimens is a diagnostic challenge, greater awareness of their possible co-existence is vital, as this could be the only chance for an early diagnosis.

show abstract

“…Interestingly, over 80% of immunocompetent adults are seropositive for BKV as previously reported ( Supplementary Table 1 ), but BKVAN occurs almost exclusively in KTRs, which raises concerns on the underlying pathogenesis mechanisms and attracts mounting concern as number of worldwide kidney transplants increases. BKVAN is clinically confirmed by tissue biopsy, and then clinical management through immunosuppression modulation is essential to balance exacerbation of the disease and acute rejection ( Chantziantoniou et al., 2016 ). It was reported that about 60% of KTRs have detectable BK viruria, and up to 10% of the patients develop BKVAN ( Babel et al., 2011 ; Chen et al., 2020 ).…”

Section: Bkv Reactivation and Its Potential Mechanismsmentioning

confidence: 99%

BK polyomavirus: latency, reactivation, diseases and tumorigenesis

Zhou,

Zhu,

2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world. In general, BKV stays latent and symptomless reactivation in healthy individuals. BKV has been mainly interlinked with BKV-associated nephropathy (BKVAN) in kidney-transplant recipients and hemorrhagic cystitis (HC) in hematopoietic stem cell transplant recipients (HSCTRs). However, the mechanisms underlying BKV latency and reactivation are not fully understood and lack of extensive debate. As Merkel cell polyomavirus (MCV) was identified as a pathogenic agent of malignant cutaneous cancer Merkel cell carcinoma (MCC) since 2008, linking BKV to tumorigenesis of urologic tumors raised concerns in the scientific community. In this review, we mainly focus on advances of mechanisms of BKV latency and reactivation, and BKV-associated diseases or tumorigenesis with systematical review of formerly published papers following the PRISMA guidelines. The potential tumorigenesis of BKV in two major types of cancers, head and neck cancer and urologic cancer, was systematically updated and discussed in depth. Besides, BKV may also play an infectious role contributing to HIV-associated salivary gland disease (HIVSGD) presentation. As more evidence indicates the key role of BKV in potential tumorigenesis, it is important to pay more attention on its etiology and pathogenicity in vitro and in vivo.

show abstract

Significance, cytomorphology of decoy cells in polyomavirus-associated nephropathy: Review of clinical, histopathological, and virological correlates with commentary

Cited by 5 publications

References 52 publications

Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients

Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients

Unusual BK polyomavirus‐associated urologic malignancies in renal transplant recipients: Report of two cases and review of the literature

BK polyomavirus: latency, reactivation, diseases and tumorigenesis

Contact Info

Product

Resources

About