High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia

Al-Sultan, Ali Ibrahim; Evans, Benjamin A.; Elsayed, Elsayed A.; Althawadi, Sahar; Al‐Taher, Abdulla; Amyes, Sebastian G. B.; Al-Dughaym, A. M.; Hamouda, Ahmed

doi:10.1099/jmm.0.057216-0

Cited by 37 publications

(44 citation statements)

References 20 publications

(25 reference statements)

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“…The VIM enzyme is by far the most the predominant metallo-␤-lactamase to be detected in as many as 95% (254/271) of carbapenem resistant A. baumannii the isolates from Saudi Arabia (Alsultan et al, 2013) but this was not observed in our study as only 2 isolates were positive for bla VIM-2 carbapenemase.…”

Section: Isolatecontrasting

confidence: 80%

“…There have been reports of CRAB in patients with diabetes mellitus in Saudi Arabia. They have become a serious problem in immunocompromised patients and the scenario is particularly worrying in Middle-Eastern countries due to the increasing number of infections that are difficult to treat (Alsultan et al, 2009(Alsultan et al, , 2013. The aim of this study was to characterise and understand the molecular epidemiology of clinical isolates of A. baumannii from two medical centres in Saudi Arabia and two from Egypt, collected in 2013 and 2014.…”

Section: Introductionmentioning

confidence: 99%

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The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt

Lopes

Al-Agamy

Ismail

et al. 2015

International Journal of Medical Microbiology

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Section: Isolatecontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt

Lopes

Al-Agamy

Ismail

et al. 2015

International Journal of Medical Microbiology

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“…The results of Alsultan et al (2013) are unusual by international standards, where the most frequent carbapenem-hydrolysing b-lactamases in A. baumannii are oxacillinases (OXA-23, OXA-40, OXA-58 and OXA-143) (Nordmann, 2010). Many reports from the Kingdom confirmed the prevalence of oxacillinases (particularly OXA-23) among carbapenem-resistant A. baumannii.…”

Section: A Baumanniimentioning

confidence: 65%

“…In a recent multicentre study including 37 Saudi hospitals, Alsultan et al (2013) investigated the molecular basis of resistance in 196 carbapenem-resistant A. baumannii isolated between 2008 and 2011. A high proportion of isolates (99 %) carried genes for at least one acquired carbapenem-hydrolysing b-lactamase.…”

Section: A Baumanniimentioning

confidence: 99%

The molecular basis of β-lactamase production in Gram-negative bacteria from Saudi Arabia

Yezli

Shibl

Memish

2015

Journal of Medical Microbiology

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Resistance to b-lactams among Gram-negative bacteria is a worldwide issue. Increased prevalence of extended-spectrum b-lactamase (ESBL)-producers and the dissemination of carbapenem-resistance genes are particularly concerning. ESBL-producing strains are common in the Kingdom of Saudi Arabia, particularly among the Enterobacteriaceae, and carbapenem resistance is on the increase, especially among the non-fermenters. b-lactamase production is a major mechanism of resistance to these agents and although b-lactamase-producing strains have been documented in the Kingdom, relatively few reports characterized the molecular basis of this production. Nevertheless, available data suggest that CTX-M (CTX-M-15 in particular) is the predominant ESBL in the Enterobacteriaceae, with SHV also being prevalent in Klebsiella pneumoniae. Carbapenem resistance in the latter is mainly due to OXA-48 and NDM-1. In Pseudomonas aeruginosa, VEB-like enzymes are the most common ESBLs, and VIM is the prevalent metallo-b-lactamase. OXA-10 extended-spectrum enzymes are also frequent. PER and GES ESBLs have been reported in Acinetobacter baumannii, and oxacillinases (OXA-23 in particular) are the dominant carbapanamases in this species. IntroductionInfections due to Gram-negative bacteria are a leading cause of morbidity and mortality worldwide (Giske et al., 2008). Antimicrobial agents are a major therapeutic tool in the treatment of such infections. However, antimicrobial resistance among Gram-negative bacteria, particularly among the Enterobacteriaceae and the non-fermenters, has become one of the most serious public health concerns worldwide (Giske et al., 2008;Livermore, 2012). The global dissemination of resistance has recently received much attention, especially following reports of the international spread of multi-resistant Enterobacteriaceae, particularly strains resistant to cephalosporins due to the production of CTX-M-type extended-spectrum b-lactamases (ESBLs) and strains producing carbapenemases such as KPC and NDM (Nordmann et al., 2011;Johnson & Woodford, 2013). The spread of resistance determinants is facilitated by a number of factors, including presence on genetic mobile elements, antibiotic misuse, poor infection control practices, and increased international travel. In this context Saudi Arabia is particularly relevant as it is annually a host for more than 4 million Muslim pilgrims from over 180 countries worldwide in the Hajj and Umra seasons. In addition, up to 6 million of the Kingdom's population are expatriates, mainly from south and east Asia, where antimicrobial resistance is rife, including to carbapenems (Yong et al., 2009). These factors could potentially make Saudi Arabia a hot spot for the collection of multidrug-resistant strains and the spread of antibiotic resistance around the world.We previously reported on the antimicrobial resistance among the key Gram-negative bacteria in Saudi Arabia and found increased prevalence of b-lactam-resistant strains, including ESBL-producers, and carbapenem resistance (Y...

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“…The studies have indicated that carbapenems resistance among Gram negative bacteria has become a global issue [13]. Recent studies showed that Saudi Arabia is considered among the countries that reported high rates of antimicrobial resistance [14] [15]. Thus, this study aimed to detect the prevalence of carbapenem resistance among Gram negative bacteria at the Al-Noor Specialist Hospital in the western part of Saudi Arabia, and monitoring to carbapenem resistance among these types of bacteria in order to devise strategies to counter threats from these extremely dangerous bacteria.…”

Section: Introductionmentioning

confidence: 99%

Trends in the Annual Incidence of Carbapenem Resistant among Gram Negative Bacilli in a Large Teaching Hospital in Makah City, Saudi Arabia

Faidah¹,

Momenah²,

El-Said³

et al. 2017

JTR

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Objective: To detect the prevalence of carbapenem resistance among Gram negative bacilli at the Al-Noor Specialist Hospital in the western part of Saudi Arabia. Materials and Methods: This study was conducted in the Microbiology department, Al-Noor Specialist Hospital, Makah city, Saudi Arabia. The clinical samples were collected from admitted patients in the wards, Intensive Care Units (ICUs), urology unit and surgery unit, these samples included blood, urine, sputum, pus and wound. The identification and antibiotic susceptibility testing of all bacterial isolates were performed via the Vitek 2 Compact System. Results: Out of 4803 Gram negative bacterial bacilli were isolated, the prevalence rate of carbapenem resistance among these isolates was 2797/4803 (58.23%), and sensitivity rate was 2006/4803 (41.77%) of the total isolates. The rate of resistance to carbapenem was among Acinetobacter baumannii 1710 (99.13%), followed by Pseudomonas aeruginosa 575 (62.4%), Klebsiella pneumoniae 459 (38%) and Escherichia coli 56 (5.59%). The trend of carbapenem resistance among Gram negative bacterial isolates from 2013-2015 was 53.99%, 59.88% and 61.43% respectively. Conclusion: A. baumannii recorded, the highest rate of carbapenem resistance through three year, 98.19%, 99.48% and 99.81% respectively and the lowest rate of resistance recorded with E. coli, 4.63%, 5.79% and 6.31% respectively.

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High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia

Cited by 37 publications

References 20 publications

The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt

The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt

The molecular basis of β-lactamase production in Gram-negative bacteria from Saudi Arabia

Trends in the Annual Incidence of Carbapenem Resistant among Gram Negative Bacilli in a Large Teaching Hospital in Makah City, Saudi Arabia

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