2013
DOI: 10.1155/2013/695918
|View full text |Cite
|
Sign up to set email alerts
|

High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the CanineMDR1/ABCB1Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

Abstract: A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
16
1

Year Published

2015
2015
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 11 publications
(17 citation statements)
references
References 15 publications
0
16
1
Order By: Relevance
“…Therefore, when P-gp substrates are administered to dogs that are potential carriers of this defect, animals should be carefully monitored for potential adverse effects, even if animals are heterozygous for the mutation. Importantly, we now recognize that there are genetic mutations other than the ABCB1-1D mutation that an lead to defective P-gp activity (Mizukami et al, 2013). It is incorrect to assume that the PK consequences of such defects will be uniform across all drugs.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, when P-gp substrates are administered to dogs that are potential carriers of this defect, animals should be carefully monitored for potential adverse effects, even if animals are heterozygous for the mutation. Importantly, we now recognize that there are genetic mutations other than the ABCB1-1D mutation that an lead to defective P-gp activity (Mizukami et al, 2013). It is incorrect to assume that the PK consequences of such defects will be uniform across all drugs.…”
Section: Discussionmentioning
confidence: 99%
“…al. 2010;Mizukami et al 2012;Mizukami et al 2013;Monobe et al 2015), yet the most important mutation remains the one which leads to a loss of four base pairs in 227-230 nucleotide, known as MDR1 (c.227-230del) or ABCB1-1螖 (Mizukami et al 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Several recent pharmacogenetic findings have been shown to be clinically relevant for patients of veterinary clinics, and the dog population is one of the most suitable models for examination of population genetics [ 15 22 ]. Clinically, Collies and other related dog breeds have been observed to be more susceptible to the effects of ivermectin on the central nervous system (CNS).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, very small doses (1/100-1/200 standard) cause acute and severe reactions in some, but not all Collie breeds. Collies also exhibit adverse reactions with higher concentrations of ivermectin in the brain [ 2 16 22 23 24 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation