We describe the design of a new polarization sensitive receiver, spt-3g, for the 10-meter South Pole Telescope (spt). The spt-3g receiver will deliver a factor of ∼20 improvement in mapping speed over the current receiver, spt-pol. The sensitivity of the spt-3g receiver will enable the advance from statistical detection of B-mode polarization anisotropy power to high signal-to-noise measurements of the individual modes, i.e., maps. This will lead to precise (∼0.06 eV) constraints on the sum of neutrino masses with the potential to directly address the neutrino mass hierarchy. It will allow a separation of the lensing and inflationary B-mode power spectra, improving constraints on the amplitude and shape of the primordial signal, either through spt-3g data alone or in combination with bicep2/keck, which is observing the same area of sky. The measurement of small-scale temperature anisotropy will provide new constraints on the epoch of reionization. Additional science from the spt-3g survey will be significantly enhanced by the synergy with the ongoing optical Dark Energy Survey (des), including: a 1% constraint on the bias of optical tracers of large-scale structure, a measurement of the differential Doppler signal from pairs of galaxy clusters that will test General Relativity on ∼200 Mpc scales, and improved cosmological constraints from the abundance of clusters of galaxies.

Motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down the precentral gyrus from foot to face representations1,2, despite evidence for concentric functional zones3 and maps of complex actions4. Here, using precision functional magnetic resonance imaging (fMRI) methods, we find that the classic homunculus is interrupted by regions with distinct connectivity, structure and function, alternating with effector-specific (foot, hand and mouth) areas. These inter-effector regions exhibit decreased cortical thickness and strong functional connectivity to each other, as well as to the cingulo-opercular network (CON), critical for action5 and physiological control6, arousal7, errors8 and pain9. This interdigitation of action control-linked and motor effector regions was verified in the three largest fMRI datasets. Macaque and pediatric (newborn, infant and child) precision fMRI suggested cross-species homologues and developmental precursors of the inter-effector system. A battery of motor and action fMRI tasks documented concentric effector somatotopies, separated by the CON-linked inter-effector regions. The inter-effectors lacked movement specificity and co-activated during action planning (coordination of hands and feet) and axial body movement (such as of the abdomen or eyebrows). These results, together with previous studies demonstrating stimulation-evoked complex actions4 and connectivity to internal organs10 such as the adrenal medulla, suggest that M1 is punctuated by a system for whole-body action planning, the somato-cognitive action network (SCAN). In M1, two parallel systems intertwine, forming an integrate–isolate pattern: effector-specific regions (foot, hand and mouth) for isolating fine motor control and the SCAN for integrating goals, physiology and body movement.

We constrain anisotropic cosmic birefringence using four-point correlations of even-parity E-mode and odd-parity B-mode polarization in the cosmic microwave background measurements made by the Polarbear experiment in its first season of observations. We find that the anisotropic cosmic 2 birefringence signal from any parity violating processes is consistent with zero. The Faraday rotation from anisotropic cosmic birefringence can be compared with the equivalent quantity generated by primordial magnetic fields if they existed. The Polarbear non-detection translates into a 95% confidence level (C.L.) upper limit of 93 nano-Gauss (nG) on the amplitude of an equivalent primordial magnetic field inclusive of systematic uncertainties. This four-point correlation constraint on Faraday rotation is about 15 times tighter than the upper limit of 1380 nG inferred from constraining the contribution of Faraday rotation to two-point correlations of B-modes measured by Planck in 2015. Metric perturbations sourced by primordial magnetic fields would also contribute to the B-mode power spectrum. Using the Polarbear measurements of the B-mode power spectrum (two-point correlation), we set a 95% C.L. upper limit of 3.9 nG on primordial magnetic fields assuming a flat prior on the field amplitude. This limit is comparable to what was found in the Planck 2015 two-point correlation analysis with both temperature and polarization. We perform a set of systematic error tests and find no evidence for contamination. This work marks the first time that anisotropic cosmic birefringence or primordial magnetic fields have been constrained from the ground at sub-degree scales.

We report a measurement of the B-mode polarization power spectrum in the cosmic microwave background (CMB) using the Polarbear experiment in Chile. The faint B-mode polarization signature carries information about the universe's entire history of gravitational structure formation, and the cosmic inflation that may have occurred in the very early universe. Our measurement covers the angular multipole range 500 < < 2100 and is based on observations of an effective sky area of 25 deg 2 with 3. 5 resolution at 150 GHz. On these angular scales, gravitational lensing of the CMB by intervening structure in the universe is expected to be the dominant source of B-mode polarization. Including both systematic and statistical uncertainties, the hypothesis of no B-mode polarization power from gravitational lensing is rejected at 97.2% confidence. The band powers are consistent with the standard cosmological model. Fitting a single lensing amplitude parameter A BB to the measured band powers, A BB = 1.12 ± 0.61(stat) +0.04 −0.12 (sys) ± 0.07(multi), where A BB = 1 is the fiducial wmap-9 ΛCDM value. In this expression, "stat" refers to the statistical uncertainty, "sys" to the systematic uncertainty associated with possible biases from the instrument and astrophysical foregrounds, and "multi" to the calibration uncertainties that have a multiplicative effect on the measured amplitude A BB .

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BackgroundAdaptive Radiotherapy aims to identify anatomical deviations during a radiotherapy course and modify the treatment plan to maintain treatment objectives. This requires regions of interest (ROIs) to be defined using the most recent imaging data. This study investigates the clinical utility of using deformable image registration (DIR) to automatically propagate ROIs.MethodsTarget (GTV) and organ-at-risk (OAR) ROIs were non-rigidly propagated from a planning CT scan to a per-treatment CT scan for 22 patients. Propagated ROIs were quantitatively compared with expert physician-drawn ROIs on the per-treatment scan using Dice scores and mean slicewise Hausdorff distances, and center of mass distances for GTVs. The propagated ROIs were qualitatively examined by experts and scored based on their clinical utility.ResultsGood agreement between the DIR-propagated ROIs and expert-drawn ROIs was observed based on the metrics used. 94% of all ROIs generated using DIR were scored as being clinically useful, requiring minimal or no edits. However, 27% (12/44) of the GTVs required major edits.ConclusionDIR was successfully used on 22 patients to propagate target and OAR structures for ART with good anatomical agreement for OARs. It is recommended that propagated target structures be thoroughly reviewed by the treating physician.

We present the design and experimental evaluation of a superconducting quantum interference device (SQUID) multiplexer for an array of low-temperature sensors. Each sensor is inductively coupled to a superconducting summing loop which, in turn, is inductively coupled to the readout SQUID. The flux-locked loop of the SQUID is used to null the current in the summing loop and thus cancel crosstalk. The sensors are biased with an alternating current, each with a separate frequency, and the individual sensor signals are separated by lock-in detection at the SQUID output. We have fabricated a prototype 8 channel multiplexer and discuss the application to a larger array.