High flaxseed (linseed) diet restores endothelial function in the mesenteric arterial bed of spontaneously hypertensive rats

Talom, Rabelais Tatchum; Judd, Shirley; Mcintosh, David D.; McNeill, J. Robert

doi:10.1016/s0024-3205(99)00075-2

Cited by 18 publications

(15 citation statements)

References 20 publications

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“…A flaxseed diet has also been shown to act as vasorelaxant and restore the endothelial function in SHR 26 . Hypertension may also increase several biochemical parameters associated with liver and kidney functions including AST, ALT, bilirubin, BUN, UA, creatinine and renin 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Bishri

2013

J. Oleo Sci.

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Section: Discussionmentioning

confidence: 99%

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Bishri

2013

J. Oleo Sci.

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“…Rats were exsanguinated by aortic puncture under isoflurane anesthesia. The superior mesenteric artery was cannulated and the gut removed as described previously (Talom et al 1999). The isolated MVB was perfused through the cannula at a constant flow rate of 5 mL/min and superfused at 0.2 mL/min using 2 separate pumps with modified Krebs-Henseleit buffer (in mmol/L: NaCl, 118; KCl, 4.7; MgCl 2 .6H 2 O, 1.2; NaH 2 PO 4 , 1.0; CaCl 2 .2H 2 O, 2.6; NaHCO 3 , 25; glucose, 11.1 at 37°C; pH 7.35-7.45), oxygenated with a 95% oxygen -5% carbon dioxide gas mixture.…”

Section: In Vitro Vascular Study In the Isolated Mvbmentioning

confidence: 99%

Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations

Tatchum-Talom¹,

Eyster²,

Martin³

2005

Can. J. Physiol. Pharmacol.

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Sex differences in the degree of high blood pressure have been described in several forms of experimental animal models of hypertension. However, the influence of sex on angiotensin II-induced hypertension has not been studied. In the present study, we investigated and compared the effects of chronic angiotensin II treatment on blood pressure and vascular function in male and female rats. Chronic treatment with angiotensin II (0.7 mg/kg daily for 10 d) significantly raised arterial blood pressure in male but not female Sprague-Dawley rats; it upregulated the NAD(P)H oxidase gp67 phox subunit in the aorta of male but not female rats; and it exaggerated the vasoconstrictor responses to norepinephrine and serotonin in the mesenteric vascular bed (MVB) of male but not female rats. Vasodilator responses to acetylcholine (ACh) but not papaverine (PPV) or isoprenaline (ISO) were reduced in the MVB of angiotensin II-treated male but not female rats. ACh, but not PPV or ISO dilatory responses were potentiated in the MVB of angiotensin II-treated female rats. The present findings demonstrate that exogenous angiotensin II upregulates aortic NAD(P)H oxidase gp67 phox subunit, and induces hypertension and mesenteric vascular dysfunction only in male rats.

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“…A previous report showed that feeding with a flaxseed-supplemented diet for 6, 8 or 16 weeks does not modify norepinephrine-induced vasoconstriction or the relaxation response induced through acetylcholine or sodium nitroprusside [7]. However, other reports have shown that a high-flaxseed diet enhances endothelial vasorelaxant function without reducing blood pressure in hypertensive rats [8]. Flaxseed is a rich source of plant lignans.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the cardiovascular effects of flaxseed could be attributed not only to PUFA, but also to the dietary fibers and phytoestrogen lignans presents in these grains. Previous reports concerning the vascular effect of flaxseed [7,8] have not provided evidence on whether the cardiovascular effects of flaxseed could be attributed to the PUFA present in the oil or the lignans and fibers present in the seeds.…”

Section: Introductionmentioning

confidence: 99%

Flaxseed oil increases aortic reactivity to phenylephrine through reactive oxygen species and the cyclooxygenase-2 pathway in rats

et al. 2014

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BackgroundFlaxseed oil has the highest concentration of omega-3 α-linolenic acid, which has been associated with cardiovascular benefit. However, the mechanism underlying the vascular effects induced through flaxseed oil is not well known. Thus, in the present study, we investigated the effects of flaxseed oil on vascular function in isolated rat aortic rings.MethodsWistar rats were treated daily with flaxseed oil or a control (mineral oil) intramuscular (i.m.) for fifteen days. Isolated aortic segments were used to evaluate cyclooxygenase-2 (COX-2) protein expression, superoxide anion levels and vascular reactivity experiments.ResultsFlaxseed oil treatment increased the vasoconstrictor response of aortic rings to phenylephrine. Endothelium removal increased the response to phenylephrine in aortic segments isolated from both groups, but the effect was smaller in the treated group. L-NAME incubation similarly increased the phenylephrine response in segments from both groups. The TXA2 synthase inhibitor furegrelate, the selective COX-2 inhibitor NS 398, the TP receptor antagonist SQ 29.548, the reactive oxygen species (ROS) scavenger apocynin, the superoxide anion scavengers tiron and the phospholipase A2 inhibitor dexamethasone partially reversed the flaxseed oil-induced increase in reactivity to phenylephrine.ConclusionsThese findings suggest that flaxseed oil treatment increased vascular reactivity to phenylephrine through an increase in ROS production and COX-2-derived TXA2 production. The results obtained in the present study provide new insight into the effects of flaxseed oil treatment (i.m.) on vascular function.

show abstract

High flaxseed (linseed) diet restores endothelial function in the mesenteric arterial bed of spontaneously hypertensive rats

Cited by 18 publications

References 20 publications

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations

Flaxseed oil increases aortic reactivity to phenylephrine through reactive oxygen species and the cyclooxygenase-2 pathway in rats

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