High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Labbé, David P.; Zadra, Giorgia; Yang, Meng; Reyes, Jaime M.; Lin, Charles Y.; Cacciatore, Stefano; Ebot, Ericka M.; Creech, Amanda L.; Giunchi, Francesca; Fiorentino, Michelangelo; Elfandy, Habiba; Syamala, Sudeepa; Karoly, Edward D.; Alshalalfa, Mohammed; Erho, Nicholas; Ross, Ashley E.; Schaeffer, Edward M.; Gibb, Ewan A.; Takhar, Mandeep; Den, Robert B.; Lehrer, Jonathan; Karnes, R. Jeffrey; Freedland, Stephen J.; Davicioni, Elai; Spratt, Daniel E.; Ellis, Leigh; Jaffe, Jacob D.; D’Amico, Anthony V.; Kantoff, Philip W.; Bradner, James E.; Mucci, Lorelei A.; Chavarro, Jorge E.; Loda, Massimo; Brown, Myles

doi:10.1038/s41467-019-12298-z

Cited by 129 publications

(146 citation statements)

References 81 publications

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“…Epidemiological studies show that although high intake of saturated fatty acids (abundant in meat and butter) decrease the survival rate of PCa patients, unsaturated fatty acids (abundant in fish and vegetable oils) reportedly reduce the risk of PCa [35,36]. An animal study showed that mimicking MYC overexpression induces PCa progression in PCa-model mice fed a diet high in saturated fatty acids [37]. However, suppression of PCa cell proliferation by intake of unsaturated fatty acids, such as eicosapentaenoic acids, docosahexaenoic acids, and α-linolenic acids, was demonstrated in an animal study and several in vitro experiments using human PCa cell lines [38][39][40][41].…”

Section: Fatmentioning

confidence: 99%

Influence of Diet and Nutrition on Prostate Cancer

Matsushita

Fujita

Nonomura

2020

IJMS

120

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The incidence of prostate cancer (PCa) displays widespread regional differences, probably owing to differences in dietary habits. Nutrients, including fat, protein, carbohydrates, vitamins (vitamin A, D, and E), and polyphenols, potentially affect PCa pathogenesis and progression, as previously reported using animal models; however, clinical studies have reported controversial results for almost all nutrients. The effects of these nutrients may be manifested through various mechanisms including inflammation, antioxidant effects, and the action of sex hormones. Dietary patterns including the Western and Prudent patterns also influence the risk of PCa. Recent studies reported that the gut microbiota contribute to tumorigenesis in some organs. Diet composition and lifestyle have a direct and profound effect on the gut bacteria. Human studies reported an increase in the abundance of specific gut bacteria in PCa patients. Although there are few studies concerning their relationship, diet and nutrition could influence PCa, and this could be mediated by gut microbiota. An intervention of dietary patterns could contribute to the prevention of PCa. An intervention targeting dietary patterns may thus help prevent PCa.

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Section: Fatmentioning

confidence: 99%

Influence of Diet and Nutrition on Prostate Cancer

Matsushita

Fujita

Nonomura

2020

IJMS

120

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“…Indeed, recent studies using human prostate regeneration models have shown a carcinogenic effect of steroids [32]. Thus, a diet rich in fat, compatible with a diet high in processed foods, could perhaps contribute to the pathogenesis of prostate cancer [33].…”

Section: Potential Mechanismsmentioning

confidence: 99%

Extent of Food Processing and Risk of Prostate Cancer: The PROtEuS Study in Montreal, Canada

2020

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We studied the association between food intake, based on the extent of processing, and prostate cancer risk in a population-based case-control study conducted in Montreal, Canada in 2005–2012. Incident prostate cancer cases (n = 1919) aged ≤75 years were histologically confirmed. Population controls (n = 1991) were randomly selected from the electoral list and frequency-matched to cases by age (±5 years). A 63-item food frequency questionnaire focusing on the two years prior to diagnosis/interview was administered by interviewers. The NOVA classification was used to categorize foods based on processing level. Unconditional logistic regression estimated the association between food intake and prostate cancer risk, adjusting for age, education, ethnicity, family history, and timing of last prostate cancer screening. Consumption of unprocessed or minimally processed foods showed a slight, inverse association (Odd ratio [OR] 0.86, 95% confidence interval [CI] 0.70–1.07; highest vs. lowest quartile) with prostate cancer. An increased risk was observed with higher intake of processed foods (OR 1.29, 95%CI 1.05–1.59; highest vs. lowest quartile), but not with consumption of ultra-processed food and drinks. The associations with unprocessed/minimally processed foods and processed foods were slightly more pronounced for high-grade cancers (ORs 0.80 and 1.33, respectively). Findings suggest that food processing may influence prostate cancer risk.

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“…It is important to highlight that a recent projection points to Brazil as the next putative global pandemic epicenter for COVID-19, 72 and in September of 2020, Brazil became the country with the second most confirmed cases, equal to 4 123 000. 73 Fortunately, Brazil has the biggest NMR facility in Latin America, the National Center of Nuclear Magnetic Resonance, which houses several field magnets, including 400, 500, 600, 700, and 800 MHz magnets as well as the recently installed 900 MHz magnet (the strongest NMR field magnet in Latin America).…”

Section: Perspective For Brazilmentioning

confidence: 99%

Saliva NMR-Based Metabolomics in the War Against COVID-19

et al. 2020

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COVID-19 is an emergent, worldwide public health concern. Joint efforts have been made by scientific communities of various fields to better understand the mechanisms of action of SARS-CoV-2. The need to understand the pathophysiological fingerprint and pathways of this disease make metabolomics-related approaches an indispensable tool for properly answering concerns relating to disease course. Determination of the metabolomic profile may help to explain the heterogeneous spectra of COVID-19 clinical phenotypes and be useful in monitoring disease progression as well as therapeutic treatments. In this sense, saliva has proven to be a strategic biofluid, owing not only to its appeal as a noninvasive sampling method but also due to the capacity of the virus to invade epithelial cells of the oral mucosa and salivary gland ducts via ACE2 receptors. Accordingly, important changes in metabolism have been described relating to COVID-19, indicating that metabolomics may open new avenues for understanding the pathophysiology of this disease, especially via longitudinal study designs. Thus, we discuss the importance of comprehending the SARS-CoV-2 salivary metabolomic fingerprint and also highlight the situation of Brazil on the frontlines of the war against COVID-19.

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High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Cited by 129 publications

References 81 publications

Influence of Diet and Nutrition on Prostate Cancer

Influence of Diet and Nutrition on Prostate Cancer

Extent of Food Processing and Risk of Prostate Cancer: The PROtEuS Study in Montreal, Canada

Saliva NMR-Based Metabolomics in the War Against COVID-19

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