High fat diet and high polyphenols beverages effects in enzymatic and non-enzymatic antioxidant activity

Ribeiro, Vânia; Bedê, Teresa Palmisciano; Rocha, Gabrielle de Souza; Barroso, Sérgio; Valença, Samuel dos Santos; Azeredo, Vilma Blondet de

doi:10.20960/nh.1219

Cited by 4 publications

(4 citation statements)

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“…This specific response depends not only on ROS levels but also on the tissue (Ribeiro et al. 2017 ). GSH is an endogenous defense against the oxidative stress that can act with GST and GPx enzymes or in the process of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet

Ortega-Pérez

Piñón-Simental

Magaña-Rodríguez

et al. 2022

Pharmaceutical Biology

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Context Callistemon citrinus Skeels (Myrtaceae) exhibits many biological activities. Objective This study analyzes for the first time, the toxicity, obesogenic, and antioxidant effects of C. citrinus in rats fed with a high fat-fructose diet (HFFD). Materials and methods Four studies using male Wistar rats were conducted: (a) 7 groups ( n = 3): control (corn oil) and ethanol extract of C. citrinus leaf (single oral dose at 100–4000 mg/kg) for acute toxicity; (b) 2 groups ( n = 8): control (corn oil) and C. citrinus (1000 mg/kg/day) for 28 days for subacute toxicity; (c) 3 groups ( n = 4) with single oral dose of lipid emulsion: control (lipid emulsion), C. citrinus and orlistat (250 and 50 mg/kg, respectively) for lipid absorption; (d) 4 groups ( n = 6): control (normal diet) and 3 groups fed with HFFD: HFFD only, C. citrinus and simvastatin (oral dose 250 and 3 mg/kg, respectively) for 13 weeks. Antioxidant enzymes and biomarkers were evaluated and inhibition of pancreatic lipase was determined in vitro . Results Toxicological studies of C. citrinus showed no differences in biochemical parameters and lethal dose (LD 50 ) was higher than 4000 mg/kg. C. citrinus inhibited pancreatic lipase activity, with IC 50 of 392.00 µg/mL, and decreased lipid absorption by 70%. Additionally, it reduced the body weight 22%, restored the activities of antioxidant enzymes, and reduced the biomarkers of oxidative stress. Conclusions Callistemon citrinus showed an effect against oxidative stress by reducing biomarkers and induced antioxidant system, without toxic effects.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet

Ortega-Pérez

Piñón-Simental

Magaña-Rodríguez

et al. 2022

Pharmaceutical Biology

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“…44 High-molecular-weight phenolics derived from red grapes could effectively reduce the harmful impacts of a high-fat diet and play an important role in scavenging free radicals. 45 Resveratrol administration effectively lowered the level of fasting blood glucose and raised high-density lipoprotein cholesterol (HDL-C) levels. 46 Consuming a diet of plant extracts rich in phenolics appears to have similar effects.…”

Section: Classification Of Phenolicsmentioning

confidence: 99%

“…Additionally, they significantly reduced levels of lipid peroxidation and carbonylated protein, and lowered oxidative stress levels in both plasma and tissues 44 . High‐molecular‐weight phenolics derived from red grapes could effectively reduce the harmful impacts of a high‐fat diet and play an important role in scavenging free radicals 45 . Resveratrol administration effectively lowered the level of fasting blood glucose and raised high‐density lipoprotein cholesterol (HDL‐C) levels 46 .…”

Section: Plant Phenolicsmentioning

confidence: 99%

Research progress on the regulation of oxidative stress by phenolics: the role of gut microbiota and Nrf2 signaling pathway

Liu,

Wang,

Podio

et al. 2023

J Sci Food Agric

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In recent years, the increase in high‐calorie diets and sedentary lifestyles has made obesity a global public health problem. An unbalanced diet promotes the production of proinflammatory cytokines and causes redox imbalance in the body. Phenolics have potent antioxidant activity and cytoprotective ability. They can scavenge free radicals and reactive oxygen species, and enhance the activity of antioxidant enzymes, thus combating the body's oxidative stress. They can also improve the body's inflammatory response, enhance the enzyme activity of lipid metabolism, and reduce the contents of cholesterol and triglyceride. Most phenolics are biotransformed and absorbed into the blood after the action by gut microbiota, then these metabolites undergo phase I and II metabolism and regulate oxidative stress by scavenging free radicals and increasing expression of antioxidant enzymes. Phenolics induce the expression of genes encoding anti‐oxidant enzymes and phase II detoxification enzymes by stimulating Nrf2 to enter the nucleus and bind to the ARE after uncoupling from Keap1, thereby promoting the production of antioxidant enzymes and phase II detoxification enzymes. The absorption rate of phenolics in the small intestine is extremely low. Most phenolics reach the colon, where they interact with the microbiota and undergo a series of metabolism. Their metabolites will reach the liver via the portal vein and undergo conjugation reactions. Afterward, the metabolites reach the whole body to exert biological activity by traveling with the systemic circulation. Phenolics can promote the growth of probiotics, reduce the ratio of Firmicutes/Bacteroidetes (F/B), and improve intestinal microecological imbalance. This paper reviewed the nutritional value, bioactivity, and antioxidant mechanism of phenolics in the body, aiming to provide a scientific basis for the development and utilization of natural antioxidants and provide a reference for elucidating the mechanism of action of phenolics for regulating oxidative stress in the body.This article is protected by copyright. All rights reserved.

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“…In vitro studies suggest that polyphenols have the ability to inhibit lipoxygenases and cyclooxygenases prevents the release of arachidonic metabolites, an alternative source of non-mitochondrial ROS [38]. They are also able to increase the activity of potent antioxidant enzymes such as SOD, CAT, and GPX [39]. Antioxidant activity is correlated positively with the number of hydroxyl groups bound to the aromatic ring [40].…”

Section: Reactive Oxygen Species (Ros) and Polyphenols As Two Oppomentioning

confidence: 99%

Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties

Zielińska‐Bliźniewska

Sitarek

Merecz-Sadowska

et al. 2019

IJMS

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Obesity is a complex disease of great public health significance worldwide: It entails several complications including diabetes mellitus type 2, cardiovascular dysfunction and hypertension, and its prevalence is increasing around the world. The pathogenesis of obesity is closely related to reactive oxygen species. The role of reactive oxygen species as regulatory factors in mitochondrial activity in obese subjects, molecules taking part in inflammation processes linked to excessive size and number of adipocytes, and as agents governing the energy balance in hypothalamus neurons has been examined. Phytotherapy is the traditional form of treating health problems using plant-derived medications. Some plant extracts are known to act as anti-obesity agents and have been screened in in vitro models based on the inhibition of lipid accumulation in 3T3-L1 cells and activity of pancreatic lipase methods and in in vivo high-fat diet-induced obesity rat/mouse models and human models. Plant products may be a good natural alternative for weight management and a source of numerous biologically-active chemicals, including antioxidant polyphenols that can counteract the oxidative stress associated with obesity. This review presents polyphenols as natural complementary therapy, and a good nutritional strategy, for treating obesity without serious side effects.

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High fat diet and high polyphenols beverages effects in enzymatic and non-enzymatic antioxidant activity

Abstract: Grape juice showed to be the most effective in minimizing the deleterious effects of a high fat diet. Resveratrol did not present any benefit and red wine possibly shows a harmful effect due to ethanol content.

Cited by 4 publications

References 0 publications

Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet

Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet

Research progress on the regulation of oxidative stress by phenolics: the role of gut microbiota and Nrf2 signaling pathway

Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties

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