2003
DOI: 10.1097/01.tp.0000069829.71088.88
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Abstract: TIAF-1 mRNA and protein are predominantly up-regulated in kidney and liver allografts with chronic rejection. This does not seem to be related to the cyclosporine A therapy. Expression of TIAF-1 in the lymphocytes during chronic allograft rejection may be related to the predominance of a Th2 response in this condition. The expression in the transplanted tissue may protect these cells from apoptosis.

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Cited by 18 publications
(10 citation statements)
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“…Most intriguingly, the level of TIAF1 is significantly increased in patients with chronic kidney and liver allograft rejection and in their activated TH2 helper T lymphocytes (Van Der Leij et al, 2003). Although the underlying mechanisms are poorly understood, we believe that TIAF1 may regulate the TH2 response, by either regulating cytokine production or TH2 cell proliferation, which leads to chronic allograft rejection.…”
Section: Discussionmentioning
confidence: 95%
“…Most intriguingly, the level of TIAF1 is significantly increased in patients with chronic kidney and liver allograft rejection and in their activated TH2 helper T lymphocytes (Van Der Leij et al, 2003). Although the underlying mechanisms are poorly understood, we believe that TIAF1 may regulate the TH2 response, by either regulating cytokine production or TH2 cell proliferation, which leads to chronic allograft rejection.…”
Section: Discussionmentioning
confidence: 95%
“…Both TP53INP1 and TIAF1 genes were found to be overexpressed in the naturally occurring T Reg cells in our study. Apart from this, TIAF1 is known to be upregulated in T h 2 compared with T h 1 lymphocytes, and a functional role as an apoptosis protector has been discussed [31]. …”
Section: Resultsmentioning
confidence: 99%
“…TIAF1, a 12-kDa TIAF1, 6 participates in TGF- β signaling 7 and controls p53 activation. 8 TIAF1 is implicated in the activation of TH2 helper T lymphocytes in chronic organ rejection 9 and development of regulatory T cells, 10 as well as association with Hirschsprung's disease. 11 TIAF1 tends to aggregate, and the protein aggregates are found in the hippocampi of postmortem nondemented humans and AD patients.…”
mentioning
confidence: 99%