1999
DOI: 10.1177/030006059902700204
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High Expression of Multidrug Resistance-1 (MDR-1) and its Relationship with Multiple Prognostic Factors in Gastric Carcinomas in Patients in Turkey

Abstract: Drug resistance remains a major problem in the treatment of gastric cancer. In Turkey, gastric carcinoma is the second most common cancer and, because the rate of early diagnosis is low, chemotherapy plays an important role in the treatment of the disease. We aimed to investigate expression of the multidrug resistance-1 gene (MDR-1) and its relationship with multiple prognostic factors in gastric cancers. Between 1996 and 1998, a total of 55 patients (37 men and 19 women; median age 55 years) were studied. Sec… Show more

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Cited by 21 publications
(13 citation statements)
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“…4 Similarly, other researchers also reported that these transporters were found only in a part of gastric cancer specimens. [5][6][7][8] All these data suggested unknown molecules and mechanisms responsible for MDR in gastric cancer.…”
Section: Introductionmentioning
confidence: 89%
“…4 Similarly, other researchers also reported that these transporters were found only in a part of gastric cancer specimens. [5][6][7][8] All these data suggested unknown molecules and mechanisms responsible for MDR in gastric cancer.…”
Section: Introductionmentioning
confidence: 89%
“…ABCB1, also known as P-glycoprotein and MDR1, was the first ABC transporter to be identified and has been studied extensively. The overexpression of ABCB1 has been found in human gastric cancer cell lines and in clinical gastric cancer tissues[ 7 - 9 ]. The association between ABCB1 expression and the clinicopathological characteristics of patients with gastric cancer is not fully understood.…”
Section: Reduced Intracellular Concentration Of Drugsmentioning
confidence: 99%
“…However, it has been confirmed that not all gastric cancer cells or tissues express these transporters. Gurel et al [5] and Yeh et al [6] found, by immunohistochemical staining, that the positive rate for P-gp in gastric cancer tissues was 87% in Turkey and 13.3% in Taiwan district, respectively. According to Takebayashi et al [7], only 34.1% of gastric cancer tissues from 103 patients expressed MRP.…”
Section: Introductionmentioning
confidence: 98%